Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal
The uterus is a highly innervated organ, and during labor, this innervation is at its highest level. Oxytocinergic fibers play an important role in labor and delivery and, in particular, the Lower Uterine Segment, cervix, and fundus are all controlled by motor neurofibers. Oxytocin is a neurohormone...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-03-01
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| Series: | European Journal of Obstetrics & Gynecology and Reproductive Biology: X |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590161323000996 |
| _version_ | 1797253944998625280 |
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| author | Antonio Malvasi Andrea Ballini Andrea Tinelli Bernard Fioretti Antonella Vimercati Elko Gliozheni Giorgio Maria Baldini Eliano Cascardi Miriam Dellino Monica Bonetti Ettore Cicinelli Amerigo Vitagliano Gianluca Raffaello Damiani |
| author_facet | Antonio Malvasi Andrea Ballini Andrea Tinelli Bernard Fioretti Antonella Vimercati Elko Gliozheni Giorgio Maria Baldini Eliano Cascardi Miriam Dellino Monica Bonetti Ettore Cicinelli Amerigo Vitagliano Gianluca Raffaello Damiani |
| author_sort | Antonio Malvasi |
| collection | DOAJ |
| description | The uterus is a highly innervated organ, and during labor, this innervation is at its highest level. Oxytocinergic fibers play an important role in labor and delivery and, in particular, the Lower Uterine Segment, cervix, and fundus are all controlled by motor neurofibers. Oxytocin is a neurohormone that acts on receptors located on the membrane of the smooth cells of the myometrium. During the stages of labor and delivery, its binding causes myofibers to contract, which enables the fundus of the uterus to act as a mediator. The aim of this study was to investigate the presence of oxytocinergic fibers in prolonged and non-prolonged dystocic delivery in a cohort of 90 patients, evaluated during the first and second stages of labor. Myometrial tissue samples were collected and evaluated by electron microscopy, in order to quantify differences in neurofibers concentrations between the investigated and control cohorts of patients. The authors of this experiment showed that the concentration of oxytocinergic fibers differs between non-prolonged and prolonged dystocic delivery. In particular, in prolonged dystocic delivery, compared to non-prolonged dystocic delivery, there is a lower amount of oxytocin fiber. The increase in oxytocin appeared to be ineffective in patients who experienced prolonged dystocic delivery, since the dystocic labor ended as a result of the altered presence of oxytocinergic fibers detected in this group of patients. |
| first_indexed | 2024-03-08T16:32:47Z |
| format | Article |
| id | doaj.art-f194bad1d0784419abebf2ebcf393071 |
| institution | Directory Open Access Journal |
| issn | 2590-1613 |
| language | English |
| last_indexed | 2024-04-24T21:42:07Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Obstetrics & Gynecology and Reproductive Biology: X |
| spelling | doaj.art-f194bad1d0784419abebf2ebcf3930712024-03-21T05:37:33ZengElsevierEuropean Journal of Obstetrics & Gynecology and Reproductive Biology: X2590-16132024-03-0121100273Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisalAntonio Malvasi0Andrea Ballini1Andrea Tinelli2Bernard Fioretti3Antonella Vimercati4Elko Gliozheni5Giorgio Maria Baldini6Eliano Cascardi7Miriam Dellino8Monica Bonetti9Ettore Cicinelli10Amerigo Vitagliano11Gianluca Raffaello Damiani12Department of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy; Unit of Obstetrics and Gynecology, University of Bari, Bari, ItalyDepartment of clinical and experimental medicine, University of Foggia, Foggia, 71122, ItalyDepartment of Obstetrics and Gynecology and CERICSAL (CEntro di RIcerca Clinico SALentino), Veris Delli Ponti Hospital, 73020 Scorrano, ItalyDepartment of Chemistry, Biology and Biotechnologies, University of Perugia, Via dell'Elce di Sotto 8, 06132 Perugia, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy; Unit of Obstetrics and Gynecology, University of Bari, Bari, ItalySection of Obstetrics and Gynecology, Department of Medicine and Surgery, University of Perugia, 06156 Perugia, Italy; University of Medicine of Tirana, Department of Obstetrics and Gynecology, Tirana, AlbaniaMomo Fertilife, IVF Clinic, Bisceglie, 76011, Italy; University of Bari Aldo Moro, 70121, Bari, ItalyDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari “Aldo Moro”, Policlinico of Bari, Piazza Giulio Cesare 11, 70124 Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy; Unit of Obstetrics and Gynecology, University of Bari, Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy; Unit of Obstetrics and Gynecology, University of Bari, Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy; Unit of Obstetrics and Gynecology, University of Bari, Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy; Unit of Obstetrics and Gynecology, University of Bari, Bari, ItalyDepartment of Biomedical Sciences and Human Oncology, University of Bari, 70121 Bari, Italy; Unit of Obstetrics and Gynecology, University of Bari, Bari, Italy; Correspondence to: Department of Obstetrics and Gynecology, University of Bari, Italy.The uterus is a highly innervated organ, and during labor, this innervation is at its highest level. Oxytocinergic fibers play an important role in labor and delivery and, in particular, the Lower Uterine Segment, cervix, and fundus are all controlled by motor neurofibers. Oxytocin is a neurohormone that acts on receptors located on the membrane of the smooth cells of the myometrium. During the stages of labor and delivery, its binding causes myofibers to contract, which enables the fundus of the uterus to act as a mediator. The aim of this study was to investigate the presence of oxytocinergic fibers in prolonged and non-prolonged dystocic delivery in a cohort of 90 patients, evaluated during the first and second stages of labor. Myometrial tissue samples were collected and evaluated by electron microscopy, in order to quantify differences in neurofibers concentrations between the investigated and control cohorts of patients. The authors of this experiment showed that the concentration of oxytocinergic fibers differs between non-prolonged and prolonged dystocic delivery. In particular, in prolonged dystocic delivery, compared to non-prolonged dystocic delivery, there is a lower amount of oxytocin fiber. The increase in oxytocin appeared to be ineffective in patients who experienced prolonged dystocic delivery, since the dystocic labor ended as a result of the altered presence of oxytocinergic fibers detected in this group of patients.http://www.sciencedirect.com/science/article/pii/S2590161323000996OxytocinNeurotransmittersNeurofibersDystociaProlonged laborOcciput posterior position |
| spellingShingle | Antonio Malvasi Andrea Ballini Andrea Tinelli Bernard Fioretti Antonella Vimercati Elko Gliozheni Giorgio Maria Baldini Eliano Cascardi Miriam Dellino Monica Bonetti Ettore Cicinelli Amerigo Vitagliano Gianluca Raffaello Damiani Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal European Journal of Obstetrics & Gynecology and Reproductive Biology: X Oxytocin Neurotransmitters Neurofibers Dystocia Prolonged labor Occiput posterior position |
| title | Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal |
| title_full | Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal |
| title_fullStr | Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal |
| title_full_unstemmed | Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal |
| title_short | Oxytocin augmentation and neurotransmitters in prolonged delivery: An experimental appraisal |
| title_sort | oxytocin augmentation and neurotransmitters in prolonged delivery an experimental appraisal |
| topic | Oxytocin Neurotransmitters Neurofibers Dystocia Prolonged labor Occiput posterior position |
| url | http://www.sciencedirect.com/science/article/pii/S2590161323000996 |
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