Differentiation of stable kidney function versus progressive dysfunction in dogs
Abstract Background Circulating creatinine and symmetric dimethylarginine (SDMA) are biomarkers of kidney function that have been used variously to define stable vs progressive chronic kidney disease (CKD). Slope monitoring of inverse biomarker values (creatinine−1 or SDMA−1) has shown promise, but...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16885 |
| _version_ | 1797248112538943488 |
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| author | Larry D. Cowgill Gilad Segev Shelly Vaden Sheri Ross Cedric Dufayet Leah A. Cohn Mary Nabity Giosi Farace Donald Szlosek Zenhwa Ouyang Sarah Peterson Melissa Beall Murthy Yerramilli David Polzin |
| author_facet | Larry D. Cowgill Gilad Segev Shelly Vaden Sheri Ross Cedric Dufayet Leah A. Cohn Mary Nabity Giosi Farace Donald Szlosek Zenhwa Ouyang Sarah Peterson Melissa Beall Murthy Yerramilli David Polzin |
| author_sort | Larry D. Cowgill |
| collection | DOAJ |
| description | Abstract Background Circulating creatinine and symmetric dimethylarginine (SDMA) are biomarkers of kidney function that have been used variously to define stable vs progressive chronic kidney disease (CKD). Slope monitoring of inverse biomarker values (creatinine−1 or SDMA−1) has shown promise, but quantitative criteria to distinguish stable vs progressive CKD using this approach are lacking. Objective Assessment of creatinine−1 and SDMA−1 slope cutoffs to distinguish stable vs progressive CKD. Animals One hundred ten clinically healthy university staff‐owned dogs and 29 male colony dogs with progressive X‐linked hereditary nephropathy (XLHN). Methods Retrospective analysis combining 2 prospective observational studies, 1 tracking kidney function biomarkers in healthy dogs (HDs) to a maximum of 3 years, and 1 tracking kidney function biomarkers in male colony dogs with progressive XLHN to a maximum of 1 year. The minimum slope of creatinine−1 or SDMA−1 as measured using the IDEXX SDMA test from HD was assigned as the slope cutoff for stable kidney function. Results The stable vs progressive slope cutoff was −0.0119 week × dL/mg for creatinine−1 and −0.0007 week × dL/μg for SDMA−1. Conclusions and Clinical Importance In the studied CKD population, progressive dysfunction can be distinguished from stable kidney function by using the slope of creatinine−1 or SDMA−1. These criteria may serve to characterize CKD in other cohorts of dogs and to establish guidelines for degrees of progression rate in dogs with naturally occurring CKD. |
| first_indexed | 2024-03-09T00:19:52Z |
| format | Article |
| id | doaj.art-f1c6d9b6f2ef4c3897d241975b97ebca |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-24T20:09:25Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-f1c6d9b6f2ef4c3897d241975b97ebca2024-03-23T17:56:17ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762023-11-013762241225010.1111/jvim.16885Differentiation of stable kidney function versus progressive dysfunction in dogsLarry D. Cowgill0Gilad Segev1Shelly Vaden2Sheri Ross3Cedric Dufayet4Leah A. Cohn5Mary Nabity6Giosi Farace7Donald Szlosek8Zenhwa Ouyang9Sarah Peterson10Melissa Beall11Murthy Yerramilli12David Polzin13University of California‐Davis Davis California USAHebrew University Jerusalem IsraelNorth Carolina State University Raleigh North Carolina USAUniversity of Prince Edward Island Charlottetown Prince Edward Island CanadaUniversity of California Veterinary Medical Center‐San Diego San Diego California USAUniversity of Missouri Veterinary Health Center Columbia Missouri USATexas A&M University College Station Texas USAIDEXX Laboratories, Inc. Westbrook Maine USAIDEXX Laboratories, Inc. Westbrook Maine USAIDEXX Laboratories, Inc. Westbrook Maine USAIDEXX Laboratories, Inc. Westbrook Maine USAIDEXX Laboratories, Inc. Westbrook Maine USAIDEXX Laboratories, Inc. Westbrook Maine USAUniversity of Minnesota Minneapolis Minnesota USAAbstract Background Circulating creatinine and symmetric dimethylarginine (SDMA) are biomarkers of kidney function that have been used variously to define stable vs progressive chronic kidney disease (CKD). Slope monitoring of inverse biomarker values (creatinine−1 or SDMA−1) has shown promise, but quantitative criteria to distinguish stable vs progressive CKD using this approach are lacking. Objective Assessment of creatinine−1 and SDMA−1 slope cutoffs to distinguish stable vs progressive CKD. Animals One hundred ten clinically healthy university staff‐owned dogs and 29 male colony dogs with progressive X‐linked hereditary nephropathy (XLHN). Methods Retrospective analysis combining 2 prospective observational studies, 1 tracking kidney function biomarkers in healthy dogs (HDs) to a maximum of 3 years, and 1 tracking kidney function biomarkers in male colony dogs with progressive XLHN to a maximum of 1 year. The minimum slope of creatinine−1 or SDMA−1 as measured using the IDEXX SDMA test from HD was assigned as the slope cutoff for stable kidney function. Results The stable vs progressive slope cutoff was −0.0119 week × dL/mg for creatinine−1 and −0.0007 week × dL/μg for SDMA−1. Conclusions and Clinical Importance In the studied CKD population, progressive dysfunction can be distinguished from stable kidney function by using the slope of creatinine−1 or SDMA−1. These criteria may serve to characterize CKD in other cohorts of dogs and to establish guidelines for degrees of progression rate in dogs with naturally occurring CKD.https://doi.org/10.1111/jvim.16885biomarkercreatininedisease monitoringinverse slopesymmetric dimethylarginine |
| spellingShingle | Larry D. Cowgill Gilad Segev Shelly Vaden Sheri Ross Cedric Dufayet Leah A. Cohn Mary Nabity Giosi Farace Donald Szlosek Zenhwa Ouyang Sarah Peterson Melissa Beall Murthy Yerramilli David Polzin Differentiation of stable kidney function versus progressive dysfunction in dogs Journal of Veterinary Internal Medicine biomarker creatinine disease monitoring inverse slope symmetric dimethylarginine |
| title | Differentiation of stable kidney function versus progressive dysfunction in dogs |
| title_full | Differentiation of stable kidney function versus progressive dysfunction in dogs |
| title_fullStr | Differentiation of stable kidney function versus progressive dysfunction in dogs |
| title_full_unstemmed | Differentiation of stable kidney function versus progressive dysfunction in dogs |
| title_short | Differentiation of stable kidney function versus progressive dysfunction in dogs |
| title_sort | differentiation of stable kidney function versus progressive dysfunction in dogs |
| topic | biomarker creatinine disease monitoring inverse slope symmetric dimethylarginine |
| url | https://doi.org/10.1111/jvim.16885 |
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