Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study
Abstract Background Triglyceride-glucose (TyG) index is an efficient indicator of insulin resistance and is proven to be a valuable marker in several cardiovascular diseases. However, the relationship between TyG index and cardiac arrest (CA) remains unclear. The present study aimed to investigate t...
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-01918-0 |
| _version_ | 1827890632640692224 |
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| author | Yang Boshen Zhu Yuankang Zheng Xinjie Li Taixi Niu kaifan Wang Zhixiang Song Juan Duan Junli Li Suiji Lu Xia Shen Chengxing |
| author_facet | Yang Boshen Zhu Yuankang Zheng Xinjie Li Taixi Niu kaifan Wang Zhixiang Song Juan Duan Junli Li Suiji Lu Xia Shen Chengxing |
| author_sort | Yang Boshen |
| collection | DOAJ |
| description | Abstract Background Triglyceride-glucose (TyG) index is an efficient indicator of insulin resistance and is proven to be a valuable marker in several cardiovascular diseases. However, the relationship between TyG index and cardiac arrest (CA) remains unclear. The present study aimed to investigate the association of the TyG index with the occurrence and clinical outcomes of CA. Methods In this retrospective, multicenter, observational study, critically ill patients, including patients post-CA, were identified from the eICU Collaborative Research Database and evaluated. The TyG index for each patient was calculated using values of triglycerides and glucose recorded within 24 h of intensive care unit (ICU) admission. In-hospital mortality and ICU mortality were the primary clinical outcomes. Logistic regression, restricted cubic spline (RCS), and correlation analyses were performed to explore the relationship between the TyG index and clinical outcomes. Propensity score matching (PSM), overlap weighting (OW), and inverse probability of treatment weighting (IPTW) were adopted to balance the baseline characteristics of patients and minimize selection bias to confirm the robustness of the results. Subgroup analysis based on different modifiers was also performed. Results Overall, 24,689 critically ill patients, including 1021 patients post-CA, were enrolled. The TyG index was significantly higher in patients post-CA than in those without CA (9.20 (8.72–9.69) vs. 8.89 (8.45–9.41)), and the TyG index had a moderate discrimination ability to identify patients with CA from the overall population (area under the curve = 0.625). Multivariate logistic regression indicated that the TyG index was an independent risk factor for in-hospital mortality (OR = 1.28, 95% CI: 1.03–1.58) and ICU mortality (OR = 1.27, 95% CI: 1.02–1.58) in patients post-CA. RCS curves revealed that an increased TyG index was linearly related to higher risks of in-hospital and ICU mortality (P for nonlinear: 0.225 and 0.271, respectively). Even after adjusting by PSM, IPTW, and OW, the TyG index remained a risk factor for in-hospital mortality and ICU mortality in patients experiencing CA, which was independent of age, BMI, sex, etc. Correlation analyses revealed that TyG index was negatively correlated with the neurological status of patients post-CA. Conclusion Elevated TyG index is significantly associated with the occurrence of CA and higher mortality risk in patients post-CA. Our findings extend the landscape of TyG index in cardiovascular diseases, which requires further prospective cohort study. |
| first_indexed | 2024-03-12T21:12:28Z |
| format | Article |
| id | doaj.art-f1b12715653a4db9b4c9fcba4af14c0b |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-12T21:12:28Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-f1b12715653a4db9b4c9fcba4af14c0b2023-07-30T11:06:42ZengBMCCardiovascular Diabetology1475-28402023-07-0122111510.1186/s12933-023-01918-0Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational studyYang Boshen0Zhu Yuankang1Zheng Xinjie2Li Taixi3Niu kaifan4Wang Zhixiang5Song Juan6Duan Junli7Li Suiji8Lu Xia9Shen Chengxing10Department of Cardiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of MedicineInstitute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Respiratory Medicine, The Fourth Affiliated Hospital, College of Medicine, Zhejiang UniversityDepartment of Cardiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Cardiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Cardiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of MedicineXiamen Cardiovascular Hospital, Xiamen UniversityInstitute for Developmental and Regenerative Cardiovascular Medicine, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong UniversityXiamen Cardiovascular Hospital, Xiamen UniversityDepartment of Cardiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Cardiology, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University School of MedicineAbstract Background Triglyceride-glucose (TyG) index is an efficient indicator of insulin resistance and is proven to be a valuable marker in several cardiovascular diseases. However, the relationship between TyG index and cardiac arrest (CA) remains unclear. The present study aimed to investigate the association of the TyG index with the occurrence and clinical outcomes of CA. Methods In this retrospective, multicenter, observational study, critically ill patients, including patients post-CA, were identified from the eICU Collaborative Research Database and evaluated. The TyG index for each patient was calculated using values of triglycerides and glucose recorded within 24 h of intensive care unit (ICU) admission. In-hospital mortality and ICU mortality were the primary clinical outcomes. Logistic regression, restricted cubic spline (RCS), and correlation analyses were performed to explore the relationship between the TyG index and clinical outcomes. Propensity score matching (PSM), overlap weighting (OW), and inverse probability of treatment weighting (IPTW) were adopted to balance the baseline characteristics of patients and minimize selection bias to confirm the robustness of the results. Subgroup analysis based on different modifiers was also performed. Results Overall, 24,689 critically ill patients, including 1021 patients post-CA, were enrolled. The TyG index was significantly higher in patients post-CA than in those without CA (9.20 (8.72–9.69) vs. 8.89 (8.45–9.41)), and the TyG index had a moderate discrimination ability to identify patients with CA from the overall population (area under the curve = 0.625). Multivariate logistic regression indicated that the TyG index was an independent risk factor for in-hospital mortality (OR = 1.28, 95% CI: 1.03–1.58) and ICU mortality (OR = 1.27, 95% CI: 1.02–1.58) in patients post-CA. RCS curves revealed that an increased TyG index was linearly related to higher risks of in-hospital and ICU mortality (P for nonlinear: 0.225 and 0.271, respectively). Even after adjusting by PSM, IPTW, and OW, the TyG index remained a risk factor for in-hospital mortality and ICU mortality in patients experiencing CA, which was independent of age, BMI, sex, etc. Correlation analyses revealed that TyG index was negatively correlated with the neurological status of patients post-CA. Conclusion Elevated TyG index is significantly associated with the occurrence of CA and higher mortality risk in patients post-CA. Our findings extend the landscape of TyG index in cardiovascular diseases, which requires further prospective cohort study.https://doi.org/10.1186/s12933-023-01918-0TyG indexCardiac arrestIntensive care unitPrognosisHospital mortality |
| spellingShingle | Yang Boshen Zhu Yuankang Zheng Xinjie Li Taixi Niu kaifan Wang Zhixiang Song Juan Duan Junli Li Suiji Lu Xia Shen Chengxing Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study Cardiovascular Diabetology TyG index Cardiac arrest Intensive care unit Prognosis Hospital mortality |
| title | Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study |
| title_full | Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study |
| title_fullStr | Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study |
| title_full_unstemmed | Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study |
| title_short | Triglyceride-glucose index is associated with the occurrence and prognosis of cardiac arrest: a multicenter retrospective observational study |
| title_sort | triglyceride glucose index is associated with the occurrence and prognosis of cardiac arrest a multicenter retrospective observational study |
| topic | TyG index Cardiac arrest Intensive care unit Prognosis Hospital mortality |
| url | https://doi.org/10.1186/s12933-023-01918-0 |
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