Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women
Overweight has been suggested to increase the risk of kidney stone formation. Although weight reduction might affect risk factors for urolithiasis, findings on the impact of different dietary weight loss strategies are limited. This randomized, controlled study evaluated the effect of a conventional...
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MDPI AG
2022-11-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/23/5054 |
| _version_ | 1797462553462308864 |
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| author | Roswitha Siener Charlotte Ernsten Norman Bitterlich Birgit Alteheld Christine Metzner |
| author_facet | Roswitha Siener Charlotte Ernsten Norman Bitterlich Birgit Alteheld Christine Metzner |
| author_sort | Roswitha Siener |
| collection | DOAJ |
| description | Overweight has been suggested to increase the risk of kidney stone formation. Although weight reduction might affect risk factors for urolithiasis, findings on the impact of different dietary weight loss strategies are limited. This randomized, controlled study evaluated the effect of a conventional energy-restricted modified diet with (MR group) or without meal replacement (C group) on risk factors for stone formation in overweight women without a history of urolithiasis. Of 105 participants, 78 were included into the per-protocol analysis. Anthropometric, clinical, biochemical, and 24 h urinary parameters were collected at baseline and after 12 weeks. Although both dietary interventions resulted in a significant weight reduction, relative weight loss and rate of responders were higher in the MR group. Weight loss improved cardiometabolic risk profile in both groups. Unfortunately, the benefit of decreased GPT activity in the C group was offset by a significant increase in homocysteine and a decline in GFR. While the relative supersaturation of calcium oxalate decreased significantly in both groups, a significant decline in serum uric acid concentration and relative supersaturation of uric acid was observed only in the MR group. Finally, the energy-restricted modified diet with meal replacement showed significant advantages over the energy-restricted modified diet alone. |
| first_indexed | 2024-03-09T17:38:13Z |
| format | Article |
| id | doaj.art-f19acb6eebc64f39937d238ce3e7f0b3 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T17:38:13Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f19acb6eebc64f39937d238ce3e7f0b32023-11-24T11:51:22ZengMDPI AGNutrients2072-66432022-11-011423505410.3390/nu14235054Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight WomenRoswitha Siener0Charlotte Ernsten1Norman Bitterlich2Birgit Alteheld3Christine Metzner4University Stone Center, Department of Urology, University Hospital Bonn, 53127 Bonn, GermanyUniversity Stone Center, Department of Urology, University Hospital Bonn, 53127 Bonn, GermanyIndependent Biostatistician, Draisdorfer Str. 21, 09114 Chemnitz, GermanyDepartment of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, 53115 Bonn, GermanyBonn Education Association for Dietetics r. A., 50935 Cologne, GermanyOverweight has been suggested to increase the risk of kidney stone formation. Although weight reduction might affect risk factors for urolithiasis, findings on the impact of different dietary weight loss strategies are limited. This randomized, controlled study evaluated the effect of a conventional energy-restricted modified diet with (MR group) or without meal replacement (C group) on risk factors for stone formation in overweight women without a history of urolithiasis. Of 105 participants, 78 were included into the per-protocol analysis. Anthropometric, clinical, biochemical, and 24 h urinary parameters were collected at baseline and after 12 weeks. Although both dietary interventions resulted in a significant weight reduction, relative weight loss and rate of responders were higher in the MR group. Weight loss improved cardiometabolic risk profile in both groups. Unfortunately, the benefit of decreased GPT activity in the C group was offset by a significant increase in homocysteine and a decline in GFR. While the relative supersaturation of calcium oxalate decreased significantly in both groups, a significant decline in serum uric acid concentration and relative supersaturation of uric acid was observed only in the MR group. Finally, the energy-restricted modified diet with meal replacement showed significant advantages over the energy-restricted modified diet alone.https://www.mdpi.com/2072-6643/14/23/5054kidney stonesurolithiasiscalcium oxalateuric acidobesitymetabolic syndrome |
| spellingShingle | Roswitha Siener Charlotte Ernsten Norman Bitterlich Birgit Alteheld Christine Metzner Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women Nutrients kidney stones urolithiasis calcium oxalate uric acid obesity metabolic syndrome |
| title | Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women |
| title_full | Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women |
| title_fullStr | Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women |
| title_full_unstemmed | Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women |
| title_short | Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women |
| title_sort | effect of two different dietary weight loss strategies on risk factors for urinary stone formation and cardiometabolic risk profile in overweight women |
| topic | kidney stones urolithiasis calcium oxalate uric acid obesity metabolic syndrome |
| url | https://www.mdpi.com/2072-6643/14/23/5054 |
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