The prognostic role of γδ T cells in colorectal cancer based on nomogram
Abstract Objective The aim of the present study was to explore the prognostic role of γδ T cells in colorectal cancer, and establish a nomogram for predicting the survival of the patients. Methods Immunohistochemistry was performed to analyze the infiltration degree of γδ T cells in tumor and normal...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-023-01452-5 |
| _version_ | 1797647371234967552 |
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| author | Rulan Ma Meijun Gong Tuanhe Sun Lin Su Kang Li |
| author_facet | Rulan Ma Meijun Gong Tuanhe Sun Lin Su Kang Li |
| author_sort | Rulan Ma |
| collection | DOAJ |
| description | Abstract Objective The aim of the present study was to explore the prognostic role of γδ T cells in colorectal cancer, and establish a nomogram for predicting the survival of the patients. Methods Immunohistochemistry was performed to analyze the infiltration degree of γδ T cells in tumor and normal tissues of colorectal cancer. The relationship between γδ T cells infiltration in tumor tissues and the prognosis of patients with colorectal cancer were determined by Cox regression analysis and survival analysis. R software was used to establish and verify a nomogram for predicting the prognosis of patients with colorectal cancer. Results The degree of γδ T cell infiltration in tumor tissues and normal tissues of CRC was not different (t = 0.35, P = 0.73). However, the infiltration of γδ T cell was related to the survival status of the patients (x 2 = 4.88, P = 0.03). Besides, the infiltrating degree of γδ T cells in tumor tissue was obviously related to the prognostic improvement of the patients with colorectal cancer (log-rank P = 0.02) and could reflect the benefit of adjuvant chemotherapy. The nomogram based on tumor diameter, tumor location, AJCC stage, chemotherapy, serum CEA level and γδ T cell infiltration was established and could provide a reference for predicting the survival of colorectal cancer patients. Conclusion γδ T cell infiltration degree in tumor tissue was an important factor to improve the outcome of patients with colorectal cancer, and can predict the benefit of adjuvant chemotherapy. |
| first_indexed | 2024-03-11T15:16:20Z |
| format | Article |
| id | doaj.art-f194d2a8097f45f3923f8d439de6f650 |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-11T15:16:20Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-f194d2a8097f45f3923f8d439de6f6502023-10-29T12:18:36ZengBMCEuropean Journal of Medical Research2047-783X2023-10-012811810.1186/s40001-023-01452-5The prognostic role of γδ T cells in colorectal cancer based on nomogramRulan Ma0Meijun Gong1Tuanhe Sun2Lin Su3Kang Li4Department of Surgical Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Surgical Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Surgical Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityBiobank, The First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Surgical Oncology, The First Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Objective The aim of the present study was to explore the prognostic role of γδ T cells in colorectal cancer, and establish a nomogram for predicting the survival of the patients. Methods Immunohistochemistry was performed to analyze the infiltration degree of γδ T cells in tumor and normal tissues of colorectal cancer. The relationship between γδ T cells infiltration in tumor tissues and the prognosis of patients with colorectal cancer were determined by Cox regression analysis and survival analysis. R software was used to establish and verify a nomogram for predicting the prognosis of patients with colorectal cancer. Results The degree of γδ T cell infiltration in tumor tissues and normal tissues of CRC was not different (t = 0.35, P = 0.73). However, the infiltration of γδ T cell was related to the survival status of the patients (x 2 = 4.88, P = 0.03). Besides, the infiltrating degree of γδ T cells in tumor tissue was obviously related to the prognostic improvement of the patients with colorectal cancer (log-rank P = 0.02) and could reflect the benefit of adjuvant chemotherapy. The nomogram based on tumor diameter, tumor location, AJCC stage, chemotherapy, serum CEA level and γδ T cell infiltration was established and could provide a reference for predicting the survival of colorectal cancer patients. Conclusion γδ T cell infiltration degree in tumor tissue was an important factor to improve the outcome of patients with colorectal cancer, and can predict the benefit of adjuvant chemotherapy.https://doi.org/10.1186/s40001-023-01452-5Colorectal cancerγδ T cellPrognosisAdjuvant chemotherapyNomogram |
| spellingShingle | Rulan Ma Meijun Gong Tuanhe Sun Lin Su Kang Li The prognostic role of γδ T cells in colorectal cancer based on nomogram European Journal of Medical Research Colorectal cancer γδ T cell Prognosis Adjuvant chemotherapy Nomogram |
| title | The prognostic role of γδ T cells in colorectal cancer based on nomogram |
| title_full | The prognostic role of γδ T cells in colorectal cancer based on nomogram |
| title_fullStr | The prognostic role of γδ T cells in colorectal cancer based on nomogram |
| title_full_unstemmed | The prognostic role of γδ T cells in colorectal cancer based on nomogram |
| title_short | The prognostic role of γδ T cells in colorectal cancer based on nomogram |
| title_sort | prognostic role of γδ t cells in colorectal cancer based on nomogram |
| topic | Colorectal cancer γδ T cell Prognosis Adjuvant chemotherapy Nomogram |
| url | https://doi.org/10.1186/s40001-023-01452-5 |
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