A New Geldanamycin Analogue from Streptomyces hygroscopicus
A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerabl...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-03-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/3/1161/ |
| _version_ | 1811266073526272000 |
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| author | Hao Zhang Guang-Zhi Sun Xiang Li Hong-Yu Pan Yan-Sheng Zhang |
| author_facet | Hao Zhang Guang-Zhi Sun Xiang Li Hong-Yu Pan Yan-Sheng Zhang |
| author_sort | Hao Zhang |
| collection | DOAJ |
| description | A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23). |
| first_indexed | 2024-04-12T20:35:29Z |
| format | Article |
| id | doaj.art-f1c3cb1cdcda4df4b69c69ed5b81c60f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T20:35:29Z |
| publishDate | 2010-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f1c3cb1cdcda4df4b69c69ed5b81c60f2022-12-22T03:17:37ZengMDPI AGMolecules1420-30492010-03-011531161116710.3390/molecules15031161A New Geldanamycin Analogue from Streptomyces hygroscopicusHao ZhangGuang-Zhi SunXiang LiHong-Yu PanYan-Sheng ZhangA new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).http://www.mdpi.com/1420-3049/15/3/1161/Streptomyces hygroscopicus11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycingeldanamycin |
| spellingShingle | Hao Zhang Guang-Zhi Sun Xiang Li Hong-Yu Pan Yan-Sheng Zhang A New Geldanamycin Analogue from Streptomyces hygroscopicus Molecules Streptomyces hygroscopicus 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin geldanamycin |
| title | A New Geldanamycin Analogue from Streptomyces hygroscopicus |
| title_full | A New Geldanamycin Analogue from Streptomyces hygroscopicus |
| title_fullStr | A New Geldanamycin Analogue from Streptomyces hygroscopicus |
| title_full_unstemmed | A New Geldanamycin Analogue from Streptomyces hygroscopicus |
| title_short | A New Geldanamycin Analogue from Streptomyces hygroscopicus |
| title_sort | new geldanamycin analogue from streptomyces hygroscopicus |
| topic | Streptomyces hygroscopicus 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin geldanamycin |
| url | http://www.mdpi.com/1420-3049/15/3/1161/ |
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