IFNγ-INDUCED KINURENINE PRODUCTION AND INDOLAMINE 2,3-DIOXYGENASE GENE EXPRESSION IN PSORIASIS

IFNγ-INDUCED KINURENINE PRODUCTION AND INDOLAMINE 2,3-DIOXYGENASE GENE EXPRESSION IN PSORIASIS

Abstract. An alternative pathway of L-tryptophan biotransformation is provided by the indolamine 2,3-dioxygenase (INDO), and it results into synthesis of kynurenine and other «distal» metabolites, playing a pivotal role in immunoregulation and down-regulation of immune inflammation. PBMCs from healt...

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Bibliographic Details
Main Authors: D. A. Kaut, R. S. Yamidanov, S. V. Sadovnikov, O. M. Kapuler, V. A. Vakhitov, S. V. Sibiryak
Format: Article
Language:Russian
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2014-07-01
Series:Медицинская иммунология
Subjects:
ifnγ
kinurenine
indolamine 2,3-dioxygenase
psoriasis
Online Access:https://www.mimmun.ru/mimmun/article/view/277

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