Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation
Introduction: Major depressive disorder (MDD) is a leading global psychiatric disease. MDD is highly comorbid with gastrointestinal abnormalities, such as gut motility dysfunction. An effective strategy to manage depression and its accompanying gastrointestinal symptoms is warranted. Objectives: Thr...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Journal of Advanced Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090123222001151 |
| _version_ | 1797894433059897344 |
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| author | Peijun Tian Renying Zou Luyao Wang Ying Chen Xin Qian Jianxin Zhao Hao Zhang Long Qian Qun Wang Gang Wang Wei Chen |
| author_facet | Peijun Tian Renying Zou Luyao Wang Ying Chen Xin Qian Jianxin Zhao Hao Zhang Long Qian Qun Wang Gang Wang Wei Chen |
| author_sort | Peijun Tian |
| collection | DOAJ |
| description | Introduction: Major depressive disorder (MDD) is a leading global psychiatric disease. MDD is highly comorbid with gastrointestinal abnormalities, such as gut motility dysfunction. An effective strategy to manage depression and its accompanying gastrointestinal symptoms is warranted. Objectives: Three probiotic strains (Bifidobacterium breve CCFM1025, Bifidobacterium longum CCFM687, and Pediococcus acidilactici CCFM6432) had previously been validated in mice to possess antidepressant-like potential. This study investigated the potential psychotropic effects of a combined three-strain probiotic intervention for human MDD patients. The mechanism of action was further investigated in the stress-induced depression mice model. Methods: MDD patients were given a freeze-dried, mixed probiotic formula for four weeks. The patients’ psychometric and gastrointestinal conditions were evaluated using clinical rating scales before and after treatment. Their gut microbiome was also analysed using 16S rRNA gene amplicon sequencing. The mechanisms underlying the beneficial probiotic effects were determined using a chronic stress-induced depressive mouse model. Results: Multi-probiotics significantly reduced depression scores, and to a greater extent than the placebo (based on the Hamilton Depression Rating, Montgomery-Asberg Depression Rating, and Brief Psychiatric Rating Scales). Multi-probiotics also significantly improved the patients’ gastrointestinal functions (based on self-evaluation using the Gastrointestinal Symptom Rating Scale). Serotonergic system modification was demonstrated as the key mechanism behind the probiotics’ benefits for the brain and the gut. Conclusion: Our findings suggest a novel and promising treatment to manage MDD and accompanying gut motility problems, and provide options for treating other gut-brain axis-related disorders. |
| first_indexed | 2024-04-10T07:08:58Z |
| format | Article |
| id | doaj.art-f1a8fa02a70c458ab9fbb8187725c6ae |
| institution | Directory Open Access Journal |
| issn | 2090-1232 |
| language | English |
| last_indexed | 2024-04-10T07:08:58Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Advanced Research |
| spelling | doaj.art-f1a8fa02a70c458ab9fbb8187725c6ae2023-02-27T04:07:03ZengElsevierJournal of Advanced Research2090-12322023-03-0145117125Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulationPeijun Tian0Renying Zou1Luyao Wang2Ying Chen3Xin Qian4Jianxin Zhao5Hao Zhang6Long Qian7Qun Wang8Gang Wang9Wei Chen10State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, ChinaThe Tinghu People’s Hospital, Yancheng 224002, ChinaThe Tinghu People’s Hospital, Yancheng 224002, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China; Corresponding author at: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China.State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, ChinaIntroduction: Major depressive disorder (MDD) is a leading global psychiatric disease. MDD is highly comorbid with gastrointestinal abnormalities, such as gut motility dysfunction. An effective strategy to manage depression and its accompanying gastrointestinal symptoms is warranted. Objectives: Three probiotic strains (Bifidobacterium breve CCFM1025, Bifidobacterium longum CCFM687, and Pediococcus acidilactici CCFM6432) had previously been validated in mice to possess antidepressant-like potential. This study investigated the potential psychotropic effects of a combined three-strain probiotic intervention for human MDD patients. The mechanism of action was further investigated in the stress-induced depression mice model. Methods: MDD patients were given a freeze-dried, mixed probiotic formula for four weeks. The patients’ psychometric and gastrointestinal conditions were evaluated using clinical rating scales before and after treatment. Their gut microbiome was also analysed using 16S rRNA gene amplicon sequencing. The mechanisms underlying the beneficial probiotic effects were determined using a chronic stress-induced depressive mouse model. Results: Multi-probiotics significantly reduced depression scores, and to a greater extent than the placebo (based on the Hamilton Depression Rating, Montgomery-Asberg Depression Rating, and Brief Psychiatric Rating Scales). Multi-probiotics also significantly improved the patients’ gastrointestinal functions (based on self-evaluation using the Gastrointestinal Symptom Rating Scale). Serotonergic system modification was demonstrated as the key mechanism behind the probiotics’ benefits for the brain and the gut. Conclusion: Our findings suggest a novel and promising treatment to manage MDD and accompanying gut motility problems, and provide options for treating other gut-brain axis-related disorders.http://www.sciencedirect.com/science/article/pii/S2090123222001151DepressionGut motilityProbioticsSerotoninStress |
| spellingShingle | Peijun Tian Renying Zou Luyao Wang Ying Chen Xin Qian Jianxin Zhao Hao Zhang Long Qian Qun Wang Gang Wang Wei Chen Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation Journal of Advanced Research Depression Gut motility Probiotics Serotonin Stress |
| title | Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation |
| title_full | Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation |
| title_fullStr | Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation |
| title_full_unstemmed | Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation |
| title_short | Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation |
| title_sort | multi probiotics ameliorate major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation |
| topic | Depression Gut motility Probiotics Serotonin Stress |
| url | http://www.sciencedirect.com/science/article/pii/S2090123222001151 |
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