Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles
In order to maintain a stable cone-jet mode in electrospray low flow rates are used while most applications require a high throughput. We compare two different designs of the multiple electrospray system in order to increase the output for large scale production applications. In this study, the solu...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2017-07-01
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| Series: | Materials & Design |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127517303854 |
| _version_ | 1819042783533465600 |
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| author | M. Parhizkar P.J.T. Reardon J.C. Knowles R.J. Browning E. Stride R.B. Pedley T. Grego M. Edirisinghe |
| author_facet | M. Parhizkar P.J.T. Reardon J.C. Knowles R.J. Browning E. Stride R.B. Pedley T. Grego M. Edirisinghe |
| author_sort | M. Parhizkar |
| collection | DOAJ |
| description | In order to maintain a stable cone-jet mode in electrospray low flow rates are used while most applications require a high throughput. We compare two different designs of the multiple electrospray system in order to increase the output for large scale production applications. In this study, the solution was fed through four separate needles that were attached to either a circular or a rectangular metallic plate that were connected to a high voltage DC power supply. The behaviour of the electrospray jets as well as the deposition of particles were investigated. It was shown that the throughput of particles was increased while particles with narrow size distribution were produced from all four uniform electrospray jets. Keywords: Electrohydrodynamic, Electrospray, Multiplexing electrospray, Particles, Polymer, Carriers, Drug delivery |
| first_indexed | 2024-12-21T09:46:23Z |
| format | Article |
| id | doaj.art-f1acc616d1294be184995a9c969c70a0 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-21T09:46:23Z |
| publishDate | 2017-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-f1acc616d1294be184995a9c969c70a02022-12-21T19:08:19ZengElsevierMaterials & Design0264-12752017-07-011267384Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticlesM. Parhizkar0P.J.T. Reardon1J.C. Knowles2R.J. Browning3E. Stride4R.B. Pedley5T. Grego6M. Edirisinghe7Department of Mechanical Engineering, University College London, London, UKDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UKDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UKInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UKInstitute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, UKUCL Cancer Institute, Department of Oncology, University College London, London, UKDepartment of Mechanical Engineering, University College London, London, UKDepartment of Mechanical Engineering, University College London, London, UK; Corresponding author.In order to maintain a stable cone-jet mode in electrospray low flow rates are used while most applications require a high throughput. We compare two different designs of the multiple electrospray system in order to increase the output for large scale production applications. In this study, the solution was fed through four separate needles that were attached to either a circular or a rectangular metallic plate that were connected to a high voltage DC power supply. The behaviour of the electrospray jets as well as the deposition of particles were investigated. It was shown that the throughput of particles was increased while particles with narrow size distribution were produced from all four uniform electrospray jets. Keywords: Electrohydrodynamic, Electrospray, Multiplexing electrospray, Particles, Polymer, Carriers, Drug deliveryhttp://www.sciencedirect.com/science/article/pii/S0264127517303854 |
| spellingShingle | M. Parhizkar P.J.T. Reardon J.C. Knowles R.J. Browning E. Stride R.B. Pedley T. Grego M. Edirisinghe Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles Materials & Design |
| title | Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles |
| title_full | Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles |
| title_fullStr | Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles |
| title_full_unstemmed | Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles |
| title_short | Performance of novel high throughput multi electrospray systems for forming of polymeric micro/nanoparticles |
| title_sort | performance of novel high throughput multi electrospray systems for forming of polymeric micro nanoparticles |
| url | http://www.sciencedirect.com/science/article/pii/S0264127517303854 |
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