Preoperative Chemoradiotherapy followed by Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: a Single Center Experience in Southern Taiwan
Objective: In general, the typical outcome of patients with locally advanced esophageal squamous cell carcinoma is poor. Recently, attempts have been made to improve survival of patients with esophageal cancer using preoperative chemoradiotherapy followed by surgery. The experience of a single cente...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2014-12-01
|
Series: | Journal of Cancer Research and Practice |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2311300616300453 |
_version_ | 1811198826106585088 |
---|---|
author | Chien-Ming Lo Yen-Yu Chen Yen-Hao Chen Tai-Jan Chiu Shun-Chen Huang You-Ming Wang Fu-Min Fang Yi-Chun Chiu Ming-Jeng Hsieh Shau-Hsuan Li Hung-I Lu |
author_facet | Chien-Ming Lo Yen-Yu Chen Yen-Hao Chen Tai-Jan Chiu Shun-Chen Huang You-Ming Wang Fu-Min Fang Yi-Chun Chiu Ming-Jeng Hsieh Shau-Hsuan Li Hung-I Lu |
author_sort | Chien-Ming Lo |
collection | DOAJ |
description | Objective: In general, the typical outcome of patients with locally advanced esophageal squamous cell carcinoma is poor. Recently, attempts have been made to improve survival of patients with esophageal cancer using preoperative chemoradiotherapy followed by surgery. The experience of a single center in Southern Taiwan with esophageal squamous cell carcinoma was reviewed to determine which clinicopathologic variables could predict survival.
Methods: One hundred and one patients with diagnosed esophageal squamous cell carcinoma who were treated with preoperative chemoradiotherapy followed by surgery at Kaohsiung Chang Gung Memorial Hospital were retrospectively reviewed. Univariate and multivariate survival analyses were performed using log-rank and Cox proportional hazards models.
Results: Of these 101 patients, 26% (26 of 101) achieved a pathologic complete response to treatment. Univariate analysis revealed that clinical T4 disease and absence of pathologic complete response were significantly associated with worse overall survival and disease-free survival. The 3-year overall survival rates were 50% and 24% in patients with clinical T1~3 and T4 disease, respectively (P = 0.01). The 3-year overall survival rates were 68% and 28% in patients with and without pathologic complete response, respectively (P = 0.001). Multivariate analysis also showed that clinical T4 disease and absence of pathologic complete response were independently associated with inferior overall and disease-free survival.
Conclusions: Clinical T4 disease and absence of pathologic complete response were associated with significantly worse survival in patients with esophageal squamous cell carcinoma receiving preoperative chemoradiotherapy followed by surgery. |
first_indexed | 2024-04-12T01:37:52Z |
format | Article |
id | doaj.art-f1b607d8d87f442493083ad41b60be8b |
institution | Directory Open Access Journal |
issn | 2311-3006 |
language | English |
last_indexed | 2024-04-12T01:37:52Z |
publishDate | 2014-12-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Journal of Cancer Research and Practice |
spelling | doaj.art-f1b607d8d87f442493083ad41b60be8b2022-12-22T03:53:17ZengWolters Kluwer Medknow PublicationsJournal of Cancer Research and Practice2311-30062014-12-011320821910.6323/JCRP.2014.1.3.04Preoperative Chemoradiotherapy followed by Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: a Single Center Experience in Southern TaiwanChien-Ming Lo0Yen-Yu Chen1Yen-Hao Chen2Tai-Jan Chiu3Shun-Chen Huang4You-Ming Wang5Fu-Min Fang6Yi-Chun Chiu7Ming-Jeng Hsieh8Shau-Hsuan Li9Hung-I Lu10Department of Thoracic & Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Thoracic & Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Hematology-Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Hematology-Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDeaprtment of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDeaprtment of Radiation Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Hepato-Gastroenterlogy, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Thoracic & Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Hematology-Oncology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanDepartment of Thoracic & Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, TaiwanObjective: In general, the typical outcome of patients with locally advanced esophageal squamous cell carcinoma is poor. Recently, attempts have been made to improve survival of patients with esophageal cancer using preoperative chemoradiotherapy followed by surgery. The experience of a single center in Southern Taiwan with esophageal squamous cell carcinoma was reviewed to determine which clinicopathologic variables could predict survival. Methods: One hundred and one patients with diagnosed esophageal squamous cell carcinoma who were treated with preoperative chemoradiotherapy followed by surgery at Kaohsiung Chang Gung Memorial Hospital were retrospectively reviewed. Univariate and multivariate survival analyses were performed using log-rank and Cox proportional hazards models. Results: Of these 101 patients, 26% (26 of 101) achieved a pathologic complete response to treatment. Univariate analysis revealed that clinical T4 disease and absence of pathologic complete response were significantly associated with worse overall survival and disease-free survival. The 3-year overall survival rates were 50% and 24% in patients with clinical T1~3 and T4 disease, respectively (P = 0.01). The 3-year overall survival rates were 68% and 28% in patients with and without pathologic complete response, respectively (P = 0.001). Multivariate analysis also showed that clinical T4 disease and absence of pathologic complete response were independently associated with inferior overall and disease-free survival. Conclusions: Clinical T4 disease and absence of pathologic complete response were associated with significantly worse survival in patients with esophageal squamous cell carcinoma receiving preoperative chemoradiotherapy followed by surgery.http://www.sciencedirect.com/science/article/pii/S2311300616300453esophageal cancersquamous cell carcinomapreoperative chemoradiotherapyesophagectomypathologic complete response |
spellingShingle | Chien-Ming Lo Yen-Yu Chen Yen-Hao Chen Tai-Jan Chiu Shun-Chen Huang You-Ming Wang Fu-Min Fang Yi-Chun Chiu Ming-Jeng Hsieh Shau-Hsuan Li Hung-I Lu Preoperative Chemoradiotherapy followed by Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: a Single Center Experience in Southern Taiwan Journal of Cancer Research and Practice esophageal cancer squamous cell carcinoma preoperative chemoradiotherapy esophagectomy pathologic complete response |
title | Preoperative Chemoradiotherapy followed by Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: a Single Center Experience in Southern Taiwan |
title_full | Preoperative Chemoradiotherapy followed by Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: a Single Center Experience in Southern Taiwan |
title_fullStr | Preoperative Chemoradiotherapy followed by Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: a Single Center Experience in Southern Taiwan |
title_full_unstemmed | Preoperative Chemoradiotherapy followed by Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: a Single Center Experience in Southern Taiwan |
title_short | Preoperative Chemoradiotherapy followed by Surgery in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: a Single Center Experience in Southern Taiwan |
title_sort | preoperative chemoradiotherapy followed by surgery in patients with locally advanced esophageal squamous cell carcinoma a single center experience in southern taiwan |
topic | esophageal cancer squamous cell carcinoma preoperative chemoradiotherapy esophagectomy pathologic complete response |
url | http://www.sciencedirect.com/science/article/pii/S2311300616300453 |
work_keys_str_mv | AT chienminglo preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT yenyuchen preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT yenhaochen preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT taijanchiu preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT shunchenhuang preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT youmingwang preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT fuminfang preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT yichunchiu preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT mingjenghsieh preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT shauhsuanli preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan AT hungilu preoperativechemoradiotherapyfollowedbysurgeryinpatientswithlocallyadvancedesophagealsquamouscellcarcinomaasinglecenterexperienceinsoutherntaiwan |