SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair

SETD8, a frequently mutated gene in cervical cancer, enhances cisplatin sensitivity by impairing DNA repair

Abstract Background Cisplatin is commonly used to treat cervical cancer while drug resistance limits its effectiveness. There is an urgent need to identify strategies that increase cisplatin sensitivity and improve the outcomes of chemotherapy. Results We performed whole exome sequencing (WES) of 15...

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Bibliographic Details
Main Authors: Xin Wang, Chen Cao, Xiangyu Tan, Xueyao Liao, Xiaofang Du, Xueqian Wang, Ting Liu, Danni Gong, Zheng Hu, Xun Tian
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Cell & Bioscience
Subjects:
Cisplatin sensitivity
SETD8
Cervical cancer
DNA repair
Whole exome sequencing
Online Access:https://doi.org/10.1186/s13578-023-01054-y

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