Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase.

Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase.

The association of B7-1/CD28 between antigen presenting cells (APCs) and T-cells provides a second signal to proliferate and activate T-cell immunity at the induction phase. Many reports indicate that tumor cells transfected with B7-1 induced augmented antitumor immunity at the induction phase by mi...

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Bibliographic Details
Main Authors: Xiao-Lin Li, Marjolein Sluijter, Elien M Doorduijn, Shubha P Kale, Harris McFerrin, Yong-Yu Liu, Yan Li, Madhusoodanan Mottamal, Xin Yao, Fengkun Du, Baihan Gu, Kim Hoang, Yen H Nguyen, Nichelle Taylor, Chelsea R Stephens, Thorbald van Hall, Qian-Jin Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4226464?pdf=render

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