Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings
This case reports rare findings on computed tomography of a manifestation of malignant lymphoma, in which diffuse lung shadows appeared as miliary nodules distributed throughout the lungs bilaterally. The patient had a history of surgical treatment of rectal cancer and had received chemotherapy for...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Respiratory Medicine Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007120304536 |
| _version_ | 1831741949937188864 |
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| author | Kyoko Yagyu Masaaki Kobayashi Takahiro Ueda Riki Uenishi Yuko Nakatsuji Haruhiko Matsushita |
| author_facet | Kyoko Yagyu Masaaki Kobayashi Takahiro Ueda Riki Uenishi Yuko Nakatsuji Haruhiko Matsushita |
| author_sort | Kyoko Yagyu |
| collection | DOAJ |
| description | This case reports rare findings on computed tomography of a manifestation of malignant lymphoma, in which diffuse lung shadows appeared as miliary nodules distributed throughout the lungs bilaterally. The patient had a history of surgical treatment of rectal cancer and had received chemotherapy for suspicious liver metastasis. At her current presentation for evaluation suspected miliary tuberculosis on chest radiography, subsequent liver biopsy revealed a mass infiltration of atypical lymphocytes, which was diagnosed as follicular lymphoma. The miliary tuberculosis was suspected more than neoplastic lesions, such as metastatic rectal cancer or malignant lymphoma. Despite repeated bacteriologic tests of various samples, including sputum, urine, bronchial secretion, peripheral blood, bone marrow aspiration, and gastric lavage, all results were negative for mycobacterium tuberculosis. Finally, multiple, small, mass lesions of lymphocytes were demonstrated in the lung obtained from video-assisted thoracic surgery, and a diagnosis of follicular lymphoma was given. The final interpretations of liver mass and military lung lesions were tumor involvement by the follicular lymphoma. This radiologic findings of multiple miliary opacities throughout the whole lungs confused definite diagnosis because these images were remarkably similar with miliary tuberculous. This case reminds us to consider a wide variety of differential diagnoses even we assumed to be familiar with radiographic imaging at first glance. |
| first_indexed | 2024-12-21T14:25:40Z |
| format | Article |
| id | doaj.art-f1c71cdc4b1c4228b19927abd4b05ab8 |
| institution | Directory Open Access Journal |
| issn | 2213-0071 |
| language | English |
| last_indexed | 2024-12-21T14:25:40Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj.art-f1c71cdc4b1c4228b19927abd4b05ab82022-12-21T19:00:39ZengElsevierRespiratory Medicine Case Reports2213-00712020-01-0131101239Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findingsKyoko Yagyu0Masaaki Kobayashi1Takahiro Ueda2Riki Uenishi3Yuko Nakatsuji4Haruhiko Matsushita5Corresponding author. Department of Respiratory Medicine, Izumi City General Hospital, 4-5-1Wake-Cho, Izumi-city, Osaka, 594-0073, Japan.; Department of Respiratory Medicine, Izumi City General Hospital, JapanDepartment of Respiratory Medicine, Izumi City General Hospital, JapanDepartment of Respiratory Medicine, Izumi City General Hospital, JapanDepartment of Respiratory Medicine, Izumi City General Hospital, JapanDepartment of Respiratory Medicine, Izumi City General Hospital, JapanDepartment of Respiratory Medicine, Izumi City General Hospital, JapanThis case reports rare findings on computed tomography of a manifestation of malignant lymphoma, in which diffuse lung shadows appeared as miliary nodules distributed throughout the lungs bilaterally. The patient had a history of surgical treatment of rectal cancer and had received chemotherapy for suspicious liver metastasis. At her current presentation for evaluation suspected miliary tuberculosis on chest radiography, subsequent liver biopsy revealed a mass infiltration of atypical lymphocytes, which was diagnosed as follicular lymphoma. The miliary tuberculosis was suspected more than neoplastic lesions, such as metastatic rectal cancer or malignant lymphoma. Despite repeated bacteriologic tests of various samples, including sputum, urine, bronchial secretion, peripheral blood, bone marrow aspiration, and gastric lavage, all results were negative for mycobacterium tuberculosis. Finally, multiple, small, mass lesions of lymphocytes were demonstrated in the lung obtained from video-assisted thoracic surgery, and a diagnosis of follicular lymphoma was given. The final interpretations of liver mass and military lung lesions were tumor involvement by the follicular lymphoma. This radiologic findings of multiple miliary opacities throughout the whole lungs confused definite diagnosis because these images were remarkably similar with miliary tuberculous. This case reminds us to consider a wide variety of differential diagnoses even we assumed to be familiar with radiographic imaging at first glance.http://www.sciencedirect.com/science/article/pii/S2213007120304536Diagnostic imagingFollicular lymphomaPulmonary secondary lymphomaMiliary opacity |
| spellingShingle | Kyoko Yagyu Masaaki Kobayashi Takahiro Ueda Riki Uenishi Yuko Nakatsuji Haruhiko Matsushita Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings Respiratory Medicine Case Reports Diagnostic imaging Follicular lymphoma Pulmonary secondary lymphoma Miliary opacity |
| title | Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings |
| title_full | Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings |
| title_fullStr | Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings |
| title_full_unstemmed | Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings |
| title_short | Malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings |
| title_sort | malignant lymphoma mimics miliary tuberculosis by diffuse micronodular radiographic findings |
| topic | Diagnostic imaging Follicular lymphoma Pulmonary secondary lymphoma Miliary opacity |
| url | http://www.sciencedirect.com/science/article/pii/S2213007120304536 |
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