Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy
BackgroundWe investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. Methods and ResultsThis study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied assoc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-12-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.117.006750 |
| _version_ | 1811332301525614592 |
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| author | Pavla Cermakova Majon Muller Anderson C. Armstrong Dorota Religa R. Nick Bryan João A. C. Lima Lenore J. Launer |
| author_facet | Pavla Cermakova Majon Muller Anderson C. Armstrong Dorota Religa R. Nick Bryan João A. C. Lima Lenore J. Launer |
| author_sort | Pavla Cermakova |
| collection | DOAJ |
| description | BackgroundWe investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. Methods and ResultsThis study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (β=−0.002; P <0.02). The association was strongest in black participants and in men. ConclusionsHigher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men. |
| first_indexed | 2024-04-13T16:33:50Z |
| format | Article |
| id | doaj.art-f1b06a860ba64591a70a515f93b25f58 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:33:50Z |
| publishDate | 2017-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-f1b06a860ba64591a70a515f93b25f582022-12-22T02:39:29ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802017-12-0161210.1161/JAHA.117.006750Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging SubstudyPavla Cermakova0Majon Muller1Anderson C. Armstrong2Dorota Religa3R. Nick Bryan4João A. C. Lima5Lenore J. Launer6Division for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, SwedenLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MDDivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MDDivision for Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Stockholm, SwedenDepartment of Radiology, University of Pennsylvania, Philadelphia, PADivision of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MDLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MDBackgroundWe investigated whether cardiac parameters in young adulthood are associated with indicators of brain health in midlife. Methods and ResultsThis study includes 648 participants from the CARDIA (Coronary Artery Risk Development in Young Adults) study (52% women, 38% black). We studied associations of cardiac parameters assessed by echocardiography (left ventricular ejection fraction, left atrial volume, and left ventricular mass) in young adulthood (mean age: 30 years) with brain measures obtained by magnetic resonance imaging (total brain, gray and white matter volume, white matter integrity, abnormal white matter) in midlife (mean age: 50 years). In 406 individuals with complete measurements, higher left atrial volume was associated with lower white matter fractional anisotropy, independent of traditional cardiovascular risk factors (β=−0.002; P <0.02). The association was strongest in black participants and in men. ConclusionsHigher left atrial volume in early adulthood is associated with impairment of white matter integrity in midlife. Interventions to improve cardiac function in young adults may benefit brain health and should be targeted in particular at black men.https://www.ahajournals.org/doi/10.1161/JAHA.117.006750brainechocardiographyepidemiologymagnetic resonance imagingwhite matteryoung adulthood |
| spellingShingle | Pavla Cermakova Majon Muller Anderson C. Armstrong Dorota Religa R. Nick Bryan João A. C. Lima Lenore J. Launer Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease brain echocardiography epidemiology magnetic resonance imaging white matter young adulthood |
| title | Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy |
| title_full | Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy |
| title_fullStr | Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy |
| title_full_unstemmed | Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy |
| title_short | Subclinical Cardiac Dysfunction and Brain Health in Midlife: CARDIA (Coronary Artery Risk Development in Young Adults) Brain Magnetic Resonance Imaging Substudy |
| title_sort | subclinical cardiac dysfunction and brain health in midlife cardia coronary artery risk development in young adults brain magnetic resonance imaging substudy |
| topic | brain echocardiography epidemiology magnetic resonance imaging white matter young adulthood |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.117.006750 |
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