A novel approach to the differential prognosis of early and late preeclampsia
In the present review, a new approach to studying the pathogenesis and predicting the development of preeclampsia (PE) – namely, the determination of matrix metalloproteinases (MMPs) – is discussed. Currently, the major cause of PE is thought to be an incomplete remodeling of spiral arteries because...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
IRBIS LLC
2018-08-01
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| Series: | Акушерство, гинекология и репродукция |
| Subjects: | |
| Online Access: | https://www.gynecology.su/jour/article/view/495 |
| _version_ | 1797884168833597440 |
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| author | A. N. Strizhakov Е. V. Timokhina S. M. Ibragimova V. S. Belousova Ya. O. Martirosyan |
| author_facet | A. N. Strizhakov Е. V. Timokhina S. M. Ibragimova V. S. Belousova Ya. O. Martirosyan |
| author_sort | A. N. Strizhakov |
| collection | DOAJ |
| description | In the present review, a new approach to studying the pathogenesis and predicting the development of preeclampsia (PE) – namely, the determination of matrix metalloproteinases (MMPs) – is discussed. Currently, the major cause of PE is thought to be an incomplete remodeling of spiral arteries because of an insufficient number of invading cytotrophoblasts or the absence/inactivation of crucial lysing enzymes, i.e. matrix metalloproteinases. The role of MMP-1, MМP-2, MМP-3, MМP-7, MМP-9 in the placenta formation, the development of oxidative stress and endothelial dysfunction is described. We propose that in the future, the MMPs may be used for differentially predicting early and late PE. |
| first_indexed | 2024-04-10T04:02:13Z |
| format | Article |
| id | doaj.art-f1b19db02475421f9c27092da636b2b8 |
| institution | Directory Open Access Journal |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| last_indexed | 2024-04-10T04:02:13Z |
| publishDate | 2018-08-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj.art-f1b19db02475421f9c27092da636b2b82023-03-13T07:09:49ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942018-08-01122556110.17749/2313-7347.2018.12.2.055-061457A novel approach to the differential prognosis of early and late preeclampsiaA. N. Strizhakov0Е. V. Timokhina1S. M. Ibragimova2V. S. Belousova3Ya. O. Martirosyan4I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian FederationI.M. Sechenov First Moscow State Medical University, Health Ministry of Russian FederationI.M. Sechenov First Moscow State Medical University, Health Ministry of Russian FederationI.M. Sechenov First Moscow State Medical University, Health Ministry of Russian FederationI.M. Sechenov First Moscow State Medical University, Health Ministry of Russian FederationIn the present review, a new approach to studying the pathogenesis and predicting the development of preeclampsia (PE) – namely, the determination of matrix metalloproteinases (MMPs) – is discussed. Currently, the major cause of PE is thought to be an incomplete remodeling of spiral arteries because of an insufficient number of invading cytotrophoblasts or the absence/inactivation of crucial lysing enzymes, i.e. matrix metalloproteinases. The role of MMP-1, MМP-2, MМP-3, MМP-7, MМP-9 in the placenta formation, the development of oxidative stress and endothelial dysfunction is described. We propose that in the future, the MMPs may be used for differentially predicting early and late PE.https://www.gynecology.su/jour/article/view/495matrix metalloproteinasesimplantationtrophoblastendothelial dysfunctionearly and late preeclampsia |
| spellingShingle | A. N. Strizhakov Е. V. Timokhina S. M. Ibragimova V. S. Belousova Ya. O. Martirosyan A novel approach to the differential prognosis of early and late preeclampsia Акушерство, гинекология и репродукция matrix metalloproteinases implantation trophoblast endothelial dysfunction early and late preeclampsia |
| title | A novel approach to the differential prognosis of early and late preeclampsia |
| title_full | A novel approach to the differential prognosis of early and late preeclampsia |
| title_fullStr | A novel approach to the differential prognosis of early and late preeclampsia |
| title_full_unstemmed | A novel approach to the differential prognosis of early and late preeclampsia |
| title_short | A novel approach to the differential prognosis of early and late preeclampsia |
| title_sort | novel approach to the differential prognosis of early and late preeclampsia |
| topic | matrix metalloproteinases implantation trophoblast endothelial dysfunction early and late preeclampsia |
| url | https://www.gynecology.su/jour/article/view/495 |
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