The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis
Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment application, which may red...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/11/8/1210 |
| _version_ | 1797524544127238144 |
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| author | Silke D. De Wolde Rick H. Hulskes Robert P. Weenink Markus W. Hollmann Robert A. Van Hulst |
| author_facet | Silke D. De Wolde Rick H. Hulskes Robert P. Weenink Markus W. Hollmann Robert A. Van Hulst |
| author_sort | Silke D. De Wolde |
| collection | DOAJ |
| description | Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment application, which may reduce complication rates and hospital stay. In this review, the effect of HBOT on oxidative stress, inflammation and angiogenesis is investigated to better understand the potential mechanisms underlying preconditioning for surgery using HBOT. A systematic search was conducted to retrieve studies measuring markers of oxidative stress, inflammation, or angiogenesis in humans. Analysis of the included studies showed that HBOT-induced oxidative stress reduces the concentrations of pro-inflammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines. Several articles only noted this surge after the first HBOT session or for a short duration after each session. The anti-inflammatory status following HBOT may be mediated by hyperoxia interfering with NF-κB and IκBα. Further research into the effect of HBOT on inflammation and angiogenesis is needed to determine the implications of these findings for clinical practice. |
| first_indexed | 2024-03-10T08:58:56Z |
| format | Article |
| id | doaj.art-f1c642d812b84af1ac50c44ce79527b8 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T08:58:56Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-f1c642d812b84af1ac50c44ce79527b82023-11-22T06:56:25ZengMDPI AGBiomolecules2218-273X2021-08-01118121010.3390/biom11081210The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and AngiogenesisSilke D. De Wolde0Rick H. Hulskes1Robert P. Weenink2Markus W. Hollmann3Robert A. Van Hulst4Department of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The NetherlandsDepartment of Anesthesiology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The NetherlandsHyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment application, which may reduce complication rates and hospital stay. In this review, the effect of HBOT on oxidative stress, inflammation and angiogenesis is investigated to better understand the potential mechanisms underlying preconditioning for surgery using HBOT. A systematic search was conducted to retrieve studies measuring markers of oxidative stress, inflammation, or angiogenesis in humans. Analysis of the included studies showed that HBOT-induced oxidative stress reduces the concentrations of pro-inflammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines. Several articles only noted this surge after the first HBOT session or for a short duration after each session. The anti-inflammatory status following HBOT may be mediated by hyperoxia interfering with NF-κB and IκBα. Further research into the effect of HBOT on inflammation and angiogenesis is needed to determine the implications of these findings for clinical practice.https://www.mdpi.com/2218-273X/11/8/1210hyperbaric oxygen therapyhyperbaric oxygenationoxidative stressinflammationangiogenesisneovascularization |
| spellingShingle | Silke D. De Wolde Rick H. Hulskes Robert P. Weenink Markus W. Hollmann Robert A. Van Hulst The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis Biomolecules hyperbaric oxygen therapy hyperbaric oxygenation oxidative stress inflammation angiogenesis neovascularization |
| title | The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis |
| title_full | The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis |
| title_fullStr | The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis |
| title_full_unstemmed | The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis |
| title_short | The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis |
| title_sort | effects of hyperbaric oxygenation on oxidative stress inflammation and angiogenesis |
| topic | hyperbaric oxygen therapy hyperbaric oxygenation oxidative stress inflammation angiogenesis neovascularization |
| url | https://www.mdpi.com/2218-273X/11/8/1210 |
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