A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated LB
Experimental in vitro and in vivo studies support the hypothesis that heat-treated, lyophilized Lactobacillus acidophilus LB cells and concentrated, neutralized spent culture medium conserve the variety of pharmacological, antimicrobial activities of the live probiotic strain against several infecti...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2016-01-01
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| Series: | Therapeutic Advances in Gastroenterology |
| Online Access: | https://doi.org/10.1177/1756283X15602831 |
| _version_ | 1819182350328659968 |
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| author | Vanessa Liévin-Le Moal |
| author_facet | Vanessa Liévin-Le Moal |
| author_sort | Vanessa Liévin-Le Moal |
| collection | DOAJ |
| description | Experimental in vitro and in vivo studies support the hypothesis that heat-treated, lyophilized Lactobacillus acidophilus LB cells and concentrated, neutralized spent culture medium conserve the variety of pharmacological, antimicrobial activities of the live probiotic strain against several infectious agents involved in well-established acute and persistent watery diarrhoea and gastritis. Heat-treated cells and heat-stable secreted molecules trigger multiple strain-specific activities explaining the therapeutic efficacy of L. acidophilus LB. This review discusses the current body of knowledge on the antimicrobial mechanisms of action exerted by L. acidophilus LB demonstrated in in vitro and in vivo experimental studies, and the evidence for the therapeutic efficacy of this anti-infectious biotherapeutic agent proved in randomized clinical trials for the treatment of acute and persistent watery diarrhoea associated with several intestinal infectious diseases in humans. |
| first_indexed | 2024-12-22T22:44:44Z |
| format | Article |
| id | doaj.art-f1c4de8c7c5a4830a75c152a09822d36 |
| institution | Directory Open Access Journal |
| issn | 1756-283X 1756-2848 |
| language | English |
| last_indexed | 2024-12-22T22:44:44Z |
| publishDate | 2016-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Gastroenterology |
| spelling | doaj.art-f1c4de8c7c5a4830a75c152a09822d362022-12-21T18:10:07ZengSAGE PublishingTherapeutic Advances in Gastroenterology1756-283X1756-28482016-01-01910.1177/1756283X15602831A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated LBVanessa Liévin-Le MoalExperimental in vitro and in vivo studies support the hypothesis that heat-treated, lyophilized Lactobacillus acidophilus LB cells and concentrated, neutralized spent culture medium conserve the variety of pharmacological, antimicrobial activities of the live probiotic strain against several infectious agents involved in well-established acute and persistent watery diarrhoea and gastritis. Heat-treated cells and heat-stable secreted molecules trigger multiple strain-specific activities explaining the therapeutic efficacy of L. acidophilus LB. This review discusses the current body of knowledge on the antimicrobial mechanisms of action exerted by L. acidophilus LB demonstrated in in vitro and in vivo experimental studies, and the evidence for the therapeutic efficacy of this anti-infectious biotherapeutic agent proved in randomized clinical trials for the treatment of acute and persistent watery diarrhoea associated with several intestinal infectious diseases in humans.https://doi.org/10.1177/1756283X15602831 |
| spellingShingle | Vanessa Liévin-Le Moal A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated LB Therapeutic Advances in Gastroenterology |
| title | A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated LB |
| title_full | A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated LB |
| title_fullStr | A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated LB |
| title_full_unstemmed | A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated LB |
| title_short | A gastrointestinal anti-infectious biotherapeutic agent: the heat-treated LB |
| title_sort | gastrointestinal anti infectious biotherapeutic agent the heat treated lb |
| url | https://doi.org/10.1177/1756283X15602831 |
| work_keys_str_mv | AT vanessalievinlemoal agastrointestinalantiinfectiousbiotherapeuticagenttheheattreatedlb AT vanessalievinlemoal gastrointestinalantiinfectiousbiotherapeuticagenttheheattreatedlb |