Understanding the Influenza A H1N1 2009 Pandemic
A new strain of Influenza A virus, with quadruple segment translocation in its RNA, caused an outbreak of human infection in April 2009 in USA and Mexico. It was classified as Influenza A H1N1 2009. The genetic material originates from three different species: human, avian and swine. By June 2009, t...
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| Format: | Article |
| Language: | English |
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Sultan Qaboos University
2010-08-01
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| Series: | Sultan Qaboos University Medical Journal |
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| Online Access: | https://journals.squ.edu.om/index.php/squmj/article/view/1492 |
| _version_ | 1823998752444121088 |
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| author | Zakariya Al-Muharrmi |
| author_facet | Zakariya Al-Muharrmi |
| author_sort | Zakariya Al-Muharrmi |
| collection | DOAJ |
| description | A new strain of Influenza A virus, with quadruple segment translocation in its RNA, caused an outbreak of human infection in April 2009 in USA and Mexico. It was classified as Influenza A H1N1 2009. The genetic material originates from three different species: human, avian and swine. By June 2009, the World Health Organization (WHO) had classified this strain as a pandemic virus, making it the first pandemic in 40 years. Influenza A H1N1 2009 is transmitted by respiratory droplets; the transmissibility of this strain is higher than other influenza strains which made infection control difficult. The majority of cases of H1N1 2009 were mild and self limiting, but some people developed complications and others died. Most laboratory tests are insensitive except the polymerase chain reaction (PCR) which is expensive and labour intensive. The Influenza A H1N1 2009 virus is sensitive to neuraminidase inhibitors (oseltamivir and zanamivir), but some isolates resistant to oseltamivir have been reported. A vaccine against the new pandemic strain was available by mid-September 2009 with very good immunogenicity and safety profile. Surveillance is very important at all stages of any pandemic to detect and monitor the trend of viral infections and to prevent the occurrence of future pandemics. The aim of this review is to understand pandemic influenza viruses, and what strategies can be used for surveillance, mitigation and control. |
| first_indexed | 2024-12-18T17:34:12Z |
| format | Article |
| id | doaj.art-f1c8ba023b2346b8af8c7b830c6fab09 |
| institution | Directory Open Access Journal |
| issn | 2075-051X 2075-0528 |
| language | English |
| last_indexed | 2024-12-18T17:34:12Z |
| publishDate | 2010-08-01 |
| publisher | Sultan Qaboos University |
| record_format | Article |
| series | Sultan Qaboos University Medical Journal |
| spelling | doaj.art-f1c8ba023b2346b8af8c7b830c6fab092022-12-21T20:59:24ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal2075-051X2075-05282010-08-011021871951419Understanding the Influenza A H1N1 2009 PandemicZakariya Al-Muharrmi0Department of Microbiology & Immunology, Sultan Qaboos University Hospital, Muscat, Sultanate of OmanA new strain of Influenza A virus, with quadruple segment translocation in its RNA, caused an outbreak of human infection in April 2009 in USA and Mexico. It was classified as Influenza A H1N1 2009. The genetic material originates from three different species: human, avian and swine. By June 2009, the World Health Organization (WHO) had classified this strain as a pandemic virus, making it the first pandemic in 40 years. Influenza A H1N1 2009 is transmitted by respiratory droplets; the transmissibility of this strain is higher than other influenza strains which made infection control difficult. The majority of cases of H1N1 2009 were mild and self limiting, but some people developed complications and others died. Most laboratory tests are insensitive except the polymerase chain reaction (PCR) which is expensive and labour intensive. The Influenza A H1N1 2009 virus is sensitive to neuraminidase inhibitors (oseltamivir and zanamivir), but some isolates resistant to oseltamivir have been reported. A vaccine against the new pandemic strain was available by mid-September 2009 with very good immunogenicity and safety profile. Surveillance is very important at all stages of any pandemic to detect and monitor the trend of viral infections and to prevent the occurrence of future pandemics. The aim of this review is to understand pandemic influenza viruses, and what strategies can be used for surveillance, mitigation and control.https://journals.squ.edu.om/index.php/squmj/article/view/1492influenzapandemicpolymerase chain reactionvaccinesurveillance. |
| spellingShingle | Zakariya Al-Muharrmi Understanding the Influenza A H1N1 2009 Pandemic Sultan Qaboos University Medical Journal influenza pandemic polymerase chain reaction vaccine surveillance. |
| title | Understanding the Influenza A H1N1 2009 Pandemic |
| title_full | Understanding the Influenza A H1N1 2009 Pandemic |
| title_fullStr | Understanding the Influenza A H1N1 2009 Pandemic |
| title_full_unstemmed | Understanding the Influenza A H1N1 2009 Pandemic |
| title_short | Understanding the Influenza A H1N1 2009 Pandemic |
| title_sort | understanding the influenza a h1n1 2009 pandemic |
| topic | influenza pandemic polymerase chain reaction vaccine surveillance. |
| url | https://journals.squ.edu.om/index.php/squmj/article/view/1492 |
| work_keys_str_mv | AT zakariyaalmuharrmi understandingtheinfluenzaah1n12009pandemic |