Evidence for an association of <it>HLA-DRB1*15 </it>and <it>DRB1*09 </it>with leprosy and the impact of <it>DRB1*09 </it>on disease onset in a Chinese Han population
<p>Abstract</p> <p>Background</p> <p>Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to <it>Mycobacterium leprae</it>. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese...
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| Format: | Article |
| Language: | English |
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BMC
2009-12-01
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| Series: | BMC Medical Genetics |
| Online Access: | http://www.biomedcentral.com/1471-2350/10/133 |
| _version_ | 1818897520368025600 |
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| author | Chu Tongsheng Zhang Lin Zhu Chuanfu Wang Changyuan Chen Shumin Liu Hong Zhang Furen Liu Dianchang Yan Xiaoxiao Liu Jianjun |
| author_facet | Chu Tongsheng Zhang Lin Zhu Chuanfu Wang Changyuan Chen Shumin Liu Hong Zhang Furen Liu Dianchang Yan Xiaoxiao Liu Jianjun |
| author_sort | Chu Tongsheng |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to <it>Mycobacterium leprae</it>. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population.</p> <p>Methods</p> <p>The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals.</p> <p>Results</p> <p>The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease.</p> <p>Conclusion</p> <p>HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.</p> |
| first_indexed | 2024-12-19T19:17:29Z |
| format | Article |
| id | doaj.art-f1a1607f74734e51b4a95ebc8461a799 |
| institution | Directory Open Access Journal |
| issn | 1471-2350 |
| language | English |
| last_indexed | 2024-12-19T19:17:29Z |
| publishDate | 2009-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medical Genetics |
| spelling | doaj.art-f1a1607f74734e51b4a95ebc8461a7992022-12-21T20:09:06ZengBMCBMC Medical Genetics1471-23502009-12-0110113310.1186/1471-2350-10-133Evidence for an association of <it>HLA-DRB1*15 </it>and <it>DRB1*09 </it>with leprosy and the impact of <it>DRB1*09 </it>on disease onset in a Chinese Han populationChu TongshengZhang LinZhu ChuanfuWang ChangyuanChen ShuminLiu HongZhang FurenLiu DianchangYan XiaoxiaoLiu Jianjun<p>Abstract</p> <p>Background</p> <p>Human leukocyte antigens (HLAs) have been proposed to modulate the immune response to <it>Mycobacterium leprae</it>. The association of HLA-DRB1 with leprosy has been reported in several populations, but not in a Chinese population.</p> <p>Methods</p> <p>The polymerase chain reaction-sequence-specific oligonucleotide probe with Luminex100 (PCR-SSOP-Luminex) method was used to genotype HLA-DRB1 alleles in 305 leprosy patients and 527 healthy control individuals.</p> <p>Results</p> <p>The HLA-DRB1*15 allele was significantly more prevalent among leprosy patients than healthy controls, whereas the frequency of the HLA-DRB1*09 allele was lower among leprosy patients, especially those with early-onset disease.</p> <p>Conclusion</p> <p>HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. The HLA-DRB1*09 allele was found to be protective exclusively in a subset of early-onset leprosy patients.</p>http://www.biomedcentral.com/1471-2350/10/133 |
| spellingShingle | Chu Tongsheng Zhang Lin Zhu Chuanfu Wang Changyuan Chen Shumin Liu Hong Zhang Furen Liu Dianchang Yan Xiaoxiao Liu Jianjun Evidence for an association of <it>HLA-DRB1*15 </it>and <it>DRB1*09 </it>with leprosy and the impact of <it>DRB1*09 </it>on disease onset in a Chinese Han population BMC Medical Genetics |
| title | Evidence for an association of <it>HLA-DRB1*15 </it>and <it>DRB1*09 </it>with leprosy and the impact of <it>DRB1*09 </it>on disease onset in a Chinese Han population |
| title_full | Evidence for an association of <it>HLA-DRB1*15 </it>and <it>DRB1*09 </it>with leprosy and the impact of <it>DRB1*09 </it>on disease onset in a Chinese Han population |
| title_fullStr | Evidence for an association of <it>HLA-DRB1*15 </it>and <it>DRB1*09 </it>with leprosy and the impact of <it>DRB1*09 </it>on disease onset in a Chinese Han population |
| title_full_unstemmed | Evidence for an association of <it>HLA-DRB1*15 </it>and <it>DRB1*09 </it>with leprosy and the impact of <it>DRB1*09 </it>on disease onset in a Chinese Han population |
| title_short | Evidence for an association of <it>HLA-DRB1*15 </it>and <it>DRB1*09 </it>with leprosy and the impact of <it>DRB1*09 </it>on disease onset in a Chinese Han population |
| title_sort | evidence for an association of it hla drb1 15 it and it drb1 09 it with leprosy and the impact of it drb1 09 it on disease onset in a chinese han population |
| url | http://www.biomedcentral.com/1471-2350/10/133 |
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