MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases
Neurodegenerative diseases are debilitating and currently incurable conditions causing severe cognitive and motor impairments, defined by the progressive deterioration of neuronal structure and function, eventually causing neuronal loss. Understand the molecular and cellular mechanisms underlying th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/17/5986 |
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| author | Mariano Catanesi Michele d’Angelo Maria Grazia Tupone Elisabetta Benedetti Antonio Giordano Vanessa Castelli Annamaria Cimini |
| author_facet | Mariano Catanesi Michele d’Angelo Maria Grazia Tupone Elisabetta Benedetti Antonio Giordano Vanessa Castelli Annamaria Cimini |
| author_sort | Mariano Catanesi |
| collection | DOAJ |
| description | Neurodegenerative diseases are debilitating and currently incurable conditions causing severe cognitive and motor impairments, defined by the progressive deterioration of neuronal structure and function, eventually causing neuronal loss. Understand the molecular and cellular mechanisms underlying these disorders are essential to develop therapeutic approaches. MicroRNAs (miRNAs) are short non-coding RNAs implicated in gene expression regulation at the post-transcriptional level. Moreover, miRNAs are crucial for different processes, including cell growth, signal transmission, apoptosis, cancer and aging-related neurodegenerative diseases. Altered miRNAs levels have been associated with the formation of reactive oxygen species (ROS) and mitochondrial dysfunction. Mitochondrial dysfunction and ROS formation occur in many neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases. The crosstalk existing among oxidative stress, mitochondrial dysfunction and miRNAs dysregulation plays a pivotal role in the onset and progression of neurodegenerative diseases. Based on this evidence, in this review, with a focus on miRNAs and their role in mitochondrial dysfunction in aging-related neurodegenerative diseases, with a focus on their potential as diagnostic biomarkers and therapeutic targets. |
| first_indexed | 2024-03-10T17:08:23Z |
| format | Article |
| id | doaj.art-f1924a53c1154f40815567c2a126368c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T17:08:23Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f1924a53c1154f40815567c2a126368c2023-11-20T10:44:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012117598610.3390/ijms21175986MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative DiseasesMariano Catanesi0Michele d’Angelo1Maria Grazia Tupone2Elisabetta Benedetti3Antonio Giordano4Vanessa Castelli5Annamaria Cimini6Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalySbarro Institute for Cancer Research and Molecular Medicine and Centre for Biotechnology, Temple University, Philadelphia, PA 19122, USADepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyNeurodegenerative diseases are debilitating and currently incurable conditions causing severe cognitive and motor impairments, defined by the progressive deterioration of neuronal structure and function, eventually causing neuronal loss. Understand the molecular and cellular mechanisms underlying these disorders are essential to develop therapeutic approaches. MicroRNAs (miRNAs) are short non-coding RNAs implicated in gene expression regulation at the post-transcriptional level. Moreover, miRNAs are crucial for different processes, including cell growth, signal transmission, apoptosis, cancer and aging-related neurodegenerative diseases. Altered miRNAs levels have been associated with the formation of reactive oxygen species (ROS) and mitochondrial dysfunction. Mitochondrial dysfunction and ROS formation occur in many neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s diseases. The crosstalk existing among oxidative stress, mitochondrial dysfunction and miRNAs dysregulation plays a pivotal role in the onset and progression of neurodegenerative diseases. Based on this evidence, in this review, with a focus on miRNAs and their role in mitochondrial dysfunction in aging-related neurodegenerative diseases, with a focus on their potential as diagnostic biomarkers and therapeutic targets.https://www.mdpi.com/1422-0067/21/17/5986miRNAsmitochondrial dysfunctionreactive oxygen speciesneurodegenerative diseaseaging |
| spellingShingle | Mariano Catanesi Michele d’Angelo Maria Grazia Tupone Elisabetta Benedetti Antonio Giordano Vanessa Castelli Annamaria Cimini MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases International Journal of Molecular Sciences miRNAs mitochondrial dysfunction reactive oxygen species neurodegenerative disease aging |
| title | MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases |
| title_full | MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases |
| title_fullStr | MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases |
| title_full_unstemmed | MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases |
| title_short | MicroRNAs Dysregulation and Mitochondrial Dysfunction in Neurodegenerative Diseases |
| title_sort | micrornas dysregulation and mitochondrial dysfunction in neurodegenerative diseases |
| topic | miRNAs mitochondrial dysfunction reactive oxygen species neurodegenerative disease aging |
| url | https://www.mdpi.com/1422-0067/21/17/5986 |
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