Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy
The characteristic features of neurotrophic keratopathy have been well documented by in vivo and in vitro studies using animal models. However, case reports of neurotrophic keratopathy induced by neurosurgery are limited. We describe the clinical characteristics, anterior segment optical coherence t...
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MDPI AG
2022-06-01
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| Series: | Journal of Clinical Medicine |
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| author | Shimpei Oba Kaoru Araki-Sasaki Tomoyuki Chihara Takashi Kojima Dogru Murat Kanji Takahashi |
| author_facet | Shimpei Oba Kaoru Araki-Sasaki Tomoyuki Chihara Takashi Kojima Dogru Murat Kanji Takahashi |
| author_sort | Shimpei Oba |
| collection | DOAJ |
| description | The characteristic features of neurotrophic keratopathy have been well documented by in vivo and in vitro studies using animal models. However, case reports of neurotrophic keratopathy induced by neurosurgery are limited. We describe the clinical characteristics, anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) findings of neurotrophic keratopathy induced by surgery for intracranial lesions. This is a case series including 6 eyes of 3 patients (mean age, 69.67 ± 12.50 years) with unilateral neurotrophic keratopathy. The clinical findings of three patients were described and IVCM findings of three patients were analyzed. The duration of neuropathy ranged from 2 to 30 years (median, 22 years). Thickening of the epithelial layer and higher reflection density of the anterior stroma were observed during the healing process using AS-OCT. The mean nerve fiber density of the subepithelial plexus, as determined by IVCM, was 1943 ± 1000 μm/mm<sup>2</sup> for neurotrophic eyes and 2242 ± 600.3 μm/mm<sup>2</sup> for contralateral eyes (<i>p</i> = 0.0347). The mean respective dendritic cell densities were 30.8 ± 21.8 and 6.25 ± 5.59 cells/mm<sup>2</sup> (<i>p</i> < 0.0001), while the mean basal cell sizes were 259 ± 86.5 and 185 ± 45.9 μm<sup>2</sup> (<i>p</i> < 0.0001), respectively. These findings suggest that neurosurgery-induced neurotrophic keratopathy may be associated with alterations in the healing process and immune cell distribution in the cornea. |
| first_indexed | 2024-03-09T10:27:43Z |
| format | Article |
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| language | English |
| last_indexed | 2024-03-09T10:27:43Z |
| publishDate | 2022-06-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-f1a979195e254106a1dc25120e42cba12023-12-01T21:32:58ZengMDPI AGJournal of Clinical Medicine2077-03832022-06-011113380410.3390/jcm11133804Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic KeratopathyShimpei Oba0Kaoru Araki-Sasaki1Tomoyuki Chihara2Takashi Kojima3Dogru Murat4Kanji Takahashi5Department of Ophthalmology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, JapanDepartment of Ophthalmology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, JapanDepartment of Ophthalmology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, JapanDepartment of Ophthalmology, Keio University School of Medicine, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, JapanDepartment of Ophthalmology, Keio University School of Medicine, 2-15-45 Mita, Minato-ku, Tokyo 108-8345, JapanDepartment of Ophthalmology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 573-1010, JapanThe characteristic features of neurotrophic keratopathy have been well documented by in vivo and in vitro studies using animal models. However, case reports of neurotrophic keratopathy induced by neurosurgery are limited. We describe the clinical characteristics, anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscopy (IVCM) findings of neurotrophic keratopathy induced by surgery for intracranial lesions. This is a case series including 6 eyes of 3 patients (mean age, 69.67 ± 12.50 years) with unilateral neurotrophic keratopathy. The clinical findings of three patients were described and IVCM findings of three patients were analyzed. The duration of neuropathy ranged from 2 to 30 years (median, 22 years). Thickening of the epithelial layer and higher reflection density of the anterior stroma were observed during the healing process using AS-OCT. The mean nerve fiber density of the subepithelial plexus, as determined by IVCM, was 1943 ± 1000 μm/mm<sup>2</sup> for neurotrophic eyes and 2242 ± 600.3 μm/mm<sup>2</sup> for contralateral eyes (<i>p</i> = 0.0347). The mean respective dendritic cell densities were 30.8 ± 21.8 and 6.25 ± 5.59 cells/mm<sup>2</sup> (<i>p</i> < 0.0001), while the mean basal cell sizes were 259 ± 86.5 and 185 ± 45.9 μm<sup>2</sup> (<i>p</i> < 0.0001), respectively. These findings suggest that neurosurgery-induced neurotrophic keratopathy may be associated with alterations in the healing process and immune cell distribution in the cornea.https://www.mdpi.com/2077-0383/11/13/3804neurotrophic keratopathytrigeminal nervecorneal basal cellsdendritic cells Schirmer test |
| spellingShingle | Shimpei Oba Kaoru Araki-Sasaki Tomoyuki Chihara Takashi Kojima Dogru Murat Kanji Takahashi Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy Journal of Clinical Medicine neurotrophic keratopathy trigeminal nerve corneal basal cells dendritic cells Schirmer test |
| title | Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy |
| title_full | Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy |
| title_fullStr | Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy |
| title_full_unstemmed | Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy |
| title_short | Aberrant Corneal Homeostasis in Neurosurgery-Induced Neurotrophic Keratopathy |
| title_sort | aberrant corneal homeostasis in neurosurgery induced neurotrophic keratopathy |
| topic | neurotrophic keratopathy trigeminal nerve corneal basal cells dendritic cells Schirmer test |
| url | https://www.mdpi.com/2077-0383/11/13/3804 |
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