Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

Functional role of the type 1 pilus rod structure in mediating host-pathogen interactions

Uropathogenic E. coli (UPEC), which cause urinary tract infections (UTI), utilize type 1 pili, a chaperone usher pathway (CUP) pilus, to cause UTI and colonize the gut. The pilus rod, comprised of repeating FimA subunits, provides a structural scaffold for displaying the tip adhesin, FimH. We solved...

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Detalles Bibliográficos
Main Authors: Caitlin N Spaulding, Henry Louis Schreiber IV, Weili Zheng, Karen W Dodson, Jennie E Hazen, Matt S Conover, Fengbin Wang, Pontus Svenmarker, Areli Luna-Rico, Olivera Francetic, Magnus Andersson, Scott Hultgren, Edward H Egelman
Formato: Artigo
Idioma:English
Publicado: eLife Sciences Publications Ltd 2018-01-01
Series:eLife
Subjects:
Chaperone-usher pathway pili
CUP pili
type 1 pili
cryo-EM
UPEC
UTI
Acceso en liña:https://elifesciences.org/articles/31662

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