Circulating leptin and resistin levels in a Romanian rheumatoid arthritis population
Objective. Rheumatoid arthritis (RA), a chronic autoimmune disease which primarily affects the joints, is associated with various cardiometabolic comorbidities. These comorbidities, particularly metabolic syndrome, exert an altered secretion of proinflammatory adipokines that increase cardiovascular...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2020-06-01
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| Series: | Romanian Journal of Rheumatology |
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| Online Access: | https://rjr.com.ro/articles/2020.2/RJR_2020_2_Art-06.pdf |
| _version_ | 1819137164893487104 |
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| author | Cristian Vasile Petra Camelia Larisa Vonica Rodica Rahaian Iulia Berceanu Stefan Cristian Vesa Mihnea Zdrenghea Simona Rednic |
| author_facet | Cristian Vasile Petra Camelia Larisa Vonica Rodica Rahaian Iulia Berceanu Stefan Cristian Vesa Mihnea Zdrenghea Simona Rednic |
| author_sort | Cristian Vasile Petra |
| collection | DOAJ |
| description | Objective. Rheumatoid arthritis (RA), a chronic autoimmune disease which primarily affects the joints, is associated with various cardiometabolic comorbidities. These comorbidities, particularly metabolic syndrome, exert an altered secretion of proinflammatory adipokines that increase cardiovascular risk in rheumatic diseases. Leptin and resistin are two of the most important and intensely-studied adipocytokines. Increased serum levels of both leptin and resistin in RA patients have been previously reported but the results are conflicting. This study aimed to investigate the serum levels of leptin and resistin in a Romanian rheumatoid arthritis population and to compare them with the serum concentrations of healthy controls.
Material and methods. We assessed clinical and biochemical parameters in 84 RA patients and 44 healthy controls with the help of specific enzyme-linked immunosorbent assays.
Results. Mean disease duration was 12.1±9.6 years and RA patients had a mean disease activity score of 4.24±1.3, as assessed by Disease Activity Score-28 using C-reactive protein (DAS-28 CRP). RA patients showed significantly higher concentrations of serum leptin than controls (median 28.63 ng/ml vs. 21.16 ng/ml, p=.03) while there was a trend for an elevated serum resistin level in RA patients (median 15.98 ng/ml vs. 14.05 ng/ml) which did not reach statistical significance (p = 0.41).
Conclusions. The current study shows a significant increase in circulating leptin but not resistin in RA patients than in controls. The link between adipokines, the chronic pro-inflammatory state and consequent cardiometabolic complications warrants further larger and longitudinally-designed studies. |
| first_indexed | 2024-12-22T10:46:32Z |
| format | Article |
| id | doaj.art-f1bbd6742a2747da9fe202f1c7009796 |
| institution | Directory Open Access Journal |
| issn | 1843-0791 2069-6086 |
| language | English |
| last_indexed | 2024-12-22T10:46:32Z |
| publishDate | 2020-06-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Rheumatology |
| spelling | doaj.art-f1bbd6742a2747da9fe202f1c70097962022-12-21T18:28:56ZengAmaltea Medical Publishing HouseRomanian Journal of Rheumatology1843-07912069-60862020-06-01292798310.37897/RJR.2020.2.6Circulating leptin and resistin levels in a Romanian rheumatoid arthritis populationCristian Vasile Petra0Camelia Larisa Vonica1Rodica Rahaian2Iulia Berceanu3Stefan Cristian Vesa4Mihnea Zdrenghea5Simona Rednic6Rheumatology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania Department of Diabetes, Nutrition and Metabolic Diseases, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDivision of Immunology, Emergency County Hospital Cluj, Cluj-Napoca, Romania Department of Hematology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; “Ion Chiricuta” Oncology Institute, Cluj-Napoca, RomaniaPharmacology, Toxicology and Clinical Pharmacology Departament, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania Department of Hematology, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; “Ion Chiricuta” Oncology Institute, Cluj-Napoca, RomaniaRheumatology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaObjective. Rheumatoid arthritis (RA), a chronic autoimmune disease which primarily affects the joints, is associated with various cardiometabolic comorbidities. These comorbidities, particularly metabolic syndrome, exert an altered secretion of proinflammatory adipokines that increase cardiovascular risk in rheumatic diseases. Leptin and resistin are two of the most important and intensely-studied adipocytokines. Increased serum levels of both leptin and resistin in RA patients have been previously reported but the results are conflicting. This study aimed to investigate the serum levels of leptin and resistin in a Romanian rheumatoid arthritis population and to compare them with the serum concentrations of healthy controls. Material and methods. We assessed clinical and biochemical parameters in 84 RA patients and 44 healthy controls with the help of specific enzyme-linked immunosorbent assays. Results. Mean disease duration was 12.1±9.6 years and RA patients had a mean disease activity score of 4.24±1.3, as assessed by Disease Activity Score-28 using C-reactive protein (DAS-28 CRP). RA patients showed significantly higher concentrations of serum leptin than controls (median 28.63 ng/ml vs. 21.16 ng/ml, p=.03) while there was a trend for an elevated serum resistin level in RA patients (median 15.98 ng/ml vs. 14.05 ng/ml) which did not reach statistical significance (p = 0.41). Conclusions. The current study shows a significant increase in circulating leptin but not resistin in RA patients than in controls. The link between adipokines, the chronic pro-inflammatory state and consequent cardiometabolic complications warrants further larger and longitudinally-designed studies.https://rjr.com.ro/articles/2020.2/RJR_2020_2_Art-06.pdfleptinresistinadipokinesrheumatoid arthritiscardiometabolic risk |
| spellingShingle | Cristian Vasile Petra Camelia Larisa Vonica Rodica Rahaian Iulia Berceanu Stefan Cristian Vesa Mihnea Zdrenghea Simona Rednic Circulating leptin and resistin levels in a Romanian rheumatoid arthritis population Romanian Journal of Rheumatology leptin resistin adipokines rheumatoid arthritis cardiometabolic risk |
| title | Circulating leptin and resistin levels in a Romanian rheumatoid arthritis population |
| title_full | Circulating leptin and resistin levels in a Romanian rheumatoid arthritis population |
| title_fullStr | Circulating leptin and resistin levels in a Romanian rheumatoid arthritis population |
| title_full_unstemmed | Circulating leptin and resistin levels in a Romanian rheumatoid arthritis population |
| title_short | Circulating leptin and resistin levels in a Romanian rheumatoid arthritis population |
| title_sort | circulating leptin and resistin levels in a romanian rheumatoid arthritis population |
| topic | leptin resistin adipokines rheumatoid arthritis cardiometabolic risk |
| url | https://rjr.com.ro/articles/2020.2/RJR_2020_2_Art-06.pdf |
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