Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study
Abstract Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on th...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-10104-8 |
| _version_ | 1818835162531627008 |
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| author | Hikaru Takeuchi Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Yuki Yamamoto Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Takamitsu Shinada Kohei Sakaki Yuko Sassa Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Magistro Daniele Ryuta Kawashima |
| author_facet | Hikaru Takeuchi Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Yuki Yamamoto Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Takamitsu Shinada Kohei Sakaki Yuko Sassa Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Magistro Daniele Ryuta Kawashima |
| author_sort | Hikaru Takeuchi |
| collection | DOAJ |
| description | Abstract Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on the available evidence, we hypothesized that diverse CCAs are all positively but only weakly associated with rGMV in widespread brain areas. To test this hypothesis, we used the data from a large sample of healthy young adults [776 males and 560 females; mean age: 20.8 years, standard deviation (SD) = 0.8] and investigated associations between rGMV and scores on multiple CCA tasks (including non-verbal reasoning, verbal working memory, Stroop interference, and complex processing speed tasks involving spatial cognition and reasoning). Better performance scores on all tasks except non-verbal reasoning were associated with greater rGMV across widespread brain areas. The effect sizes of individual associations were generally low, consistent with our previous studies. The lack of strong correlations between rGMV and specific CCAs, combined with stringent corrections for multiple comparisons, may lead to different and diverse findings in the field. |
| first_indexed | 2024-12-19T02:46:20Z |
| format | Article |
| id | doaj.art-f1ba198772ad42268f38472c56c04c1a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T02:46:20Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f1ba198772ad42268f38472c56c04c1a2022-12-21T20:38:53ZengNature PortfolioScientific Reports2045-23222017-08-017111610.1038/s41598-017-10104-8Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample studyHikaru Takeuchi0Yasuyuki Taki1Rui Nouchi2Ryoichi Yokoyama3Yuka Kotozaki4Seishu Nakagawa5Atsushi Sekiguchi6Kunio Iizuka7Yuki Yamamoto8Sugiko Hanawa9Tsuyoshi Araki10Carlos Makoto Miyauchi11Takamitsu Shinada12Kohei Sakaki13Yuko Sassa14Takayuki Nozawa15Shigeyuki Ikeda16Susumu Yokota17Magistro Daniele18Ryuta Kawashima19Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku UniversityDivision of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku UniversityCreative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Science, Tohoku UniversitySchool of Medicine, Kobe UniversityDivision of Clinical research, Medical-Industry Translational Research Center, Fukushima Medical University School of MedicineDepartment of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, KodairaDepartment of Psychiatry, Tohoku University Graduate School of MedicineDepartment of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku UniversitySmart Ageing International Research Center, Institute of Development, Aging and Cancer, Tohoku UniversityGraduate School of Arts and Sciences, Department of General Systems Studies, The University of TokyoDepartment of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Functional Brain Imaging, Institute of Development, Aging and Cancer, Tohoku UniversityDivision of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku UniversityDepartment of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku UniversityDivision of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku UniversitySchool of Electronic, Electrical and Systems Engineering, Loughborough UniversityDivision of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku UniversityAbstract Correlations between regional gray matter volume (rGMV) and psychometric test scores have been measured to investigate the neural bases for individual differences in complex cognitive abilities (CCAs). However, such studies have yielded different rGMV correlates of the same CCA. Based on the available evidence, we hypothesized that diverse CCAs are all positively but only weakly associated with rGMV in widespread brain areas. To test this hypothesis, we used the data from a large sample of healthy young adults [776 males and 560 females; mean age: 20.8 years, standard deviation (SD) = 0.8] and investigated associations between rGMV and scores on multiple CCA tasks (including non-verbal reasoning, verbal working memory, Stroop interference, and complex processing speed tasks involving spatial cognition and reasoning). Better performance scores on all tasks except non-verbal reasoning were associated with greater rGMV across widespread brain areas. The effect sizes of individual associations were generally low, consistent with our previous studies. The lack of strong correlations between rGMV and specific CCAs, combined with stringent corrections for multiple comparisons, may lead to different and diverse findings in the field.https://doi.org/10.1038/s41598-017-10104-8 |
| spellingShingle | Hikaru Takeuchi Yasuyuki Taki Rui Nouchi Ryoichi Yokoyama Yuka Kotozaki Seishu Nakagawa Atsushi Sekiguchi Kunio Iizuka Yuki Yamamoto Sugiko Hanawa Tsuyoshi Araki Carlos Makoto Miyauchi Takamitsu Shinada Kohei Sakaki Yuko Sassa Takayuki Nozawa Shigeyuki Ikeda Susumu Yokota Magistro Daniele Ryuta Kawashima Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study Scientific Reports |
| title | Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study |
| title_full | Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study |
| title_fullStr | Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study |
| title_full_unstemmed | Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study |
| title_short | Global associations between regional gray matter volume and diverse complex cognitive functions: evidence from a large sample study |
| title_sort | global associations between regional gray matter volume and diverse complex cognitive functions evidence from a large sample study |
| url | https://doi.org/10.1038/s41598-017-10104-8 |
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