ANTIDEPRESSANT-LIKE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AGARICUS BLAZEI MURRILL IN STRESSED AND UNSTRESSED MICE
The objective of this study was to investigate the antidepressant activity of Agaricus blazei Murrill in stressed and unstressed swiss albino mice. Antidepressant activity was evaluated by consecutive oral administration of two doses i.e. (273 mg/kg and 819 mg/kg) of hydroalcoholic extract of Agaric...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2019-08-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/40803 |
| _version_ | 1818385592340185088 |
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| author | Israr ul Haq Muhammad Aslam Hammad Ahmed Nuzhat Sultana |
| author_facet | Israr ul Haq Muhammad Aslam Hammad Ahmed Nuzhat Sultana |
| author_sort | Israr ul Haq |
| collection | DOAJ |
| description | The objective of this study was to investigate the antidepressant activity of Agaricus blazei Murrill in stressed and unstressed swiss albino mice. Antidepressant activity was evaluated by consecutive oral administration of two doses i.e. (273 mg/kg and 819 mg/kg) of hydroalcoholic extract of Agaricus blazei Murrill. Mice were immobilized to induce stress. Fluoxetine 20 mg/kg orally was given to stressed and unstressed animals and immobility time was noted by using forced swim test and tail suspension test. The concentration of plasma nitrite was also evaluated in stressed and unstressed mice. The effect of prazosin (a1-adrenoceptor antagonist), p-CPA (parachlorophenylalanine – tryptophan hydroxylase inhibitor) and 7-nitroindazole (nNOS inhibitor) on the antidepressant activity of Agaricus blazei Murrill was also evaluated. Agaricus blazei Murrill (273 mg/kg, 819 mg/kg, and fluoxetine 20 mg/kg, p.o.) significantly decreased the duration of immobility time in stressed and unstressed mice, showing significant antidepressant activity. No substantial change was found in the locomotor activity. However, significant reduction in the level of plasma nitrite was also noted in stressed mice. Hydroalcoholic extract of Agaricus blazei Murrill showed prominent antidepressant activity in mice. |
| first_indexed | 2024-12-14T03:40:36Z |
| format | Article |
| id | doaj.art-f1b41588477840a2b617ed6a35848bd0 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-14T03:40:36Z |
| publishDate | 2019-08-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-f1b41588477840a2b617ed6a35848bd02022-12-21T23:18:29ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882019-08-0114310.3329/bjp.v14i3.40803ANTIDEPRESSANT-LIKE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AGARICUS BLAZEI MURRILL IN STRESSED AND UNSTRESSED MICEIsrar ul Haq0Muhammad Aslam1Hammad Ahmed2Nuzhat Sultana3Department of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi, PakistanDepartment of Pharmacology, Faculty of Pharmacy, University of Sindh, Jamshoro, PakistanDepartment of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi, PakistanDepartment of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, PakistanThe objective of this study was to investigate the antidepressant activity of Agaricus blazei Murrill in stressed and unstressed swiss albino mice. Antidepressant activity was evaluated by consecutive oral administration of two doses i.e. (273 mg/kg and 819 mg/kg) of hydroalcoholic extract of Agaricus blazei Murrill. Mice were immobilized to induce stress. Fluoxetine 20 mg/kg orally was given to stressed and unstressed animals and immobility time was noted by using forced swim test and tail suspension test. The concentration of plasma nitrite was also evaluated in stressed and unstressed mice. The effect of prazosin (a1-adrenoceptor antagonist), p-CPA (parachlorophenylalanine – tryptophan hydroxylase inhibitor) and 7-nitroindazole (nNOS inhibitor) on the antidepressant activity of Agaricus blazei Murrill was also evaluated. Agaricus blazei Murrill (273 mg/kg, 819 mg/kg, and fluoxetine 20 mg/kg, p.o.) significantly decreased the duration of immobility time in stressed and unstressed mice, showing significant antidepressant activity. No substantial change was found in the locomotor activity. However, significant reduction in the level of plasma nitrite was also noted in stressed mice. Hydroalcoholic extract of Agaricus blazei Murrill showed prominent antidepressant activity in mice.https://www.banglajol.info/index.php/BJP/article/view/40803Agaricus blazeiForced swim testTail suspension test |
| spellingShingle | Israr ul Haq Muhammad Aslam Hammad Ahmed Nuzhat Sultana ANTIDEPRESSANT-LIKE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AGARICUS BLAZEI MURRILL IN STRESSED AND UNSTRESSED MICE Bangladesh Journal of Pharmacology Agaricus blazei Forced swim test Tail suspension test |
| title | ANTIDEPRESSANT-LIKE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AGARICUS BLAZEI MURRILL IN STRESSED AND UNSTRESSED MICE |
| title_full | ANTIDEPRESSANT-LIKE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AGARICUS BLAZEI MURRILL IN STRESSED AND UNSTRESSED MICE |
| title_fullStr | ANTIDEPRESSANT-LIKE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AGARICUS BLAZEI MURRILL IN STRESSED AND UNSTRESSED MICE |
| title_full_unstemmed | ANTIDEPRESSANT-LIKE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AGARICUS BLAZEI MURRILL IN STRESSED AND UNSTRESSED MICE |
| title_short | ANTIDEPRESSANT-LIKE ACTIVITY OF HYDROALCOHOLIC EXTRACT OF AGARICUS BLAZEI MURRILL IN STRESSED AND UNSTRESSED MICE |
| title_sort | antidepressant like activity of hydroalcoholic extract of agaricus blazei murrill in stressed and unstressed mice |
| topic | Agaricus blazei Forced swim test Tail suspension test |
| url | https://www.banglajol.info/index.php/BJP/article/view/40803 |
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