Tyrp1 Mutant Variants Associated with OCA3: Computational Characterization of Protein Stability and Ligand Binding
Oculocutaneous albinism type 3 (OCA3) is an autosomal recessive disorder caused by mutations in the <i>TYRP1</i> gene. Tyrosinase-related protein 1 (Tyrp1) is involved in eumelanin synthesis, catalyzing the oxidation of 5,6-dihydroxyindole-2-carboxylic acid oxidase (DHICA) to 5,6-indoleq...
Main Authors: | Milan H. Patel, Monika B. Dolinska, Yuri V. Sergeev |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-09-01
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Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/22/19/10203 |
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