A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infection
ObjectiveGram-negative bacilli (GNB) are common pathogens of infection in severe acute pancreatitis (SAP), and their occurrence increases the mortality of SAP. Early identification of SAP severity and prognosis is of great significance to SAP treatment. This study explored risk factors for mortality...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1032375/full |
| _version_ | 1817975328940752896 |
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| author | Jia Yan Huang Yilin Wu Di Wang Jie Wang Hanyue Liu Ya Peng Jie |
| author_facet | Jia Yan Huang Yilin Wu Di Wang Jie Wang Hanyue Liu Ya Peng Jie |
| author_sort | Jia Yan |
| collection | DOAJ |
| description | ObjectiveGram-negative bacilli (GNB) are common pathogens of infection in severe acute pancreatitis (SAP), and their occurrence increases the mortality of SAP. Early identification of SAP severity and prognosis is of great significance to SAP treatment. This study explored risk factors for mortality in patients with SAP and GNB infection and established a model for early prediction of the risk of death in GNB-infected SAP patients.MethodsPatients diagnosed with SAP from January 1, 2016, to March 31, 2022, were included, and their baseline clinical characteristics were collected. Univariate logistic regression analysis was performed to screen for death related variables, and concurrently, a Boruta analysis was performed to identify potentially important clinical features associated with mortality. The intersection of the two results was taken for further multivariate logistic regression analysis. A logistic regression model was constructed according to the independent risk factor of death and then visualized with a nomogram. The performance of the model was further validated in the training and validation cohort.ResultsA total of 151 patients with SAP developed GNB infections. Univariate logistic regression analysis identified 11 variables associated with mortality. The Boruta analysis identified 11 clinical features, and 4 out of 9 clinical variables: platelet counts (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.99–1.00; p = 0.007), hemoglobin (OR 0.96, 95% CI 0.92–1; p = 0.037), septic shock (OR 6.33, 95% CI 1.12–43.47; p = 0.044), and carbapenem resistance (OR 7.99, 95% CI 1.66–52.37; p = 0.016), shared by both analyses were further selected as independent risk factors by multivariate logistic regression analysis. A nomogram was used to visualize the model. The model demonstrated good performance in both training and validation cohorts with recognition sensitivity and specificity of 96% and 80% in the training cohort and 92.8% and 75% in the validation cohort, respectively.ConclusionThe nomogram can accurately predict the mortality risk of patients with SAP and GNB infection. The clinical application of this model allows early identification of the severity and prognosis for patients with SAP and GNB infection and identification of patients requiring urgent management thus allowing rationalization of treatment options and improvements in clinical outcomes. |
| first_indexed | 2024-04-13T21:47:41Z |
| format | Article |
| id | doaj.art-f1ac48c6a62a4ddbbe75fb4da15d2055 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-13T21:47:41Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-f1ac48c6a62a4ddbbe75fb4da15d20552022-12-22T02:28:31ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-11-011210.3389/fcimb.2022.10323751032375A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infectionJia YanHuang YilinWu DiWang JieWang HanyueLiu YaPeng JieObjectiveGram-negative bacilli (GNB) are common pathogens of infection in severe acute pancreatitis (SAP), and their occurrence increases the mortality of SAP. Early identification of SAP severity and prognosis is of great significance to SAP treatment. This study explored risk factors for mortality in patients with SAP and GNB infection and established a model for early prediction of the risk of death in GNB-infected SAP patients.MethodsPatients diagnosed with SAP from January 1, 2016, to March 31, 2022, were included, and their baseline clinical characteristics were collected. Univariate logistic regression analysis was performed to screen for death related variables, and concurrently, a Boruta analysis was performed to identify potentially important clinical features associated with mortality. The intersection of the two results was taken for further multivariate logistic regression analysis. A logistic regression model was constructed according to the independent risk factor of death and then visualized with a nomogram. The performance of the model was further validated in the training and validation cohort.ResultsA total of 151 patients with SAP developed GNB infections. Univariate logistic regression analysis identified 11 variables associated with mortality. The Boruta analysis identified 11 clinical features, and 4 out of 9 clinical variables: platelet counts (odds ratio [OR] 0.99, 95% confidence interval [CI] 0.99–1.00; p = 0.007), hemoglobin (OR 0.96, 95% CI 0.92–1; p = 0.037), septic shock (OR 6.33, 95% CI 1.12–43.47; p = 0.044), and carbapenem resistance (OR 7.99, 95% CI 1.66–52.37; p = 0.016), shared by both analyses were further selected as independent risk factors by multivariate logistic regression analysis. A nomogram was used to visualize the model. The model demonstrated good performance in both training and validation cohorts with recognition sensitivity and specificity of 96% and 80% in the training cohort and 92.8% and 75% in the validation cohort, respectively.ConclusionThe nomogram can accurately predict the mortality risk of patients with SAP and GNB infection. The clinical application of this model allows early identification of the severity and prognosis for patients with SAP and GNB infection and identification of patients requiring urgent management thus allowing rationalization of treatment options and improvements in clinical outcomes.https://www.frontiersin.org/articles/10.3389/fcimb.2022.1032375/fullsevere acute pancreatitiscarbapenem-resistant Gram-negative bacilliseptic shockpredictive modelnomogram |
| spellingShingle | Jia Yan Huang Yilin Wu Di Wang Jie Wang Hanyue Liu Ya Peng Jie A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infection Frontiers in Cellular and Infection Microbiology severe acute pancreatitis carbapenem-resistant Gram-negative bacilli septic shock predictive model nomogram |
| title | A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infection |
| title_full | A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infection |
| title_fullStr | A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infection |
| title_full_unstemmed | A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infection |
| title_short | A nomogram for predicting the risk of mortality in patients with acute pancreatitis and Gram-negative bacilli infection |
| title_sort | nomogram for predicting the risk of mortality in patients with acute pancreatitis and gram negative bacilli infection |
| topic | severe acute pancreatitis carbapenem-resistant Gram-negative bacilli septic shock predictive model nomogram |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.1032375/full |
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