Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents
Ali A Ghweil, Mohamad M Helal Department of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt Background: We performed a case-series analysis of reactivation of herpesvirus in patients with hepatitis C virus (HCV) infection treated with direct-act...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-04-01
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| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/reactivation-of-herpesvirus-in-patients-with-hepatitis-c-treated-with--peer-reviewed-article-IDR |
| _version_ | 1818174524568371200 |
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| author | Ghweil AA Helal MM |
| author_facet | Ghweil AA Helal MM |
| author_sort | Ghweil AA |
| collection | DOAJ |
| description | Ali A Ghweil, Mohamad M Helal Department of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt Background: We performed a case-series analysis of reactivation of herpesvirus in patients with hepatitis C virus (HCV) infection treated with direct-acting antiviral (DAA) agents. Methods: Eight cases were detected among 100 treated patients with DAA regimens in Qena University Hospital from June 2016 to June 2017. Herpesvirus was reactivated in eight patients who received DAA therapy. None of the cases had risk factor for herpes zoster reactivation. Results: The DAA regimens used were sofosbuvir/daclatasvir in six cases and sofosbuvir/ledipasvir in two cases. Immune changes that follow HCV clearance might lead to reactivation of other viruses, such as herpesvirus. Conclusion: Patients with HCV infection suspected of having herpesvirus infection should be treated promptly. Keywords: HCV, HZ, DAA |
| first_indexed | 2024-12-11T19:45:46Z |
| format | Article |
| id | doaj.art-f1b979a107a04c04b8f476a12461bc8b |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-12-11T19:45:46Z |
| publishDate | 2019-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-f1b979a107a04c04b8f476a12461bc8b2022-12-22T00:52:55ZengDove Medical PressInfection and Drug Resistance1178-69732019-04-01Volume 1275976244872Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agentsGhweil AAHelal MMAli A Ghweil, Mohamad M Helal Department of Tropical Medicine and Gastroenterology, Qena Faculty of Medicine, South Valley University, Qena, Egypt Background: We performed a case-series analysis of reactivation of herpesvirus in patients with hepatitis C virus (HCV) infection treated with direct-acting antiviral (DAA) agents. Methods: Eight cases were detected among 100 treated patients with DAA regimens in Qena University Hospital from June 2016 to June 2017. Herpesvirus was reactivated in eight patients who received DAA therapy. None of the cases had risk factor for herpes zoster reactivation. Results: The DAA regimens used were sofosbuvir/daclatasvir in six cases and sofosbuvir/ledipasvir in two cases. Immune changes that follow HCV clearance might lead to reactivation of other viruses, such as herpesvirus. Conclusion: Patients with HCV infection suspected of having herpesvirus infection should be treated promptly. Keywords: HCV, HZ, DAAhttps://www.dovepress.com/reactivation-of-herpesvirus-in-patients-with-hepatitis-c-treated-with--peer-reviewed-article-IDRHCVHZDAA |
| spellingShingle | Ghweil AA Helal MM Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents Infection and Drug Resistance HCV HZ DAA |
| title | Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents |
| title_full | Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents |
| title_fullStr | Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents |
| title_full_unstemmed | Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents |
| title_short | Reactivation of herpesvirus in patients with hepatitis C treated with direct-acting antiviral agents |
| title_sort | reactivation of herpesvirus in patients with hepatitis c treated with direct acting antiviral agents |
| topic | HCV HZ DAA |
| url | https://www.dovepress.com/reactivation-of-herpesvirus-in-patients-with-hepatitis-c-treated-with--peer-reviewed-article-IDR |
| work_keys_str_mv | AT ghweilaa reactivationofherpesvirusinpatientswithhepatitisctreatedwithdirectactingantiviralagents AT helalmm reactivationofherpesvirusinpatientswithhepatitisctreatedwithdirectactingantiviralagents |