Association of Pretreatment Physical and Geriatric Parameters with Treatment Tolerance and Survival in Elderly Patients with Stage I–II Non-Small Cell Lung Cancer: An Evaluation of Usual Care Data
In this study, the association of pretreatment physical and geriatric parameters with treatment tolerance and survival in elderly patients with stage I–II NSCLC was evaluated. Retrospective data for patients aged ≥70 years, diagnosed between 2016 and 2020 with stage I–II NSCLC, and who underwent sur...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/23/5994 |
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| author | Melissa J. J. Voorn Merle F. R. Bootsma Gerben P. Bootsma Vivian E. M. van Kampen-van den Boogaart Geerten J. A. van Riet Dirk K. de Ruysscher Bart C. Bongers Maryska L. G. Janssen-Heijnen |
| author_facet | Melissa J. J. Voorn Merle F. R. Bootsma Gerben P. Bootsma Vivian E. M. van Kampen-van den Boogaart Geerten J. A. van Riet Dirk K. de Ruysscher Bart C. Bongers Maryska L. G. Janssen-Heijnen |
| author_sort | Melissa J. J. Voorn |
| collection | DOAJ |
| description | In this study, the association of pretreatment physical and geriatric parameters with treatment tolerance and survival in elderly patients with stage I–II NSCLC was evaluated. Retrospective data for patients aged ≥70 years, diagnosed between 2016 and 2020 with stage I–II NSCLC, and who underwent surgery or stereotactic ablative radiotherapy (SABR) in a large Dutch teaching hospital were retrieved from medical records. Associations of pretreatment physical and geriatric parameters with treatment tolerance and survival were analyzed. Of 160 patients, 49 of 104 (47%) patients who underwent surgery and 21 of 56 (38%) patients who received SABR did not tolerate treatment. In univariable analysis, World Health Organization (WHO) performance status ≥ 2, short nutritional assessment questionnaire score > 1, short physical performance battery score ≤ 9, and geriatric-8 score ≤ 14 were significantly associated with postoperative complications. Forced expiratory volume of one second < 80% of predicted was significantly associated with intolerance of SABR. In multivariable analysis, WHO performance status ≥ 2 and diffusing capacity for carbon monoxide < 80% were significantly associated with decreased overall survival. This is the first study that investigated the association between pretreatment physical and geriatric parameters and treatment outcomes in patients with stage I–II NSCLC. Evaluation of physical and geriatric parameters before treatment initiation seems highly recommended to select patients who might benefit from preventive interventions before and/or during treatment. |
| first_indexed | 2024-03-09T17:51:51Z |
| format | Article |
| id | doaj.art-f1a4dfe2e9554d86a86b2b2b7862ad1f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T17:51:51Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-f1a4dfe2e9554d86a86b2b2b7862ad1f2023-11-24T10:42:04ZengMDPI AGCancers2072-66942022-12-011423599410.3390/cancers14235994Association of Pretreatment Physical and Geriatric Parameters with Treatment Tolerance and Survival in Elderly Patients with Stage I–II Non-Small Cell Lung Cancer: An Evaluation of Usual Care DataMelissa J. J. Voorn0Merle F. R. Bootsma1Gerben P. Bootsma2Vivian E. M. van Kampen-van den Boogaart3Geerten J. A. van Riet4Dirk K. de Ruysscher5Bart C. Bongers6Maryska L. G. Janssen-Heijnen7Department of Clinical Epidemiology, VieCuri Medical Center, 5912 BL Venlo, The NetherlandsDepartment of Pulmonology, Zuyderland Medical Center, 6419 PC Heerlen, The NetherlandsDepartment of Pulmonology, Zuyderland Medical Center, 6419 PC Heerlen, The NetherlandsDepartment of Pulmonology, VieCuri Medical Center, 5912 BL Venlo, The NetherlandsDepartment of Geriatrics, Zuyderland Medical Center, 6419 PC Heerlen, The NetherlandsDepartment of Radiation Oncology (MAASTRO Clinic), GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD Maastricht, The NetherlandsDepartment of Nutrition and Movement Sciences, Nutrition and Translational Research in Metabolism (NUTRIM), Faculty of Health, Medicine and Life Sciences, Maastricht University, 6200 MD Maastricht, The NetherlandsDepartment of Clinical Epidemiology, VieCuri Medical Center, 5912 BL Venlo, The NetherlandsIn this study, the association of pretreatment physical and geriatric parameters with treatment tolerance and survival in elderly patients with stage I–II NSCLC was evaluated. Retrospective data for patients aged ≥70 years, diagnosed between 2016 and 2020 with stage I–II NSCLC, and who underwent surgery or stereotactic ablative radiotherapy (SABR) in a large Dutch teaching hospital were retrieved from medical records. Associations of pretreatment physical and geriatric parameters with treatment tolerance and survival were analyzed. Of 160 patients, 49 of 104 (47%) patients who underwent surgery and 21 of 56 (38%) patients who received SABR did not tolerate treatment. In univariable analysis, World Health Organization (WHO) performance status ≥ 2, short nutritional assessment questionnaire score > 1, short physical performance battery score ≤ 9, and geriatric-8 score ≤ 14 were significantly associated with postoperative complications. Forced expiratory volume of one second < 80% of predicted was significantly associated with intolerance of SABR. In multivariable analysis, WHO performance status ≥ 2 and diffusing capacity for carbon monoxide < 80% were significantly associated with decreased overall survival. This is the first study that investigated the association between pretreatment physical and geriatric parameters and treatment outcomes in patients with stage I–II NSCLC. Evaluation of physical and geriatric parameters before treatment initiation seems highly recommended to select patients who might benefit from preventive interventions before and/or during treatment.https://www.mdpi.com/2072-6694/14/23/5994lung cancerpretreatment risk assessmentphysical performancegeriatric assessmenttreatment toleranceprehabilitation |
| spellingShingle | Melissa J. J. Voorn Merle F. R. Bootsma Gerben P. Bootsma Vivian E. M. van Kampen-van den Boogaart Geerten J. A. van Riet Dirk K. de Ruysscher Bart C. Bongers Maryska L. G. Janssen-Heijnen Association of Pretreatment Physical and Geriatric Parameters with Treatment Tolerance and Survival in Elderly Patients with Stage I–II Non-Small Cell Lung Cancer: An Evaluation of Usual Care Data Cancers lung cancer pretreatment risk assessment physical performance geriatric assessment treatment tolerance prehabilitation |
| title | Association of Pretreatment Physical and Geriatric Parameters with Treatment Tolerance and Survival in Elderly Patients with Stage I–II Non-Small Cell Lung Cancer: An Evaluation of Usual Care Data |
| title_full | Association of Pretreatment Physical and Geriatric Parameters with Treatment Tolerance and Survival in Elderly Patients with Stage I–II Non-Small Cell Lung Cancer: An Evaluation of Usual Care Data |
| title_fullStr | Association of Pretreatment Physical and Geriatric Parameters with Treatment Tolerance and Survival in Elderly Patients with Stage I–II Non-Small Cell Lung Cancer: An Evaluation of Usual Care Data |
| title_full_unstemmed | Association of Pretreatment Physical and Geriatric Parameters with Treatment Tolerance and Survival in Elderly Patients with Stage I–II Non-Small Cell Lung Cancer: An Evaluation of Usual Care Data |
| title_short | Association of Pretreatment Physical and Geriatric Parameters with Treatment Tolerance and Survival in Elderly Patients with Stage I–II Non-Small Cell Lung Cancer: An Evaluation of Usual Care Data |
| title_sort | association of pretreatment physical and geriatric parameters with treatment tolerance and survival in elderly patients with stage i ii non small cell lung cancer an evaluation of usual care data |
| topic | lung cancer pretreatment risk assessment physical performance geriatric assessment treatment tolerance prehabilitation |
| url | https://www.mdpi.com/2072-6694/14/23/5994 |
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