Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity

Loss of protein kinase D activity demonstrates redundancy in cardiac glucose metabolism and preserves cardiac function in obesity

Objective: Protein kinase D (PKD) signaling has been implicated in stress-induced cardiac remodeling and function as well as metabolic processes including contraction-mediated cardiac glucose uptake. PKD has recently emerged as a nutrient-sensing kinase that is activated in high-lipid environments,...

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Bibliographic Details
Main Authors: Kirstie A. De Jong, Liam G. Hall, Mark C. Renton, Timothy Connor, Sheree D. Martin, Greg M. Kowalski, Christopher S. Shaw, Clinton R. Bruce, Kirsten F. Howlett, Sean L. McGee
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Metabolism
Subjects:
Protein kinase D
Cardiac glucose metabolism
Stable isotope metabolomics
Cardiac function
Obesity
Metabolic redundancy
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820301794

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