Modeling and affinity maturation of an anti-CD20 nanobody: a comprehensive in-silico investigation
Abstract B-cell Non-Hodgkin lymphomas are the malignancies of lymphocytes. CD20 is a membrane protein, which is highly expressed on the cell surface of the B-cells in NHL. Treatments using monoclonal antibodies (mAbs) have resulted in failure in some cases. Nanobodies (NBs), single-domain antibodies...
| Hlavní autoři: | , , , |
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| Médium: | Článek |
| Jazyk: | English |
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Nature Portfolio
2023-01-01
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| Edice: | Scientific Reports |
| On-line přístup: | https://doi.org/10.1038/s41598-023-27926-4 |