Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study
ObjectivesTo describe the characteristics of patients between late-onset rheumatoid arthritis (LORA) with young-onset (YORA), and analyze their association with cumulative inflammatory burden.MethodsWe performed a nested cohort study in a prospective cohort comprising 110 patients with rheumatoid ar...
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.1016159/full |
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| author | Natalia Mena-Vázquez Natalia Mena-Vázquez Jose Manuel Lisbona-Montañez Jose Manuel Lisbona-Montañez Jose Manuel Lisbona-Montañez Rocío Redondo-Rodriguez Rocío Redondo-Rodriguez Rocío Redondo-Rodriguez Arkaitz Mucientes Arkaitz Mucientes Sara Manrique-Arija Sara Manrique-Arija Sara Manrique-Arija José Rioja José Rioja Aimara Garcia-Studer Aimara Garcia-Studer Fernando Ortiz-Márquez Fernando Ortiz-Márquez Laura Cano-García Laura Cano-García Antonio Fernández-Nebro Antonio Fernández-Nebro Antonio Fernández-Nebro |
| author_facet | Natalia Mena-Vázquez Natalia Mena-Vázquez Jose Manuel Lisbona-Montañez Jose Manuel Lisbona-Montañez Jose Manuel Lisbona-Montañez Rocío Redondo-Rodriguez Rocío Redondo-Rodriguez Rocío Redondo-Rodriguez Arkaitz Mucientes Arkaitz Mucientes Sara Manrique-Arija Sara Manrique-Arija Sara Manrique-Arija José Rioja José Rioja Aimara Garcia-Studer Aimara Garcia-Studer Fernando Ortiz-Márquez Fernando Ortiz-Márquez Laura Cano-García Laura Cano-García Antonio Fernández-Nebro Antonio Fernández-Nebro Antonio Fernández-Nebro |
| author_sort | Natalia Mena-Vázquez |
| collection | DOAJ |
| description | ObjectivesTo describe the characteristics of patients between late-onset rheumatoid arthritis (LORA) with young-onset (YORA), and analyze their association with cumulative inflammatory burden.MethodsWe performed a nested cohort study in a prospective cohort comprising 110 patients with rheumatoid arthritis (RA) and 110 age- and sex-matched controls. The main variable was cumulative inflammatory activity according to the 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR). High activity was defined as DAS28 ≥ 3.2 and low activity as DAS28 < 3.2. The other variables recorded were inflammatory cytokines, physical function, and comorbid conditions. Two multivariate models were run to identify factors associated with cumulative inflammatory activity.ResultsA total of 22/110 patients (20%) met the criteria for LORA (≥ 60 years). Patients with LORA more frequently had comorbid conditions than patients with YORA and controls. Compared with YORA patients, more LORA patients had cumulative high inflammatory activity from onset [13 (59%) vs. 28 (31%); p = 0.018] and high values for CRP (p = 0.039) and IL-6 (p = 0.045). Cumulative high inflammatory activity in patients with RA was associated with LORA [OR (95% CI) 4.69 (1.49–10.71); p = 0.008], smoking [OR (95% CI) 2.07 (1.13–3.78); p = 0.017], anti–citrullinated peptide antibody [OR (95% CI) 3.24 (1.15–9.13); p = 0.025], average Health Assessment Questionnaire (HAQ) score [OR (95% CI) 2.09 (1.03–14.23); p = 0.034], and physical activity [OR (95% CI) 0.99 (0.99–0.99); p = 0.010]. The second model revealed similar associations with inflammatory activity in patients with LORA.ConclusionControl of inflammation after diagnosis is poorer and comorbidity more frequent in patients with LORA than in YORA patients and healthy controls. |
| first_indexed | 2024-04-11T07:11:44Z |
| format | Article |
| id | doaj.art-f199760321a54332ad494dfc1b90e613 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-11T07:11:44Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-f199760321a54332ad494dfc1b90e6132022-12-22T04:38:11ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-11-01910.3389/fmed.2022.10161591016159Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort studyNatalia Mena-Vázquez0Natalia Mena-Vázquez1Jose Manuel Lisbona-Montañez2Jose Manuel Lisbona-Montañez3Jose Manuel Lisbona-Montañez4Rocío Redondo-Rodriguez5Rocío Redondo-Rodriguez6Rocío Redondo-Rodriguez7Arkaitz Mucientes8Arkaitz Mucientes9Sara Manrique-Arija10Sara Manrique-Arija11Sara Manrique-Arija12José Rioja13José Rioja14Aimara Garcia-Studer15Aimara Garcia-Studer16Fernando Ortiz-Márquez17Fernando Ortiz-Márquez18Laura Cano-García19Laura Cano-García20Antonio Fernández-Nebro21Antonio Fernández-Nebro22Antonio Fernández-Nebro23Instituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainDepartamento de Medicina y Dermatología, Universidad de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainDepartamento de Medicina y Dermatología, Universidad de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainDepartamento de Medicina y Dermatología, Universidad de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainDepartamento de Medicina y Dermatología, Universidad de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainInstituto de Investigación Biomédica de Málaga (IBIMA)-Plataforma Bionand, Málaga, SpainUnidad de Gestión Clínica (UGC) de Reumatología, Hospital Regional Universitario de Málaga, Málaga, SpainDepartamento de Medicina y Dermatología, Universidad de Málaga, Málaga, SpainObjectivesTo describe the characteristics of patients between late-onset rheumatoid arthritis (LORA) with young-onset (YORA), and analyze their association with cumulative inflammatory burden.MethodsWe performed a nested cohort study in a prospective cohort comprising 110 patients with rheumatoid arthritis (RA) and 110 age- and sex-matched controls. The main variable was cumulative inflammatory activity according to the 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR). High activity was defined as DAS28 ≥ 3.2 and low activity as DAS28 < 3.2. The other variables recorded were inflammatory cytokines, physical function, and comorbid conditions. Two multivariate models were run to identify factors associated with cumulative inflammatory activity.ResultsA total of 22/110 patients (20%) met the criteria for LORA (≥ 60 years). Patients with LORA more frequently had comorbid conditions than patients with YORA and controls. Compared with YORA patients, more LORA patients had cumulative high inflammatory activity from onset [13 (59%) vs. 28 (31%); p = 0.018] and high values for CRP (p = 0.039) and IL-6 (p = 0.045). Cumulative high inflammatory activity in patients with RA was associated with LORA [OR (95% CI) 4.69 (1.49–10.71); p = 0.008], smoking [OR (95% CI) 2.07 (1.13–3.78); p = 0.017], anti–citrullinated peptide antibody [OR (95% CI) 3.24 (1.15–9.13); p = 0.025], average Health Assessment Questionnaire (HAQ) score [OR (95% CI) 2.09 (1.03–14.23); p = 0.034], and physical activity [OR (95% CI) 0.99 (0.99–0.99); p = 0.010]. The second model revealed similar associations with inflammatory activity in patients with LORA.ConclusionControl of inflammation after diagnosis is poorer and comorbidity more frequent in patients with LORA than in YORA patients and healthy controls.https://www.frontiersin.org/articles/10.3389/fmed.2022.1016159/fulllate-onset rheumatoid arthritisyoung-onset rheumatoid arthritisaginginflammationearly rheumatoid arthritis |
| spellingShingle | Natalia Mena-Vázquez Natalia Mena-Vázquez Jose Manuel Lisbona-Montañez Jose Manuel Lisbona-Montañez Jose Manuel Lisbona-Montañez Rocío Redondo-Rodriguez Rocío Redondo-Rodriguez Rocío Redondo-Rodriguez Arkaitz Mucientes Arkaitz Mucientes Sara Manrique-Arija Sara Manrique-Arija Sara Manrique-Arija José Rioja José Rioja Aimara Garcia-Studer Aimara Garcia-Studer Fernando Ortiz-Márquez Fernando Ortiz-Márquez Laura Cano-García Laura Cano-García Antonio Fernández-Nebro Antonio Fernández-Nebro Antonio Fernández-Nebro Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study Frontiers in Medicine late-onset rheumatoid arthritis young-onset rheumatoid arthritis aging inflammation early rheumatoid arthritis |
| title | Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study |
| title_full | Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study |
| title_fullStr | Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study |
| title_full_unstemmed | Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study |
| title_short | Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study |
| title_sort | inflammatory profile of incident cases of late onset compared with young onset rheumatoid arthritis a nested cohort study |
| topic | late-onset rheumatoid arthritis young-onset rheumatoid arthritis aging inflammation early rheumatoid arthritis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.1016159/full |
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