microRNA-33 controls hunger signaling in hypothalamic AgRP neurons
Abstract AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established, the role of microRNAs in this process is poorly understood. Utilizing uniq...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2024-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-46427-0 |
| _version_ | 1797266736406331392 |
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| author | Nathan L. Price Pablo Fernández-Tussy Luis Varela Magdalena P. Cardelo Marya Shanabrough Binod Aryal Rafael de Cabo Yajaira Suárez Tamas L. Horvath Carlos Fernández-Hernando |
| author_facet | Nathan L. Price Pablo Fernández-Tussy Luis Varela Magdalena P. Cardelo Marya Shanabrough Binod Aryal Rafael de Cabo Yajaira Suárez Tamas L. Horvath Carlos Fernández-Hernando |
| author_sort | Nathan L. Price |
| collection | DOAJ |
| description | Abstract AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established, the role of microRNAs in this process is poorly understood. Utilizing unique mouse models, we demonstrate that miR-33 plays a critical role in the regulation of AgRP neurons, and that loss of miR-33 leads to increased feeding, obesity, and metabolic dysfunction in mice. These effects include the regulation of multiple miR-33 target genes involved in mitochondrial biogenesis and fatty acid metabolism. Our findings elucidate a key regulatory pathway regulated by a non-coding RNA that impacts hunger by controlling multiple bioenergetic processes associated with the activation of AgRP neurons, providing alternative therapeutic approaches to modulate feeding behavior and associated metabolic diseases. |
| first_indexed | 2024-04-25T01:05:26Z |
| format | Article |
| id | doaj.art-f1a854edd40041bf8676f1f698ab6e77 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-25T01:05:26Z |
| publishDate | 2024-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f1a854edd40041bf8676f1f698ab6e772024-03-10T12:16:30ZengNature PortfolioNature Communications2041-17232024-03-0115111310.1038/s41467-024-46427-0microRNA-33 controls hunger signaling in hypothalamic AgRP neuronsNathan L. Price0Pablo Fernández-Tussy1Luis Varela2Magdalena P. Cardelo3Marya Shanabrough4Binod Aryal5Rafael de Cabo6Yajaira Suárez7Tamas L. Horvath8Carlos Fernández-Hernando9Vascular Biology and Therapeutics Program, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineDepartment of Comparative Medicine, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineDepartment of Comparative Medicine, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineExperimental Gerontology Section, Translational Gerontology Branch, National Institute on Aging, National Institutes of HealthVascular Biology and Therapeutics Program, Yale University School of MedicineDepartment of Comparative Medicine, Yale University School of MedicineVascular Biology and Therapeutics Program, Yale University School of MedicineAbstract AgRP neurons drive hunger, and excessive nutrient intake is the primary driver of obesity and associated metabolic disorders. While many factors impacting central regulation of feeding behavior have been established, the role of microRNAs in this process is poorly understood. Utilizing unique mouse models, we demonstrate that miR-33 plays a critical role in the regulation of AgRP neurons, and that loss of miR-33 leads to increased feeding, obesity, and metabolic dysfunction in mice. These effects include the regulation of multiple miR-33 target genes involved in mitochondrial biogenesis and fatty acid metabolism. Our findings elucidate a key regulatory pathway regulated by a non-coding RNA that impacts hunger by controlling multiple bioenergetic processes associated with the activation of AgRP neurons, providing alternative therapeutic approaches to modulate feeding behavior and associated metabolic diseases.https://doi.org/10.1038/s41467-024-46427-0 |
| spellingShingle | Nathan L. Price Pablo Fernández-Tussy Luis Varela Magdalena P. Cardelo Marya Shanabrough Binod Aryal Rafael de Cabo Yajaira Suárez Tamas L. Horvath Carlos Fernández-Hernando microRNA-33 controls hunger signaling in hypothalamic AgRP neurons Nature Communications |
| title | microRNA-33 controls hunger signaling in hypothalamic AgRP neurons |
| title_full | microRNA-33 controls hunger signaling in hypothalamic AgRP neurons |
| title_fullStr | microRNA-33 controls hunger signaling in hypothalamic AgRP neurons |
| title_full_unstemmed | microRNA-33 controls hunger signaling in hypothalamic AgRP neurons |
| title_short | microRNA-33 controls hunger signaling in hypothalamic AgRP neurons |
| title_sort | microrna 33 controls hunger signaling in hypothalamic agrp neurons |
| url | https://doi.org/10.1038/s41467-024-46427-0 |
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