The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury
Traumatic brain injury (TBI) is a structural and physiological disruption of brain function caused by external forces. It is a major cause of death and disability for patients worldwide. TBI includes both primary and secondary impairments. Iron overload and ferroptosis highly involved in the pathoph...
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| Format: | Article |
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Frontiers Media S.A.
2020-09-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fncel.2020.590789/full |
| _version_ | 1818198937211764736 |
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| author | Sicheng Tang Pan Gao Hanmin Chen Xiangyue Zhou Yibo Ou Yue He |
| author_facet | Sicheng Tang Pan Gao Hanmin Chen Xiangyue Zhou Yibo Ou Yue He |
| author_sort | Sicheng Tang |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) is a structural and physiological disruption of brain function caused by external forces. It is a major cause of death and disability for patients worldwide. TBI includes both primary and secondary impairments. Iron overload and ferroptosis highly involved in the pathophysiological process of secondary brain injury. Ferroptosis is a form of regulatory cell death, as increased iron accumulation in the brain leads to lipid peroxidation, reactive oxygen species (ROS) production, mitochondrial dysfunction and neuroinflammatory responses, resulting in cellular and neuronal damage. For this reason, eliminating factors like iron deposition and inhibiting lipid peroxidation may be a promising therapy. Iron chelators can be used to eliminate excess iron and to alleviate some of the clinical manifestations of TBI. In this review we will focus on the mechanisms of iron and ferroptosis involving the manifestations of TBI, broaden our understanding of the use of iron chelators for TBI. Through this review, we were able to better find novel clinical therapeutic directions for further TBI study. |
| first_indexed | 2024-12-12T02:13:48Z |
| format | Article |
| id | doaj.art-f190e1ea30b3442c91d02f6f79e6f8ab |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-12T02:13:48Z |
| publishDate | 2020-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-f190e1ea30b3442c91d02f6f79e6f8ab2022-12-22T00:41:50ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022020-09-011410.3389/fncel.2020.590789590789The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain InjurySicheng Tang0Pan Gao1Hanmin Chen2Xiangyue Zhou3Yibo Ou4Yue He5Medical Clinic and Polyclinic IV, Ludwig-Maximilians-University Munich (LMU), Munich, GermanyDepartment of Translational Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Munich, GermanyDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaTraumatic brain injury (TBI) is a structural and physiological disruption of brain function caused by external forces. It is a major cause of death and disability for patients worldwide. TBI includes both primary and secondary impairments. Iron overload and ferroptosis highly involved in the pathophysiological process of secondary brain injury. Ferroptosis is a form of regulatory cell death, as increased iron accumulation in the brain leads to lipid peroxidation, reactive oxygen species (ROS) production, mitochondrial dysfunction and neuroinflammatory responses, resulting in cellular and neuronal damage. For this reason, eliminating factors like iron deposition and inhibiting lipid peroxidation may be a promising therapy. Iron chelators can be used to eliminate excess iron and to alleviate some of the clinical manifestations of TBI. In this review we will focus on the mechanisms of iron and ferroptosis involving the manifestations of TBI, broaden our understanding of the use of iron chelators for TBI. Through this review, we were able to better find novel clinical therapeutic directions for further TBI study.https://www.frontiersin.org/article/10.3389/fncel.2020.590789/fullironferroptosistraumatic brain injuryiron metabolic disorderiron chelatorreactive oxygen species |
| spellingShingle | Sicheng Tang Pan Gao Hanmin Chen Xiangyue Zhou Yibo Ou Yue He The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury Frontiers in Cellular Neuroscience iron ferroptosis traumatic brain injury iron metabolic disorder iron chelator reactive oxygen species |
| title | The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury |
| title_full | The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury |
| title_fullStr | The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury |
| title_full_unstemmed | The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury |
| title_short | The Role of Iron, Its Metabolism and Ferroptosis in Traumatic Brain Injury |
| title_sort | role of iron its metabolism and ferroptosis in traumatic brain injury |
| topic | iron ferroptosis traumatic brain injury iron metabolic disorder iron chelator reactive oxygen species |
| url | https://www.frontiersin.org/article/10.3389/fncel.2020.590789/full |
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