The Emerging Role of Epigenetics in Metabolism and Endocrinology
Each cell in a multicellular organism has its own phenotype despite sharing the same genome. Epigenetics is a somatic, heritable pattern of gene expression or cellular phenotype mediated by structural changes in chromatin that occur without altering the DNA sequence. Epigenetic modification is an im...
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MDPI AG
2023-02-01
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| author | Belay Zeleke Sibuh Sameer Quazi Hrithika Panday Ritika Parashar Niraj Kumar Jha Runjhun Mathur Saurabh Kumar Jha Pankaj Taneja Abhimanyu Kumar Jha |
| author_facet | Belay Zeleke Sibuh Sameer Quazi Hrithika Panday Ritika Parashar Niraj Kumar Jha Runjhun Mathur Saurabh Kumar Jha Pankaj Taneja Abhimanyu Kumar Jha |
| author_sort | Belay Zeleke Sibuh |
| collection | DOAJ |
| description | Each cell in a multicellular organism has its own phenotype despite sharing the same genome. Epigenetics is a somatic, heritable pattern of gene expression or cellular phenotype mediated by structural changes in chromatin that occur without altering the DNA sequence. Epigenetic modification is an important factor in determining the level and timing of gene expression in response to endogenous and exogenous stimuli. There is also growing evidence concerning the interaction between epigenetics and metabolism. Accordingly, several enzymes that consume vital metabolites as substrates or cofactors are used during the catalysis of epigenetic modification. Therefore, altered metabolism might lead to diseases and pathogenesis, including endocrine disorders and cancer. In addition, it has been demonstrated that epigenetic modification influences the endocrine system and immune response-related pathways. In this regard, epigenetic modification may impact the levels of hormones that are important in regulating growth, development, reproduction, energy balance, and metabolism. Altering the function of the endocrine system has negative health consequences. Furthermore, endocrine disruptors (EDC) have a significant impact on the endocrine system, causing the abnormal functioning of hormones and their receptors, resulting in various diseases and disorders. Overall, this review focuses on the impact of epigenetics on the endocrine system and its interaction with metabolism. |
| first_indexed | 2024-03-11T09:08:29Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T09:08:29Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-f191934b0b194d7d8020711b52f2fcf52023-11-16T19:13:50ZengMDPI AGBiology2079-77372023-02-0112225610.3390/biology12020256The Emerging Role of Epigenetics in Metabolism and EndocrinologyBelay Zeleke Sibuh0Sameer Quazi1Hrithika Panday2Ritika Parashar3Niraj Kumar Jha4Runjhun Mathur5Saurabh Kumar Jha6Pankaj Taneja7Abhimanyu Kumar Jha8Department of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, IndiaGenLab Biosolutions Private Limited, Bangalore 560043, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Knowledge Park III, Greater Noida 201310, IndiaEach cell in a multicellular organism has its own phenotype despite sharing the same genome. Epigenetics is a somatic, heritable pattern of gene expression or cellular phenotype mediated by structural changes in chromatin that occur without altering the DNA sequence. Epigenetic modification is an important factor in determining the level and timing of gene expression in response to endogenous and exogenous stimuli. There is also growing evidence concerning the interaction between epigenetics and metabolism. Accordingly, several enzymes that consume vital metabolites as substrates or cofactors are used during the catalysis of epigenetic modification. Therefore, altered metabolism might lead to diseases and pathogenesis, including endocrine disorders and cancer. In addition, it has been demonstrated that epigenetic modification influences the endocrine system and immune response-related pathways. In this regard, epigenetic modification may impact the levels of hormones that are important in regulating growth, development, reproduction, energy balance, and metabolism. Altering the function of the endocrine system has negative health consequences. Furthermore, endocrine disruptors (EDC) have a significant impact on the endocrine system, causing the abnormal functioning of hormones and their receptors, resulting in various diseases and disorders. Overall, this review focuses on the impact of epigenetics on the endocrine system and its interaction with metabolism.https://www.mdpi.com/2079-7737/12/2/256cancerDNA methylationendocrine disruptorsendocrine systemepigeneticshistone modification |
| spellingShingle | Belay Zeleke Sibuh Sameer Quazi Hrithika Panday Ritika Parashar Niraj Kumar Jha Runjhun Mathur Saurabh Kumar Jha Pankaj Taneja Abhimanyu Kumar Jha The Emerging Role of Epigenetics in Metabolism and Endocrinology Biology cancer DNA methylation endocrine disruptors endocrine system epigenetics histone modification |
| title | The Emerging Role of Epigenetics in Metabolism and Endocrinology |
| title_full | The Emerging Role of Epigenetics in Metabolism and Endocrinology |
| title_fullStr | The Emerging Role of Epigenetics in Metabolism and Endocrinology |
| title_full_unstemmed | The Emerging Role of Epigenetics in Metabolism and Endocrinology |
| title_short | The Emerging Role of Epigenetics in Metabolism and Endocrinology |
| title_sort | emerging role of epigenetics in metabolism and endocrinology |
| topic | cancer DNA methylation endocrine disruptors endocrine system epigenetics histone modification |
| url | https://www.mdpi.com/2079-7737/12/2/256 |
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