Calotropin and corotoxigenin 3-O-glucopyranoside from the desert milkweed Asclepias subulata inhibit the Na+/K+-ATPase activity

Calotropin and corotoxigenin 3-O-glucopyranoside from the desert milkweed Asclepias subulata inhibit the Na+/K+-ATPase activity

Na+/K+-ATPase is an essential transmembrane enzyme found in all mammalian cells with critical functions for cell ion homeostasis. The inhibition of this enzyme by several cardiotonic steroids (CTS) has been associated with the cytotoxic effect on cancer cell lines of phytochemicals such as ouabain a...

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Bibliographic Details
Main Authors: Salvador E. Meneses-Sagrero, Luisa A. Rascón-Valenzuela, Juan C. García-Ramos, Wagner Vilegas, Aldo A. Arvizu-Flores, Rogerio R. Sotelo-Mundo, Ramon E. Robles-Zepeda
Format: Article
Language:English
Published: PeerJ Inc. 2022-06-01
Series:PeerJ
Subjects:
Cardenolides
ATPase activity
Asclepias subulata
Uncompetitive inhibition
Online Access:https://peerj.com/articles/13524.pdf

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