Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal Diseases
Background and aims. Melatonin is a circulating hormone that is mainly released from the pineal gland. It possesses antioxidant, free-radical scavenging, and immune-enhancing properties. A growing number of studies reveal a complex role for melatonin in influencing various diseases, including diabet...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2014-09-01
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| Series: | Journal of Dental Research, Dental Clinics, Dental Prospects |
| Subjects: | |
| Online Access: | http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/1162/406 |
| _version_ | 1819052942735441920 |
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| author | Hamidreza Abdolsamadi Mohammad Taghi Goodarzi Fatemeh Ahmadi Motemayel Mina Jazaeri Javad Feradmal Mahdiyeh Zarabadi Mostafa Hoseyni Parviz Torkzaban |
| author_facet | Hamidreza Abdolsamadi Mohammad Taghi Goodarzi Fatemeh Ahmadi Motemayel Mina Jazaeri Javad Feradmal Mahdiyeh Zarabadi Mostafa Hoseyni Parviz Torkzaban |
| author_sort | Hamidreza Abdolsamadi |
| collection | DOAJ |
| description | Background and aims. Melatonin is a circulating hormone that is mainly released from the pineal gland. It possesses antioxidant, free-radical scavenging, and immune-enhancing properties. A growing number of studies reveal a complex role for melatonin in influencing various diseases, including diabetes and periodontal diseases. The aim of this study was to ex-amine the possible links between salivary melatonin levels and type II diabetes and periodontal diseases.
Materials and methods. A total of 30 type II diabetic patients, 30 patients with periodontal diseases, 30 type II diabetic patients with periodontal disease and 30 age- and BMI-matched controls were studied. The periodontal status was evaluated by the Community Periodontal Index (CPI). Salivary melatonin levels were determined by a commercial enzyme-linked immunosorbent assay (ELISA) kit.
Results. The mean of salivary melatonin level was significantly lower in patients with either periodontitis or diabetes com-pared to healthy subjects (P < 0.05). Salivary melatonin concentration decreased in type II diabetic patients and periodontitis patients, and then decreased reaching the lowest levels in type II diabetic patients with periodontal disease.
Conclusion. Based on the results of this study, it can probably be concluded that salivary level of melatonin has an impor-tant role in the pathogenesis of diabetes and periodontal diseases. It is also worth noting that this factor could probably be used as a pivotal biological marker in the diagnosis and possible treatment of these diseases, although further research is required to validate this hypothesis. |
| first_indexed | 2024-12-21T12:27:51Z |
| format | Article |
| id | doaj.art-f1a4670a85b747819f05009e3aee6e6a |
| institution | Directory Open Access Journal |
| issn | 2008-210X 2008-2118 |
| language | English |
| last_indexed | 2024-12-21T12:27:51Z |
| publishDate | 2014-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Dental Research, Dental Clinics, Dental Prospects |
| spelling | doaj.art-f1a4670a85b747819f05009e3aee6e6a2022-12-21T19:04:08ZengTabriz University of Medical SciencesJournal of Dental Research, Dental Clinics, Dental Prospects2008-210X2008-21182014-09-018316016510.5681/joddd.2014.029Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal DiseasesHamidreza Abdolsamadi0Mohammad Taghi Goodarzi1Fatemeh Ahmadi Motemayel2Mina Jazaeri3Javad Feradmal4Mahdiyeh Zarabadi5Mostafa Hoseyni6Parviz Torkzaban7Professor, Department of Oral Medicine, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, IranProfessor, Department of Oral Medicine, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, IranProfessor, Department of Biochemistry and Nutrition, Research Center for Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranAssistant Professor, Department of Oral Medicine, Faculty of Dentistry, Hamadan University of Medical Sciences, Hamadan, IranDepartment of Biostatistics and Epidemiology, School of Public Health, Hamadan University of Medical Sciences, Hamadan, IranPostgraduate Student, Department of Oral Medicine, Hamadan University of Medical Sciences, Haman, IranStudent of Biochemistry and Nutrition, School of Medicine, Hamadan University of Medical Sciences, Hamadan, IranAssociate Professor, Department of Periodontology, Dental Research Center, Hamadan University of Medical Sciences, Hamadan, IranBackground and aims. Melatonin is a circulating hormone that is mainly released from the pineal gland. It possesses antioxidant, free-radical scavenging, and immune-enhancing properties. A growing number of studies reveal a complex role for melatonin in influencing various diseases, including diabetes and periodontal diseases. The aim of this study was to ex-amine the possible links between salivary melatonin levels and type II diabetes and periodontal diseases. Materials and methods. A total of 30 type II diabetic patients, 30 patients with periodontal diseases, 30 type II diabetic patients with periodontal disease and 30 age- and BMI-matched controls were studied. The periodontal status was evaluated by the Community Periodontal Index (CPI). Salivary melatonin levels were determined by a commercial enzyme-linked immunosorbent assay (ELISA) kit. Results. The mean of salivary melatonin level was significantly lower in patients with either periodontitis or diabetes com-pared to healthy subjects (P < 0.05). Salivary melatonin concentration decreased in type II diabetic patients and periodontitis patients, and then decreased reaching the lowest levels in type II diabetic patients with periodontal disease. Conclusion. Based on the results of this study, it can probably be concluded that salivary level of melatonin has an impor-tant role in the pathogenesis of diabetes and periodontal diseases. It is also worth noting that this factor could probably be used as a pivotal biological marker in the diagnosis and possible treatment of these diseases, although further research is required to validate this hypothesis.http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/1162/406Iranmelatoninperiodontal diseasesalivatype II diabetes |
| spellingShingle | Hamidreza Abdolsamadi Mohammad Taghi Goodarzi Fatemeh Ahmadi Motemayel Mina Jazaeri Javad Feradmal Mahdiyeh Zarabadi Mostafa Hoseyni Parviz Torkzaban Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal Diseases Journal of Dental Research, Dental Clinics, Dental Prospects Iran melatonin periodontal disease saliva type II diabetes |
| title | Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal Diseases |
| title_full | Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal Diseases |
| title_fullStr | Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal Diseases |
| title_full_unstemmed | Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal Diseases |
| title_short | Reduction of Melatonin Level in Patients with Type II Diabetes and Periodontal Diseases |
| title_sort | reduction of melatonin level in patients with type ii diabetes and periodontal diseases |
| topic | Iran melatonin periodontal disease saliva type II diabetes |
| url | http://dentistry.tbzmed.ac.ir/joddd/index.php/joddd/article/view/1162/406 |
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