Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal study
OBJECTIVES: The aim was to prospectively assess the variation in liver stiffness (LS) and the associated factors for LS progression in a cohort of naïve, non-responder (NR), and sustained virological response (SVR) chronic hepatitis C (CHC) patients. METHODS: This was a longitudinal study on CHC pa...
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| Format: | Article |
| Language: | English |
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Elsevier España
2021-11-01
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| Series: | Clinics |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100327&tlng=en |
| _version_ | 1811229575439450112 |
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| author | Daniela Malta Pontual Leticia Cancella Nabuco Ronir Raggio Luiz Ana Carolina Cardoso Renata M. Perez Cristiane A. Villela-Nogueira |
| author_facet | Daniela Malta Pontual Leticia Cancella Nabuco Ronir Raggio Luiz Ana Carolina Cardoso Renata M. Perez Cristiane A. Villela-Nogueira |
| author_sort | Daniela Malta Pontual |
| collection | DOAJ |
| description | OBJECTIVES: The aim was to prospectively assess the variation in liver stiffness (LS) and the associated factors for LS progression in a cohort of naïve, non-responder (NR), and sustained virological response (SVR) chronic hepatitis C (CHC) patients. METHODS: This was a longitudinal study on CHC patients prospectively followed with serial elastography (Fibroscan®). The LS progression rate was determined, and the associated factors for progression were assessed using multiple linear regression analysis. RESULTS: A total of 406 patients were followed up for 44 (35-53) months [naïve (29%), NR (24%), and SVR (47%)]. At the end of the follow-up period, the SVR group had a significant decrease in LS [11.8 (9.2) vs. 8.8 (8.4) kPa (p<0.001)], the NR group had a significant increase in LS [6.6 (5.2) vs. 7.1 (4.5) kPa (p=0.069)], and the naïve group had no change in LS [6.3 (3.0) vs. 6.0 (3.8) kPa (p=0.22)]. The related factors for LS progression were lack of SVR (p=0.002) and diabetes (p=0.05). In the non-diabetic SVR group, a negative rate of progression (-0.047 kPa/month) was observed, whereas in the diabetic SVR group, a positive rate of progression (+0.037 kPa/month) was observed. The highest rate of progression was observed in NR with diabetes at the rate of +0.044 kPa/month. CONCLUSION: LS in diabetes patients progresses despite SVR, suggesting the need for a close follow-up of this group post-treatment considering the risk of progression of liver disease even after SVR. |
| first_indexed | 2024-04-12T10:16:28Z |
| format | Article |
| id | doaj.art-f1abf22bf70042c995606d4fbf208b01 |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-04-12T10:16:28Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-f1abf22bf70042c995606d4fbf208b012022-12-22T03:37:11ZengElsevier EspañaClinics1980-53222021-11-017610.6061/clinics/2021/e3236Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal studyDaniela Malta Pontualhttps://orcid.org/0000-0003-1740-1233Leticia Cancella Nabucohttps://orcid.org/0000-0002-7340-4650Ronir Raggio Luizhttps://orcid.org/0000-0002-7784-9905Ana Carolina Cardosohttps://orcid.org/0000-0002-4552-8453Renata M. Perezhttps://orcid.org/0000-0002-3367-9991Cristiane A. Villela-Nogueirahttps://orcid.org/0000-0003-1355-2368OBJECTIVES: The aim was to prospectively assess the variation in liver stiffness (LS) and the associated factors for LS progression in a cohort of naïve, non-responder (NR), and sustained virological response (SVR) chronic hepatitis C (CHC) patients. METHODS: This was a longitudinal study on CHC patients prospectively followed with serial elastography (Fibroscan®). The LS progression rate was determined, and the associated factors for progression were assessed using multiple linear regression analysis. RESULTS: A total of 406 patients were followed up for 44 (35-53) months [naïve (29%), NR (24%), and SVR (47%)]. At the end of the follow-up period, the SVR group had a significant decrease in LS [11.8 (9.2) vs. 8.8 (8.4) kPa (p<0.001)], the NR group had a significant increase in LS [6.6 (5.2) vs. 7.1 (4.5) kPa (p=0.069)], and the naïve group had no change in LS [6.3 (3.0) vs. 6.0 (3.8) kPa (p=0.22)]. The related factors for LS progression were lack of SVR (p=0.002) and diabetes (p=0.05). In the non-diabetic SVR group, a negative rate of progression (-0.047 kPa/month) was observed, whereas in the diabetic SVR group, a positive rate of progression (+0.037 kPa/month) was observed. The highest rate of progression was observed in NR with diabetes at the rate of +0.044 kPa/month. CONCLUSION: LS in diabetes patients progresses despite SVR, suggesting the need for a close follow-up of this group post-treatment considering the risk of progression of liver disease even after SVR.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100327&tlng=enChronic Hepatitis CElastographySustained Virological ResponseDiabetes Mellitus |
| spellingShingle | Daniela Malta Pontual Leticia Cancella Nabuco Ronir Raggio Luiz Ana Carolina Cardoso Renata M. Perez Cristiane A. Villela-Nogueira Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal study Clinics Chronic Hepatitis C Elastography Sustained Virological Response Diabetes Mellitus |
| title | Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal study |
| title_full | Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal study |
| title_fullStr | Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal study |
| title_full_unstemmed | Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal study |
| title_short | Diabetes influences liver stiffness in chronic hepatitis C patients with and without virological cure: A longitudinal study |
| title_sort | diabetes influences liver stiffness in chronic hepatitis c patients with and without virological cure a longitudinal study |
| topic | Chronic Hepatitis C Elastography Sustained Virological Response Diabetes Mellitus |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322021000100327&tlng=en |
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