Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis
Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specia...
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Plant Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpls.2022.866282/full |
| _version_ | 1818489772325208064 |
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| author | Tianlin Pei Tianlin Pei Mengxiao Yan Yanbo Huang Yukun Wei Cathie Martin Qing Zhao Qing Zhao |
| author_facet | Tianlin Pei Tianlin Pei Mengxiao Yan Yanbo Huang Yukun Wei Cathie Martin Qing Zhao Qing Zhao |
| author_sort | Tianlin Pei |
| collection | DOAJ |
| description | Scutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specialized flavones such as baicalein, wogonin, and their glycosides which lack a 4′-hydroxyl group on the B ring (4′-deoxyflavones), with anti-tumor, antioxidant, and antiviral activities. Baicalein has recently been reported to inhibit the replication of the COVID-19 virus. These 4′-deoxyflavones are found only in the order Lamiales and were discovered in the genus Scutellaria, suggesting that a new metabolic pathway synthesizing 4′-deoxyflavones evolved recently in this genus. In this review, we focus on the class of 4′-deoxyflavones in S. baicalensis and their pharmacological properties. We also describe the apparent evolutionary route taken by the genes encoding enzymes involved in the novel, root-specific, biosynthetic pathway for baicalein and wogonin, which provides insights into the evolution of specific flavone biosynthetic pathways in the mint family. |
| first_indexed | 2024-12-10T17:07:57Z |
| format | Article |
| id | doaj.art-f1c88a03d5eb4cc381c41c9caefd02f7 |
| institution | Directory Open Access Journal |
| issn | 1664-462X |
| language | English |
| last_indexed | 2024-12-10T17:07:57Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Plant Science |
| spelling | doaj.art-f1c88a03d5eb4cc381c41c9caefd02f72022-12-22T01:40:24ZengFrontiers Media S.A.Frontiers in Plant Science1664-462X2022-03-011310.3389/fpls.2022.866282866282Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensisTianlin Pei0Tianlin Pei1Mengxiao Yan2Yanbo Huang3Yukun Wei4Cathie Martin5Qing Zhao6Qing Zhao7Shanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Botanical Garden, Shanghai, ChinaNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, ChinaShanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Botanical Garden, Shanghai, ChinaShanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Botanical Garden, Shanghai, ChinaShanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Botanical Garden, Shanghai, ChinaJohn Innes Centre, Norwich, United KingdomShanghai Key Laboratory of Plant Functional Genomics and Resources, Shanghai Chenshan Botanical Garden, Shanghai, ChinaNational Key Laboratory of Plant Molecular Genetics, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, ChinaScutellaria baicalensis, is one of the most traditional medicinal plants in the Lamiaceae family, and has been widely used to treat liver and lung complaints and as a complementary cancer treatment in traditional Chinese medicine. The preparation from its roots, called “Huang Qin,” is rich in specialized flavones such as baicalein, wogonin, and their glycosides which lack a 4′-hydroxyl group on the B ring (4′-deoxyflavones), with anti-tumor, antioxidant, and antiviral activities. Baicalein has recently been reported to inhibit the replication of the COVID-19 virus. These 4′-deoxyflavones are found only in the order Lamiales and were discovered in the genus Scutellaria, suggesting that a new metabolic pathway synthesizing 4′-deoxyflavones evolved recently in this genus. In this review, we focus on the class of 4′-deoxyflavones in S. baicalensis and their pharmacological properties. We also describe the apparent evolutionary route taken by the genes encoding enzymes involved in the novel, root-specific, biosynthetic pathway for baicalein and wogonin, which provides insights into the evolution of specific flavone biosynthetic pathways in the mint family.https://www.frontiersin.org/articles/10.3389/fpls.2022.866282/fullScutellaria baicalensis4′-deoxyflavonesflavonoidsbiosynthetic pathwaysevolutionary mechanisms |
| spellingShingle | Tianlin Pei Tianlin Pei Mengxiao Yan Yanbo Huang Yukun Wei Cathie Martin Qing Zhao Qing Zhao Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis Frontiers in Plant Science Scutellaria baicalensis 4′-deoxyflavones flavonoids biosynthetic pathways evolutionary mechanisms |
| title | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
| title_full | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
| title_fullStr | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
| title_full_unstemmed | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
| title_short | Specific Flavonoids and Their Biosynthetic Pathway in Scutellaria baicalensis |
| title_sort | specific flavonoids and their biosynthetic pathway in scutellaria baicalensis |
| topic | Scutellaria baicalensis 4′-deoxyflavones flavonoids biosynthetic pathways evolutionary mechanisms |
| url | https://www.frontiersin.org/articles/10.3389/fpls.2022.866282/full |
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