Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis
Abstract Background and aim The association between iron-metabolism-related variables and liver fibrosis in chronic hepatitis C and nonalcoholic fatty liver disease is now well known. However, the relationship has not been extensively studied in autoimmune hepatitis (AIH). We aimed to investigate th...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-022-02098-z |
| _version_ | 1798016296078540800 |
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| author | Qingling Chen Min Gao Hang Yang Ling Mei Rui Zhong Ping Han Peiyan Liu Lili Zhao Jing Wang Jia Li |
| author_facet | Qingling Chen Min Gao Hang Yang Ling Mei Rui Zhong Ping Han Peiyan Liu Lili Zhao Jing Wang Jia Li |
| author_sort | Qingling Chen |
| collection | DOAJ |
| description | Abstract Background and aim The association between iron-metabolism-related variables and liver fibrosis in chronic hepatitis C and nonalcoholic fatty liver disease is now well known. However, the relationship has not been extensively studied in autoimmune hepatitis (AIH). We aimed to investigate the association between variables associated with iron metabolism and advanced liver fibrosis among untreated patients with AIH. Methods Ninety-seven untreated AIH patients were enrolled in this cross-sectional study. All participants underwent iron metabolism index detection and liver biopsy. Multiple logistic regression analysis was used to explore the association of iron-metabolism-related variables with advanced liver fibrosis. Results Among the 97 AIH patients, 38 (39.2%) had advanced liver fibrosis, and 59 (60.8%) did not. In multivariate logistic regression analysis, immunoglobulin G (odds ratio [OR], 1.123; 95% confidence interval [CI] 1.023–1.232, P = 0.014), platelet count (OR 0.988; 95% CI 0.979–0.997, P = 0.013), prothrombin time (OR 1.758; 95% CI 1.143–2.704, P = 0.010) and ferritin (OR 1.002; 95% CI 1.001–1.004, P = 0.012) were independent risk factors for predicting advanced liver fibrosis in AIH patients. Conclusion Higher serum ferritin was independently associated with advanced liver fibrosis among patients with treatment-naive AIH. |
| first_indexed | 2024-04-11T15:48:39Z |
| format | Article |
| id | doaj.art-f1b6d1c2ea42426eb7e99346e3c34a11 |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-04-11T15:48:39Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-f1b6d1c2ea42426eb7e99346e3c34a112022-12-22T04:15:27ZengBMCBMC Gastroenterology1471-230X2022-01-012211910.1186/s12876-022-02098-zSerum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitisQingling Chen0Min Gao1Hang Yang2Ling Mei3Rui Zhong4Ping Han5Peiyan Liu6Lili Zhao7Jing Wang8Jia Li9Department of Hepatology, Second People’s Clinical College of Tianjin Medical UniversityDepartment of Hepatology, Tianjin Second People’s HospitalDepartment of Hepatology, Second People’s Clinical College of Tianjin Medical UniversityDepartment of Hepatology, Second People’s Clinical College of Tianjin Medical UniversityDepartment of Neurology, The First Hospital of Jilin UniversityDepartment of Hepatology, Tianjin Second People’s HospitalDepartment of Hepatology, Second People’s Clinical College of Tianjin Medical UniversityDepartment of Hepatology, Tianjin Second People’s HospitalDepartment of Hepatology, Tianjin Second People’s HospitalDepartment of Hepatology, Tianjin Second People’s HospitalAbstract Background and aim The association between iron-metabolism-related variables and liver fibrosis in chronic hepatitis C and nonalcoholic fatty liver disease is now well known. However, the relationship has not been extensively studied in autoimmune hepatitis (AIH). We aimed to investigate the association between variables associated with iron metabolism and advanced liver fibrosis among untreated patients with AIH. Methods Ninety-seven untreated AIH patients were enrolled in this cross-sectional study. All participants underwent iron metabolism index detection and liver biopsy. Multiple logistic regression analysis was used to explore the association of iron-metabolism-related variables with advanced liver fibrosis. Results Among the 97 AIH patients, 38 (39.2%) had advanced liver fibrosis, and 59 (60.8%) did not. In multivariate logistic regression analysis, immunoglobulin G (odds ratio [OR], 1.123; 95% confidence interval [CI] 1.023–1.232, P = 0.014), platelet count (OR 0.988; 95% CI 0.979–0.997, P = 0.013), prothrombin time (OR 1.758; 95% CI 1.143–2.704, P = 0.010) and ferritin (OR 1.002; 95% CI 1.001–1.004, P = 0.012) were independent risk factors for predicting advanced liver fibrosis in AIH patients. Conclusion Higher serum ferritin was independently associated with advanced liver fibrosis among patients with treatment-naive AIH.https://doi.org/10.1186/s12876-022-02098-zAutoimmune hepatitisFerritinIron metabolism disordersLiver fibrosis |
| spellingShingle | Qingling Chen Min Gao Hang Yang Ling Mei Rui Zhong Ping Han Peiyan Liu Lili Zhao Jing Wang Jia Li Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis BMC Gastroenterology Autoimmune hepatitis Ferritin Iron metabolism disorders Liver fibrosis |
| title | Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis |
| title_full | Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis |
| title_fullStr | Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis |
| title_full_unstemmed | Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis |
| title_short | Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive autoimmune hepatitis |
| title_sort | serum ferritin levels are associated with advanced liver fibrosis in treatment naive autoimmune hepatitis |
| topic | Autoimmune hepatitis Ferritin Iron metabolism disorders Liver fibrosis |
| url | https://doi.org/10.1186/s12876-022-02098-z |
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