Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance
We have reviewed the development and current status of therapies based on exposure to non-ionizing radiation (with a photon energy less than 10 eV) aimed at suppressing the venous neointimal hyperplasia, and consequentially at avoiding stenosis in arteriovenous grafts. Due to the drawbacks associate...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-02-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1356671/full |
| _version_ | 1827357860300849152 |
|---|---|
| author | Eliza Russu Eliza Russu Emil-Marian Arbanasi Emil-Marian Arbanasi Emil-Marian Arbanasi Emil-Marian Arbanasi Traian V. Chirila Traian V. Chirila Traian V. Chirila Traian V. Chirila Traian V. Chirila Adrian V. Muresan Adrian V. Muresan |
| author_facet | Eliza Russu Eliza Russu Emil-Marian Arbanasi Emil-Marian Arbanasi Emil-Marian Arbanasi Emil-Marian Arbanasi Traian V. Chirila Traian V. Chirila Traian V. Chirila Traian V. Chirila Traian V. Chirila Adrian V. Muresan Adrian V. Muresan |
| author_sort | Eliza Russu |
| collection | DOAJ |
| description | We have reviewed the development and current status of therapies based on exposure to non-ionizing radiation (with a photon energy less than 10 eV) aimed at suppressing the venous neointimal hyperplasia, and consequentially at avoiding stenosis in arteriovenous grafts. Due to the drawbacks associated with the medical use of ionizing radiation, prominently the radiation-induced cardiovascular disease, the availability of procedures using non-ionizing radiation is becoming a noteworthy objective for the current research. Further, the focus of the review was the use of such procedures for improving the vascular access function and assuring the clinical success of arteriovenous fistulae in hemodialysis patients. Following a brief discussion of the physical principles underlying radiotherapy, the current methods based on non-ionizing radiation, either in use or under development, were described in detail. There are currently five such techniques, including photodynamic therapy (PDT), far-infrared therapy, photochemical tissue passivation (PTP), Alucent vascular scaffolding, and adventitial photocrosslinking. The last three are contingent on the mechanical stiffening achievable by the exogenous photochemical crosslinking of tissular collagen, a process that leads to the decrease of venous compliance. As there are conflicting opinions on the role of compliance mismatch between arterial and venous conduits in a graft, this aspect was also considered in our review. |
| first_indexed | 2024-03-08T05:54:08Z |
| format | Article |
| id | doaj.art-f1cdf005e4b04ac4bcf6fbc1d6a6c1d4 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T05:54:08Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-f1cdf005e4b04ac4bcf6fbc1d6a6c1d42024-02-05T04:58:06ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-02-011110.3389/fcvm.2024.13566711356671Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular complianceEliza Russu0Eliza Russu1Emil-Marian Arbanasi2Emil-Marian Arbanasi3Emil-Marian Arbanasi4Emil-Marian Arbanasi5Traian V. Chirila6Traian V. Chirila7Traian V. Chirila8Traian V. Chirila9Traian V. Chirila10Adrian V. Muresan11Adrian V. Muresan12Clinic of Vascular Surgery, Mures County Emergency Hospital, Targu Mures, RomaniaDepartment of Vascular Surgery, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, RomaniaClinic of Vascular Surgery, Mures County Emergency Hospital, Targu Mures, RomaniaDepartment of Vascular Surgery, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, RomaniaDoctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, RomaniaCentre for Advanced Medical and Pharmaceutical Research (CCAMF), George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, RomaniaCentre for Advanced Medical and Pharmaceutical Research (CCAMF), George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, RomaniaQueensland Eye Institute, Woolloongabba, QLD, AustraliaFaculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, RomaniaSchool of Chemistry and Physics, Queensland University of Technology, Brisbane, QLD, AustraliaAustralian Institute of Bioengineering and Nanotechnology (AIBN), University of Queensland, St Lucia, QLD, AustraliaClinic of Vascular Surgery, Mures County Emergency Hospital, Targu Mures, RomaniaDepartment of Vascular Surgery, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, RomaniaWe have reviewed the development and current status of therapies based on exposure to non-ionizing radiation (with a photon energy less than 10 eV) aimed at suppressing the venous neointimal hyperplasia, and consequentially at avoiding stenosis in arteriovenous grafts. Due to the drawbacks associated with the medical use of ionizing radiation, prominently the radiation-induced cardiovascular disease, the availability of procedures using non-ionizing radiation is becoming a noteworthy objective for the current research. Further, the focus of the review was the use of such procedures for improving the vascular access function and assuring the clinical success of arteriovenous fistulae in hemodialysis patients. Following a brief discussion of the physical principles underlying radiotherapy, the current methods based on non-ionizing radiation, either in use or under development, were described in detail. There are currently five such techniques, including photodynamic therapy (PDT), far-infrared therapy, photochemical tissue passivation (PTP), Alucent vascular scaffolding, and adventitial photocrosslinking. The last three are contingent on the mechanical stiffening achievable by the exogenous photochemical crosslinking of tissular collagen, a process that leads to the decrease of venous compliance. As there are conflicting opinions on the role of compliance mismatch between arterial and venous conduits in a graft, this aspect was also considered in our review.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1356671/fullvenous graftsneointimal hyperplasiaarteriovenous fistulanon-ionizing radiotherapiescollagen crosslinkingvascular compliance |
| spellingShingle | Eliza Russu Eliza Russu Emil-Marian Arbanasi Emil-Marian Arbanasi Emil-Marian Arbanasi Emil-Marian Arbanasi Traian V. Chirila Traian V. Chirila Traian V. Chirila Traian V. Chirila Traian V. Chirila Adrian V. Muresan Adrian V. Muresan Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance Frontiers in Cardiovascular Medicine venous grafts neointimal hyperplasia arteriovenous fistula non-ionizing radiotherapies collagen crosslinking vascular compliance |
| title | Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance |
| title_full | Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance |
| title_fullStr | Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance |
| title_full_unstemmed | Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance |
| title_short | Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: the relevance for stenosed arteriovenous fistula, and the role of vascular compliance |
| title_sort | therapeutic strategies based on non ionizing radiation to prevent venous neointimal hyperplasia the relevance for stenosed arteriovenous fistula and the role of vascular compliance |
| topic | venous grafts neointimal hyperplasia arteriovenous fistula non-ionizing radiotherapies collagen crosslinking vascular compliance |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1356671/full |
| work_keys_str_mv | AT elizarussu therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT elizarussu therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT emilmarianarbanasi therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT emilmarianarbanasi therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT emilmarianarbanasi therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT emilmarianarbanasi therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT traianvchirila therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT traianvchirila therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT traianvchirila therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT traianvchirila therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT traianvchirila therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT adrianvmuresan therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance AT adrianvmuresan therapeuticstrategiesbasedonnonionizingradiationtopreventvenousneointimalhyperplasiatherelevanceforstenosedarteriovenousfistulaandtheroleofvascularcompliance |