Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers
Electrospun nanofibers were prepared from furosemide-containing hydroxypropyl cellulose and poly(vinylpyrrolidone) aqueous solutions using different solubility enhancers. In one case, a solubilizer, triethanolamine, was applied, while in the other case a pH-modifier, sodium hydroxide, was applied. S...
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| Format: | Article |
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MDPI AG
2020-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/12/4/385 |
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| author | Andrea Kovács Adrienn Kazsoki Balázs Démuth Bernadett Szirányi János Madarász Károly Süvegh Romána Zelkó |
| author_facet | Andrea Kovács Adrienn Kazsoki Balázs Démuth Bernadett Szirányi János Madarász Károly Süvegh Romána Zelkó |
| author_sort | Andrea Kovács |
| collection | DOAJ |
| description | Electrospun nanofibers were prepared from furosemide-containing hydroxypropyl cellulose and poly(vinylpyrrolidone) aqueous solutions using different solubility enhancers. In one case, a solubilizer, triethanolamine, was applied, while in the other case a pH-modifier, sodium hydroxide, was applied. Scanning electron microscopy (SEM) was carried out for morphological characterization of the fibers. The SEM images indicated similar mean diameter size of the two fibrous formulations. However, in contrast to the NaOH-containing fibers of normal diameter distribution, the triethanolamine-containing fibers showed approximately normal diameter distribution, possibly due to their plasticizing effect and the consequent slightly ribbon-like morphology. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), powder X-ray diffraction (XRD) and positron annihilation lifetime spectroscopy (PALS) were applied for microstructural characterization. The FTIR measurements confirmed that furosemide salt was formed in both cases. There was no sign of any crystallinity based on the XRD measurements. However, the PALS highlighted the differences in the average o-Ps lifetime values and distributions of the furosemide-loaded fibrous formulations. The two types of electrospun nanofibrous formulations containing amorphous furosemide salt showed similar macrostructures but different microstructural characteristics depending on the type of solubility enhancers, which lead to altered storage stability. |
| first_indexed | 2024-03-10T20:17:53Z |
| format | Article |
| id | doaj.art-f1bccbb8aec44c689fb61cfe783cf114 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T20:17:53Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f1bccbb8aec44c689fb61cfe783cf1142023-11-19T22:28:45ZengMDPI AGPharmaceutics1999-49232020-04-0112438510.3390/pharmaceutics12040385Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun NanofibersAndrea Kovács0Adrienn Kazsoki1Balázs Démuth2Bernadett Szirányi3János Madarász4Károly Süvegh5Romána Zelkó6Gedeon Richter Plc., Formulation R&D, Gyömrői Street 19-21, H-1103 Budapest, HungaryUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, HungaryGedeon Richter Plc., Formulation R&D, Gyömrői Street 19-21, H-1103 Budapest, HungaryGedeon Richter Plc., Formulation R&D, Gyömrői Street 19-21, H-1103 Budapest, HungaryDepartment of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szent Gellért tér 4, H-1111 Budapest, HungaryLaboratory of Nuclear Chemistry, Eötvös Loránd University/HAS Chemical Research Center, P.O. Box 32, H-1518 Budapest, HungaryUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes Endre Street 7-9, H-1092 Budapest, HungaryElectrospun nanofibers were prepared from furosemide-containing hydroxypropyl cellulose and poly(vinylpyrrolidone) aqueous solutions using different solubility enhancers. In one case, a solubilizer, triethanolamine, was applied, while in the other case a pH-modifier, sodium hydroxide, was applied. Scanning electron microscopy (SEM) was carried out for morphological characterization of the fibers. The SEM images indicated similar mean diameter size of the two fibrous formulations. However, in contrast to the NaOH-containing fibers of normal diameter distribution, the triethanolamine-containing fibers showed approximately normal diameter distribution, possibly due to their plasticizing effect and the consequent slightly ribbon-like morphology. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), powder X-ray diffraction (XRD) and positron annihilation lifetime spectroscopy (PALS) were applied for microstructural characterization. The FTIR measurements confirmed that furosemide salt was formed in both cases. There was no sign of any crystallinity based on the XRD measurements. However, the PALS highlighted the differences in the average o-Ps lifetime values and distributions of the furosemide-loaded fibrous formulations. The two types of electrospun nanofibrous formulations containing amorphous furosemide salt showed similar macrostructures but different microstructural characteristics depending on the type of solubility enhancers, which lead to altered storage stability.https://www.mdpi.com/1999-4923/12/4/385electrospinningnanofiberfurosemidemorphologyphysical-chemical characterizationmicrostructural distinction |
| spellingShingle | Andrea Kovács Adrienn Kazsoki Balázs Démuth Bernadett Szirányi János Madarász Károly Süvegh Romána Zelkó Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers Pharmaceutics electrospinning nanofiber furosemide morphology physical-chemical characterization microstructural distinction |
| title | Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers |
| title_full | Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers |
| title_fullStr | Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers |
| title_full_unstemmed | Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers |
| title_short | Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers |
| title_sort | influence of aqueous solubility enhancing excipients on the microstructural characteristics of furosemide loaded electrospun nanofibers |
| topic | electrospinning nanofiber furosemide morphology physical-chemical characterization microstructural distinction |
| url | https://www.mdpi.com/1999-4923/12/4/385 |
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