Breastmilk influences development and composition of the oral microbiome
Background Human microbiomes assemble in an ordered, reproducible manner yet there is limited information about early colonisation and development of bacterial communities that constitute the oral microbiome.Aim The aim of this study was to determine the effect of exposure to breastmilk on assembly...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Journal of Oral Microbiology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/20002297.2022.2096287 |
| _version_ | 1818113460117962752 |
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| author | Catherine A. Butler Geoffrey G. Adams Jordan Blum Samantha J. Byrne Lauren Carpenter Mark G. Gussy Hanny Calache Deanne V. Catmull Eric C. Reynolds Stuart G. Dashper |
| author_facet | Catherine A. Butler Geoffrey G. Adams Jordan Blum Samantha J. Byrne Lauren Carpenter Mark G. Gussy Hanny Calache Deanne V. Catmull Eric C. Reynolds Stuart G. Dashper |
| author_sort | Catherine A. Butler |
| collection | DOAJ |
| description | Background Human microbiomes assemble in an ordered, reproducible manner yet there is limited information about early colonisation and development of bacterial communities that constitute the oral microbiome.Aim The aim of this study was to determine the effect of exposure to breastmilk on assembly of the infant oral microbiome during the first 20 months of life.Methods The oral microbiomes of 39 infants, 13 who were never breastfed and 26 who were breastfed for more than 10 months, from the longitudinal VicGeneration birth cohort study, were determined at four ages. In total, 519 bacterial taxa were identified and quantified in saliva by sequencing the V4 region of the bacterial 16S rRNA genes.Results There were significant differences in the development of the oral microbiomes of never breastfed and breastfed infants. Bacterial diversity was significantly higher in never breastfed infants at 2 months, due largely to an increased abundance of Veillonella and species from the Bacteroidetes phylum compared with breastfed infants.Conclusion These differences likely reflect breastmilk playing a prebiotic role in selection of early-colonising, health-associated oral bacteria, such as the Streptococcus mitis group. The microbiomes of both groups became more heterogenous following the introduction of solid foods. |
| first_indexed | 2024-12-11T03:35:11Z |
| format | Article |
| id | doaj.art-f1cd07859d4041d98d5ce554d8014058 |
| institution | Directory Open Access Journal |
| issn | 2000-2297 |
| language | English |
| last_indexed | 2024-12-11T03:35:11Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Oral Microbiology |
| spelling | doaj.art-f1cd07859d4041d98d5ce554d80140582022-12-22T01:22:17ZengTaylor & Francis GroupJournal of Oral Microbiology2000-22972022-12-0114110.1080/20002297.2022.2096287Breastmilk influences development and composition of the oral microbiomeCatherine A. Butler0Geoffrey G. Adams1Jordan Blum2Samantha J. Byrne3Lauren Carpenter4Mark G. Gussy5Hanny Calache6Deanne V. Catmull7Eric C. Reynolds8Stuart G. Dashper9Centre for Oral Health Research, Melbourne Dental School, University of Melbourne, Carlton, Vic, AustraliaCentre for Oral Health Research, Melbourne Dental School, University of Melbourne, Carlton, Vic, AustraliaCentre for Oral Health Research, Melbourne Dental School, University of Melbourne, Carlton, Vic, AustraliaCentre for Oral Health Research, Melbourne Dental School, University of Melbourne, Carlton, Vic, AustraliaChild and Community Wellbeing Unit, Melbourne School of Population & Global Health, University of Melbourne, Carlton, Vic, AustraliaLincoln International Institute for Rural Health, College of Social Science, University of Lincoln, Lincoln, UKSchool of Health and Social Development, Deakin University, Burwood, Vic, AustraliaCentre for Oral Health Research, Melbourne Dental School, University of Melbourne, Carlton, Vic, AustraliaCentre for Oral Health Research, Melbourne Dental School, University of Melbourne, Carlton, Vic, AustraliaCentre for Oral Health Research, Melbourne Dental School, University of Melbourne, Carlton, Vic, AustraliaBackground Human microbiomes assemble in an ordered, reproducible manner yet there is limited information about early colonisation and development of bacterial communities that constitute the oral microbiome.Aim The aim of this study was to determine the effect of exposure to breastmilk on assembly of the infant oral microbiome during the first 20 months of life.Methods The oral microbiomes of 39 infants, 13 who were never breastfed and 26 who were breastfed for more than 10 months, from the longitudinal VicGeneration birth cohort study, were determined at four ages. In total, 519 bacterial taxa were identified and quantified in saliva by sequencing the V4 region of the bacterial 16S rRNA genes.Results There were significant differences in the development of the oral microbiomes of never breastfed and breastfed infants. Bacterial diversity was significantly higher in never breastfed infants at 2 months, due largely to an increased abundance of Veillonella and species from the Bacteroidetes phylum compared with breastfed infants.Conclusion These differences likely reflect breastmilk playing a prebiotic role in selection of early-colonising, health-associated oral bacteria, such as the Streptococcus mitis group. The microbiomes of both groups became more heterogenous following the introduction of solid foods.https://www.tandfonline.com/doi/10.1080/20002297.2022.2096287Oral cavitybreastfeedingtemporal developmentearly childhoodinfant |
| spellingShingle | Catherine A. Butler Geoffrey G. Adams Jordan Blum Samantha J. Byrne Lauren Carpenter Mark G. Gussy Hanny Calache Deanne V. Catmull Eric C. Reynolds Stuart G. Dashper Breastmilk influences development and composition of the oral microbiome Journal of Oral Microbiology Oral cavity breastfeeding temporal development early childhood infant |
| title | Breastmilk influences development and composition of the oral microbiome |
| title_full | Breastmilk influences development and composition of the oral microbiome |
| title_fullStr | Breastmilk influences development and composition of the oral microbiome |
| title_full_unstemmed | Breastmilk influences development and composition of the oral microbiome |
| title_short | Breastmilk influences development and composition of the oral microbiome |
| title_sort | breastmilk influences development and composition of the oral microbiome |
| topic | Oral cavity breastfeeding temporal development early childhood infant |
| url | https://www.tandfonline.com/doi/10.1080/20002297.2022.2096287 |
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