A multimodal approach to eye melanoma: patterns of care and related complications
We describe the results of multimodal treatment of uveal and conjunctival melanomas. A retrospective analysis was performed on 54 patients treated with a multimodal approach between 2003 and 2008 in a single institution. Main outcome measures were survival, enucleation rate, local tumor control, vis...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2011-12-01
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| Series: | Oncology Reviews |
| Subjects: | |
| Online Access: | http://www.oncologyreviews.org/index.php/or/article/view/76 |
| _version_ | 1828076052154417152 |
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| author | Maria Grazia Fabrini Federica Genovesi-Ebert Franco Perrone Letizia Forte Antonella Grandinetti Stanislao Rizzo Luca Cionini |
| author_facet | Maria Grazia Fabrini Federica Genovesi-Ebert Franco Perrone Letizia Forte Antonella Grandinetti Stanislao Rizzo Luca Cionini |
| author_sort | Maria Grazia Fabrini |
| collection | DOAJ |
| description | We describe the results of multimodal treatment of uveal and conjunctival melanomas. A retrospective analysis was performed on 54 patients treated with a multimodal approach between 2003 and 2008 in a single institution. Main outcome measures were survival, enucleation rate, local tumor control, visual function preservation and complications associated with treatments. The median follow-up was 33.4 months. The 5-year overall survival was 95.3%, the local recurrence was 3.7% and the 5-year enucleation was 9.4%. Vision preservation was achieved in 84% of cases. Observed complications were cataract, retinal detachment, diplopia, glaucoma, retinopathy, optic neuropathy and scleral necrosis. A careful consideration of treatment of uveal melanoma in this study allowed us to obtain the survival rates and visual outcomes similar to previously published results, with a very small incidence of complications. the results must be interpreted in the light of recent findings on the genetic pattern of uveal melanoma. |
| first_indexed | 2024-04-11T02:09:02Z |
| format | Article |
| id | doaj.art-f1b6d847b0974386be8082ebe88c7775 |
| institution | Directory Open Access Journal |
| issn | 1970-5557 1970-5565 |
| language | English |
| last_indexed | 2024-04-11T02:09:02Z |
| publishDate | 2011-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Oncology Reviews |
| spelling | doaj.art-f1b6d847b0974386be8082ebe88c77752023-01-03T02:38:56ZengFrontiers Media S.A.Oncology Reviews1970-55571970-55652011-12-013110.4081/oncol.2009.4170A multimodal approach to eye melanoma: patterns of care and related complicationsMaria Grazia Fabrini0Federica Genovesi-Ebert1Franco Perrone2Letizia Forte3Antonella Grandinetti4Stanislao Rizzo5Luca Cionini6Radiotherapy Division, Pisa University Hospital, PisaOphthalmic Surgery Division, Pisa University Hospital, PisaHealth Physics Division, Pisa University Hospital, PisaRadiotherapy Division, Pisa University Hospital, PisaRadiotherapy Division, Pisa University Hospital, PisaOphthalmic Surgery Division, Pisa University Hospital, PisaRadiotherapy Division, Pisa University Hospital, PisaWe describe the results of multimodal treatment of uveal and conjunctival melanomas. A retrospective analysis was performed on 54 patients treated with a multimodal approach between 2003 and 2008 in a single institution. Main outcome measures were survival, enucleation rate, local tumor control, visual function preservation and complications associated with treatments. The median follow-up was 33.4 months. The 5-year overall survival was 95.3%, the local recurrence was 3.7% and the 5-year enucleation was 9.4%. Vision preservation was achieved in 84% of cases. Observed complications were cataract, retinal detachment, diplopia, glaucoma, retinopathy, optic neuropathy and scleral necrosis. A careful consideration of treatment of uveal melanoma in this study allowed us to obtain the survival rates and visual outcomes similar to previously published results, with a very small incidence of complications. the results must be interpreted in the light of recent findings on the genetic pattern of uveal melanoma.http://www.oncologyreviews.org/index.php/or/article/view/76Melanoma - Uvea - Conjunctiva - Eye - Brachytherapy - Plaque - Bevacizumab |
| spellingShingle | Maria Grazia Fabrini Federica Genovesi-Ebert Franco Perrone Letizia Forte Antonella Grandinetti Stanislao Rizzo Luca Cionini A multimodal approach to eye melanoma: patterns of care and related complications Oncology Reviews Melanoma - Uvea - Conjunctiva - Eye - Brachytherapy - Plaque - Bevacizumab |
| title | A multimodal approach to eye melanoma: patterns of care and related complications |
| title_full | A multimodal approach to eye melanoma: patterns of care and related complications |
| title_fullStr | A multimodal approach to eye melanoma: patterns of care and related complications |
| title_full_unstemmed | A multimodal approach to eye melanoma: patterns of care and related complications |
| title_short | A multimodal approach to eye melanoma: patterns of care and related complications |
| title_sort | multimodal approach to eye melanoma patterns of care and related complications |
| topic | Melanoma - Uvea - Conjunctiva - Eye - Brachytherapy - Plaque - Bevacizumab |
| url | http://www.oncologyreviews.org/index.php/or/article/view/76 |
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