Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia
The perinatal hypoxia (PH) in preterm newborns is associated with elevated levels of matrix metalloproteinase 9 (MMP-9), superoxide dismutase (SOD) and thiobarbituric acid reactive substances in umbilical cord blood plasma. The severity of PH Apgar scores correlated with SOD (r = –0,40; p = 0,006) a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2011-04-01
|
| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1354 |
| _version_ | 1797873143217389568 |
|---|---|
| author | Yu. V. Korenovsky S. A. Elchaninova N. I. Fadeyeva |
| author_facet | Yu. V. Korenovsky S. A. Elchaninova N. I. Fadeyeva |
| author_sort | Yu. V. Korenovsky |
| collection | DOAJ |
| description | The perinatal hypoxia (PH) in preterm newborns is associated with elevated levels of matrix metalloproteinase 9 (MMP-9), superoxide dismutase (SOD) and thiobarbituric acid reactive substances in umbilical cord blood plasma. The severity of PH Apgar scores correlated with SOD (r = –0,40; p = 0,006) and MMP-9 (r = 0,36; p = 0,023). It is assumed that the SOD increase prevents the reactive oxygen species mediated activation of MMP-9, which destroy the collagen of the basement membrane of the bloodbrain barrier. |
| first_indexed | 2024-04-10T01:10:23Z |
| format | Article |
| id | doaj.art-f19ed618b6b54dd093a9c3bb8b5fcc13 |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:10:23Z |
| publishDate | 2011-04-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-f19ed618b6b54dd093a9c3bb8b5fcc132023-03-13T09:58:14ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842011-04-01102262910.20538/1682-0363-2011-2-26-29868Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxiaYu. V. Korenovsky0S. A. Elchaninova1N. I. Fadeyeva2Алтайский государственный медицинский университетАлтайский государственный медицинский университетАлтайский государственный медицинский университетThe perinatal hypoxia (PH) in preterm newborns is associated with elevated levels of matrix metalloproteinase 9 (MMP-9), superoxide dismutase (SOD) and thiobarbituric acid reactive substances in umbilical cord blood plasma. The severity of PH Apgar scores correlated with SOD (r = –0,40; p = 0,006) and MMP-9 (r = 0,36; p = 0,023). It is assumed that the SOD increase prevents the reactive oxygen species mediated activation of MMP-9, which destroy the collagen of the basement membrane of the bloodbrain barrier.https://bulletin.ssmu.ru/jour/article/view/1354перинатальная гипоксиясупероксиддисмутазаматриксная металлопротеиназа-9 |
| spellingShingle | Yu. V. Korenovsky S. A. Elchaninova N. I. Fadeyeva Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia Бюллетень сибирской медицины перинатальная гипоксия супероксиддисмутаза матриксная металлопротеиназа-9 |
| title | Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia |
| title_full | Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia |
| title_fullStr | Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia |
| title_full_unstemmed | Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia |
| title_short | Matrix metalloproteinase 9, superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia |
| title_sort | matrix metalloproteinase 9 superoxide dismutase and lipid peroxidation in preterm newborns with perinatal hypoxia |
| topic | перинатальная гипоксия супероксиддисмутаза матриксная металлопротеиназа-9 |
| url | https://bulletin.ssmu.ru/jour/article/view/1354 |
| work_keys_str_mv | AT yuvkorenovsky matrixmetalloproteinase9superoxidedismutaseandlipidperoxidationinpretermnewbornswithperinatalhypoxia AT saelchaninova matrixmetalloproteinase9superoxidedismutaseandlipidperoxidationinpretermnewbornswithperinatalhypoxia AT nifadeyeva matrixmetalloproteinase9superoxidedismutaseandlipidperoxidationinpretermnewbornswithperinatalhypoxia |