PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATION
Introduction: It`s well known that the periodontitis is а complex disease initiated by bacteria, but modified by environmental factors and the host response. As any other chronic disease, the periodontal disease is influenced by the individual predisposition of the patient to develop the specific s...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Peytchinski Publishing
2021-04-01
|
| Series: | Journal of IMAB |
| Subjects: | |
| Online Access: | https://www.journal-imab-bg.org/issues-2021/issue2/2021vol27-issue2-3692-3699.pdf |
| _version_ | 1819147246878326784 |
|---|---|
| author | Antoaneta Mlachkova Zdravka Pashova-Tasseva Christina Popova Maya Kicheva |
| author_facet | Antoaneta Mlachkova Zdravka Pashova-Tasseva Christina Popova Maya Kicheva |
| author_sort | Antoaneta Mlachkova |
| collection | DOAJ |
| description | Introduction: It`s well known that the periodontitis is а complex disease initiated by bacteria, but modified by environmental factors and the host response. As any other chronic disease, the periodontal disease is influenced by the individual predisposition of the patient to develop the specific symptoms. The increasing number of studies in the area of the genetic factors and mechanisms of the patient to develop the specific condition is leading to the need for certain polymоrphism’s to be studied in details for the Bulgarian population.
Aim: The recent study aims to identify the presence of SNP of IL-17F in the Bulgarian population.
Materials and methods: In the study, 40 patients with periodontitis stage II, III and IV and 10 healthy control subjects were taking part. The age of the subjects varied between 23 and 75 with an average value of 46 years. Clinical and radiographic methods to establish the basic periodontal parameters were used. Laboratory methods were performed by means of Real-Time PCR for determination of SNP of Interleukin 17F (IL-17F) (-7488C/T rs_763780). The statistic data was processed with PCA – IBM SPSS Statistics Version 21. From all of the patients, informed consent was taken.
Results: The recent study collected information about the dominating genotype when studying SNP of IL-17 F for patients with periodontitis. The presence of two genotypes was established – genotype TT (92%) and genotype CT (8%). We have established specific tendencies about the distribution of major parameter for diagnosis of periodontitis such as BoP and BL/Age in both groups. The individual host susceptibility can be used as a diagnostic parameter leading to the development of screening methods in order suspectable individuals to be found.
Conclusion: The study has contributed to clarifying the genetic characteristic of the tested subject. The results confirmed the data from different studies that aim to research the genetic polymorphism of IL-17F in relation to periodontitis. |
| first_indexed | 2024-12-22T13:26:47Z |
| format | Article |
| id | doaj.art-f1c594b72e5d48a9912102c38f8d1a1d |
| institution | Directory Open Access Journal |
| issn | 1312-773X |
| language | English |
| last_indexed | 2024-12-22T13:26:47Z |
| publishDate | 2021-04-01 |
| publisher | Peytchinski Publishing |
| record_format | Article |
| series | Journal of IMAB |
| spelling | doaj.art-f1c594b72e5d48a9912102c38f8d1a1d2022-12-21T18:24:18ZengPeytchinski PublishingJournal of IMAB1312-773X2021-04-012723692369910.5272/jimab.2021272.3692PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATIONAntoaneta Mlachkova0https://orcid.org/0000-0001-8381-8040Zdravka Pashova-Tasseva1https://orcid.org/0000-0002-2635-083XChristina Popova2https://orcid.org/0000-0003-3073-7647Maya Kicheva3https://orcid.org/0000-0003-3017-3554Department of Periodontology, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria.Department of Periodontology, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria.Department of Periodontology, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria.Department of Periodontology, Faculty of Dental Medicine, Medical University - Sofia, Bulgaria.Introduction: It`s well known that the periodontitis is а complex disease initiated by bacteria, but modified by environmental factors and the host response. As any other chronic disease, the periodontal disease is influenced by the individual predisposition of the patient to develop the specific symptoms. The increasing number of studies in the area of the genetic factors and mechanisms of the patient to develop the specific condition is leading to the need for certain polymоrphism’s to be studied in details for the Bulgarian population. Aim: The recent study aims to identify the presence of SNP of IL-17F in the Bulgarian population. Materials and methods: In the study, 40 patients with periodontitis stage II, III and IV and 10 healthy control subjects were taking part. The age of the subjects varied between 23 and 75 with an average value of 46 years. Clinical and radiographic methods to establish the basic periodontal parameters were used. Laboratory methods were performed by means of Real-Time PCR for determination of SNP of Interleukin 17F (IL-17F) (-7488C/T rs_763780). The statistic data was processed with PCA – IBM SPSS Statistics Version 21. From all of the patients, informed consent was taken. Results: The recent study collected information about the dominating genotype when studying SNP of IL-17 F for patients with periodontitis. The presence of two genotypes was established – genotype TT (92%) and genotype CT (8%). We have established specific tendencies about the distribution of major parameter for diagnosis of periodontitis such as BoP and BL/Age in both groups. The individual host susceptibility can be used as a diagnostic parameter leading to the development of screening methods in order suspectable individuals to be found. Conclusion: The study has contributed to clarifying the genetic characteristic of the tested subject. The results confirmed the data from different studies that aim to research the genetic polymorphism of IL-17F in relation to periodontitis.https://www.journal-imab-bg.org/issues-2021/issue2/2021vol27-issue2-3692-3699.pdfperiodontitisgene polymorphismsnpinterleukin-17f |
| spellingShingle | Antoaneta Mlachkova Zdravka Pashova-Tasseva Christina Popova Maya Kicheva PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATION Journal of IMAB periodontitis gene polymorphism snp interleukin-17f |
| title | PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATION |
| title_full | PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATION |
| title_fullStr | PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATION |
| title_full_unstemmed | PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATION |
| title_short | PRESENCE OF SNP OF INTERLEUKIN17F IN PATIENTS WITH PERIODONTITIS IN A BULGARIAN POPULATION |
| title_sort | presence of snp of interleukin17f in patients with periodontitis in a bulgarian population |
| topic | periodontitis gene polymorphism snp interleukin-17f |
| url | https://www.journal-imab-bg.org/issues-2021/issue2/2021vol27-issue2-3692-3699.pdf |
| work_keys_str_mv | AT antoanetamlachkova presenceofsnpofinterleukin17finpatientswithperiodontitisinabulgarianpopulation AT zdravkapashovatasseva presenceofsnpofinterleukin17finpatientswithperiodontitisinabulgarianpopulation AT christinapopova presenceofsnpofinterleukin17finpatientswithperiodontitisinabulgarianpopulation AT mayakicheva presenceofsnpofinterleukin17finpatientswithperiodontitisinabulgarianpopulation |