Characterization of Corosolic Acid as a KPC-2 Inhibitor That Increases the Susceptibility of KPC-2-Positive Bacteria to Carbapenems

Characterization of Corosolic Acid as a KPC-2 Inhibitor That Increases the Susceptibility of KPC-2-Positive Bacteria to Carbapenems

The emergence of KPC-producing Gram-negative bacteria in clinical practice highlights the need to search for novel antimicrobials and new anti-infection strategies. In this study, we constructed a laboratory KPC-2-positive strain, E. coli BL21(DE3) (pET28a-KPC-2) and identified the activity of KPC-2...

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Bibliographic Details
Main Authors: Yonglin Zhou, Xiaohong Lv, Meishan Chen, Yan Guo, Rui Ding, Bin Liu, Xuming Deng, Jianfeng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
KPC-2
corosolic acid
carbapenems
anti-infection
Enterobacteriaceae
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01047/full

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