Clinical-Radiomics Nomogram Based on Contrast-Enhanced Ultrasound for Preoperative Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma
This study aimed to establish a new clinical-radiomics nomogram based on ultrasound (US) for cervical lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC). We collected 211 patients with PTC between June 2018 and April 2020, then we randomly divided these patients into the training set (...
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MDPI AG
2023-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/5/1613 |
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| author | Liqing Jiang Zijian Zhang Shiyan Guo Yongfeng Zhao Ping Zhou |
| author_facet | Liqing Jiang Zijian Zhang Shiyan Guo Yongfeng Zhao Ping Zhou |
| author_sort | Liqing Jiang |
| collection | DOAJ |
| description | This study aimed to establish a new clinical-radiomics nomogram based on ultrasound (US) for cervical lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC). We collected 211 patients with PTC between June 2018 and April 2020, then we randomly divided these patients into the training set (<i>n</i> = 148) and the validation set (<i>n</i> = 63). 837 radiomics features were extracted from B-mode ultrasound (BMUS) images and contrast-enhanced ultrasound (CEUS) images. The maximum relevance minimum redundancy (mRMR) algorithm, least absolute shrinkage and selection operator (LASSO) algorithm, and backward stepwise logistic regression (LR) were applied to select key features and establish a radiomics score (Radscore), including BMUS Radscore and CEUS Radscore. The clinical model and clinical-radiomics model were established using the univariate analysis and multivariate backward stepwise LR. The clinical-radiomics model was finally presented as a clinical-radiomics nomogram, the performance of which was evaluated by the receiver operating characteristic curves, Hosmer–Lemeshow test, calibration curves, and decision curve analysis (DCA). The results show that the clinical-radiomics nomogram was constructed by four predictors, including gender, age, US-reported LNM, and CEUS Radscore. The clinical-radiomics nomogram performed well in both the training set (AUC = 0.820) and the validation set (AUC = 0.814). The Hosmer–Lemeshow test and the calibration curves demonstrated good calibration. The DCA showed that the clinical-radiomics nomogram had satisfactory clinical utility. The clinical-radiomics nomogram constructed by CEUS Radscore and key clinical features can be used as an effective tool for individualized prediction of cervical LNM in PTC. |
| first_indexed | 2024-03-11T07:29:18Z |
| format | Article |
| id | doaj.art-f1927805bc864dd2a9cecd1e35313c3d |
| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T07:29:18Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f1927805bc864dd2a9cecd1e35313c3d2023-11-17T07:26:27ZengMDPI AGCancers2072-66942023-03-01155161310.3390/cancers15051613Clinical-Radiomics Nomogram Based on Contrast-Enhanced Ultrasound for Preoperative Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid CarcinomaLiqing Jiang0Zijian Zhang1Shiyan Guo2Yongfeng Zhao3Ping Zhou4Department of Ultrasound, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaXiangya Lung Cancer Center, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Ultrasound, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Ultrasound, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaDepartment of Ultrasound, The Third Xiangya Hospital, Central South University, Changsha 410013, ChinaThis study aimed to establish a new clinical-radiomics nomogram based on ultrasound (US) for cervical lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC). We collected 211 patients with PTC between June 2018 and April 2020, then we randomly divided these patients into the training set (<i>n</i> = 148) and the validation set (<i>n</i> = 63). 837 radiomics features were extracted from B-mode ultrasound (BMUS) images and contrast-enhanced ultrasound (CEUS) images. The maximum relevance minimum redundancy (mRMR) algorithm, least absolute shrinkage and selection operator (LASSO) algorithm, and backward stepwise logistic regression (LR) were applied to select key features and establish a radiomics score (Radscore), including BMUS Radscore and CEUS Radscore. The clinical model and clinical-radiomics model were established using the univariate analysis and multivariate backward stepwise LR. The clinical-radiomics model was finally presented as a clinical-radiomics nomogram, the performance of which was evaluated by the receiver operating characteristic curves, Hosmer–Lemeshow test, calibration curves, and decision curve analysis (DCA). The results show that the clinical-radiomics nomogram was constructed by four predictors, including gender, age, US-reported LNM, and CEUS Radscore. The clinical-radiomics nomogram performed well in both the training set (AUC = 0.820) and the validation set (AUC = 0.814). The Hosmer–Lemeshow test and the calibration curves demonstrated good calibration. The DCA showed that the clinical-radiomics nomogram had satisfactory clinical utility. The clinical-radiomics nomogram constructed by CEUS Radscore and key clinical features can be used as an effective tool for individualized prediction of cervical LNM in PTC.https://www.mdpi.com/2072-6694/15/5/1613papillary thyroid carcinomacervical lymph node metastasisradiomicscontrast-enhanced ultrasoundnomogram |
| spellingShingle | Liqing Jiang Zijian Zhang Shiyan Guo Yongfeng Zhao Ping Zhou Clinical-Radiomics Nomogram Based on Contrast-Enhanced Ultrasound for Preoperative Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma Cancers papillary thyroid carcinoma cervical lymph node metastasis radiomics contrast-enhanced ultrasound nomogram |
| title | Clinical-Radiomics Nomogram Based on Contrast-Enhanced Ultrasound for Preoperative Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_full | Clinical-Radiomics Nomogram Based on Contrast-Enhanced Ultrasound for Preoperative Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_fullStr | Clinical-Radiomics Nomogram Based on Contrast-Enhanced Ultrasound for Preoperative Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_full_unstemmed | Clinical-Radiomics Nomogram Based on Contrast-Enhanced Ultrasound for Preoperative Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_short | Clinical-Radiomics Nomogram Based on Contrast-Enhanced Ultrasound for Preoperative Prediction of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma |
| title_sort | clinical radiomics nomogram based on contrast enhanced ultrasound for preoperative prediction of cervical lymph node metastasis in papillary thyroid carcinoma |
| topic | papillary thyroid carcinoma cervical lymph node metastasis radiomics contrast-enhanced ultrasound nomogram |
| url | https://www.mdpi.com/2072-6694/15/5/1613 |
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