Preventive Therapies in Peripheral Arterial Disease
Atherosclerosis, while initially deemed a bland proliferative process, is now recognized as a multifactorial-lipoprotein-mediated inflammation-driven pathway. With the rising incidence of atherosclerotic disease of the lower extremity arteries, the healthcare burden and clinical morbidity and mortal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/11/12/3157 |
| _version_ | 1797382003722551296 |
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| author | Aangi J. Shah Nicholas Pavlatos Dinesh K. Kalra |
| author_facet | Aangi J. Shah Nicholas Pavlatos Dinesh K. Kalra |
| author_sort | Aangi J. Shah |
| collection | DOAJ |
| description | Atherosclerosis, while initially deemed a bland proliferative process, is now recognized as a multifactorial-lipoprotein-mediated inflammation-driven pathway. With the rising incidence of atherosclerotic disease of the lower extremity arteries, the healthcare burden and clinical morbidity and mortality due to peripheral artery disease (PAD) are currently escalating. With a healthcare cost burden of over 21 billion USD and 200 million patients afflicted worldwide, accurate knowledge regarding the pathophysiology, presentation, and diagnosis of the disease is crucial. The role of lipoproteins and their remnants in atherosclerotic vessel occlusion and plaque formation and progression has been long established. This review paper discusses the epidemiology, pathophysiology, and presentation of PAD. PAD has been repeatedly noted to portend to poor cardiovascular and limb outcomes. We discuss major therapeutic avenues for the prevention of major cardiovascular adverse events and major limb adverse events in patients with PAD. |
| first_indexed | 2024-03-08T20:59:13Z |
| format | Article |
| id | doaj.art-f1a17ab77e734e0794a04922d9c52b81 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-08T20:59:13Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f1a17ab77e734e0794a04922d9c52b812023-12-22T13:54:49ZengMDPI AGBiomedicines2227-90592023-11-011112315710.3390/biomedicines11123157Preventive Therapies in Peripheral Arterial DiseaseAangi J. Shah0Nicholas Pavlatos1Dinesh K. Kalra2Department of Internal Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USADepartment of Internal Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USADivision of Cardiology, University of Louisville School of Medicine, Louisville, KY 40202, USAAtherosclerosis, while initially deemed a bland proliferative process, is now recognized as a multifactorial-lipoprotein-mediated inflammation-driven pathway. With the rising incidence of atherosclerotic disease of the lower extremity arteries, the healthcare burden and clinical morbidity and mortality due to peripheral artery disease (PAD) are currently escalating. With a healthcare cost burden of over 21 billion USD and 200 million patients afflicted worldwide, accurate knowledge regarding the pathophysiology, presentation, and diagnosis of the disease is crucial. The role of lipoproteins and their remnants in atherosclerotic vessel occlusion and plaque formation and progression has been long established. This review paper discusses the epidemiology, pathophysiology, and presentation of PAD. PAD has been repeatedly noted to portend to poor cardiovascular and limb outcomes. We discuss major therapeutic avenues for the prevention of major cardiovascular adverse events and major limb adverse events in patients with PAD.https://www.mdpi.com/2227-9059/11/12/3157peripheral artery diseaselipidsatherosclerosispreventionmajor adverse cardiovascular eventslipid-lowering therapy |
| spellingShingle | Aangi J. Shah Nicholas Pavlatos Dinesh K. Kalra Preventive Therapies in Peripheral Arterial Disease Biomedicines peripheral artery disease lipids atherosclerosis prevention major adverse cardiovascular events lipid-lowering therapy |
| title | Preventive Therapies in Peripheral Arterial Disease |
| title_full | Preventive Therapies in Peripheral Arterial Disease |
| title_fullStr | Preventive Therapies in Peripheral Arterial Disease |
| title_full_unstemmed | Preventive Therapies in Peripheral Arterial Disease |
| title_short | Preventive Therapies in Peripheral Arterial Disease |
| title_sort | preventive therapies in peripheral arterial disease |
| topic | peripheral artery disease lipids atherosclerosis prevention major adverse cardiovascular events lipid-lowering therapy |
| url | https://www.mdpi.com/2227-9059/11/12/3157 |
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