Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation
We established an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome, carrying heterozygous c.290 + 1G > A mutation in STK11 gene. Peripheral blood mononuclear cells were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expressed plu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123001381 |
| _version_ | 1797692088342544384 |
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| author | Teng Wang Kongxi Zhu Weihua Yu Lei Peng Hongjuan Wang Qiong Wu |
| author_facet | Teng Wang Kongxi Zhu Weihua Yu Lei Peng Hongjuan Wang Qiong Wu |
| author_sort | Teng Wang |
| collection | DOAJ |
| description | We established an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome, carrying heterozygous c.290 + 1G > A mutation in STK11 gene. Peripheral blood mononuclear cells were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expressed pluripotency markers, could differentiate into cells of three germ layers in vitro, and displayed a normal karyotype. |
| first_indexed | 2024-03-12T02:22:40Z |
| format | Article |
| id | doaj.art-f1af59bbb6b046b6bfd00ad78ed7038e |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-12T02:22:40Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-f1af59bbb6b046b6bfd00ad78ed7038e2023-09-06T04:50:47ZengElsevierStem Cell Research1873-50612023-09-0171103152Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutationTeng Wang0Kongxi Zhu1Weihua Yu2Lei Peng3Hongjuan Wang4Qiong Wu5Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, ChinaDepartment of Gastroenterology, The Second Hospital of Shandong University, Jinan, ChinaDepartment of Gastroenterology, The Second Hospital of Shandong University, Jinan, ChinaDepartment of Gastroenterology, The Second Hospital of Shandong University, Jinan, ChinaDepartment of Gastroenterology, The Second Hospital of Shandong University, Jinan, ChinaCorresponding author.; Department of Gastroenterology, The Second Hospital of Shandong University, Jinan, ChinaWe established an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome, carrying heterozygous c.290 + 1G > A mutation in STK11 gene. Peripheral blood mononuclear cells were reprogrammed using non-integrating delivery of OCT4, SOX2, KFL4, BCL-XL and c-MYC. The iPSC line expressed pluripotency markers, could differentiate into cells of three germ layers in vitro, and displayed a normal karyotype.http://www.sciencedirect.com/science/article/pii/S1873506123001381 |
| spellingShingle | Teng Wang Kongxi Zhu Weihua Yu Lei Peng Hongjuan Wang Qiong Wu Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation Stem Cell Research |
| title | Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation |
| title_full | Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation |
| title_fullStr | Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation |
| title_full_unstemmed | Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation |
| title_short | Generation of an iPSC line (TSHSUi001-A) from a patient with Peutz-Jeghers syndrome due to STK11 mutation |
| title_sort | generation of an ipsc line tshsui001 a from a patient with peutz jeghers syndrome due to stk11 mutation |
| url | http://www.sciencedirect.com/science/article/pii/S1873506123001381 |
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